Protein: O95166

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O95166 (Uniprot) GBRAP_HUMAN GABARAP Gamma-aminobutyric acid receptor-associated protein human No
Uniprot: Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 404 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
404 GO:0044267 cellular protein metabolic process
404 GO:0007165 signal transduction
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
404 GO:0005829 cytosol
404 GO:0012505 endomembrane system
404 GO:0031982 vesicle
467 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000045 autophagosome assembly IBA
GO:0000226 microtubule cytoskeleton organization IEA
GO:0000422 autophagy of mitochondrion IBA
GO:0006605 protein targeting TAS
GO:0006995 cellular response to nitrogen starvation IBA
GO:0007268 chemical synaptic transmission TAS
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors IDA
GO:0016236 macroautophagy TAS
GO:0097352 autophagosome maturation TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000139 Golgi membrane IEA
GO:0000421 autophagosome membrane TAS
GO:0005764 lysosome IEA
GO:0005776 autophagosome IDA
GO:0005790 smooth endoplasmic reticulum IEA
GO:0005829 cytosol TAS
GO:0005874 microtubule IEA
GO:0005875 microtubule associated complex IEA
GO:0005886 plasma membrane IEA
GO:0005930 axoneme ISS
GO:0015629 actin cytoskeleton IEA
GO:0031410 cytoplasmic vesicle IEA
GO:0044297 cell body IEA
GO:0048471 perinuclear region of cytoplasm IEA
GO:0097225 sperm midpiece IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9892355 GABA(A)-receptor-associated protein links GABA(A) receptors and the cytoskeleton.
10931946 Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
11096062 The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
11146101 Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation.
11729197 The X-ray crystal structure and putative ligand-derived peptide binding properties of gamma-aminobutyric acid receptor type A receptor-associated protein.
11825910 Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.
11875056 Solution structure of human GABA(A) receptor-associated protein GABARAP: implications for biological function and its regulation.
11885988 1H, 13C and '5N resonance assignments of GABARAP, GABAA receptor associated protein.
12507496 GATE-16 and GABARAP are authentic modifiers mediated by Apg7 and Apg3.
15169837 LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation.
15977068 GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47).
17580304 p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
18638487 Ligand binding mode of GABAA receptor-associated protein.
19056683 The TP53INP2 protein is required for autophagy in mammalian cells.
19154346 Structural framework of the GABARAP-calreticulin interface -- implications for substrate binding to endoplasmic reticulum chaperones.
20562859 Network organization of the human autophagy system.
21269460 Initial characterization of the human central proteome.
21383079 OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
22354992 Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
22421968 TP53INP1, a tumor suppressor, interacts with LC3 and ATG8-family proteins through the LC3-interacting region (LIR) and promotes autophagy-dependent cell death.
22470510 DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
22948227 MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
23043107 ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs.
24089205 Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
24668264 Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
25127057 TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition.
26347139 TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity.
No results found.
Domain Name Domain ID Source
Atg8-like IPR004241 InterPro
Ubiquitin-like_domsf IPR029071 InterPro
Atg8 PF02991 Pfam
PTHR10969 PTHR10969 PANTHER
SSF54236 SSF54236 SUPFAM
GABARAP cd01611 CDD