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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P04278
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P04278 (Uniprot)
SHBG_HUMAN
SHBG
Sex hormone-binding globulin
human
No
Protein Function
Uniprot:
Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasm
a concentration.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0034641
cellular nitrogen compound metabolic process
180
GO:0007165
signal transduction
831
4.22e-144
6.90e-18
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 28 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
20
GO:0019538
protein metabolic process
20
GO:0007165
signal transduction
96
GO:0016070
RNA metabolic process
96
GO:0010467
gene expression
180
GO:0044271
cellular nitrogen compound biosynthetic process
180
GO:0070887
cellular response to chemical stimulus
180
GO:0006139
nucleobase-containing compound metabolic process
180
GO:0031325
positive regulation of cellular metabolic process
180
GO:0010604
positive regulation of macromolecule metabolic process
180
GO:2000112
regulation of cellular macromolecule biosynthetic process
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Cellular Components
Showing 1 to 10 of 19 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
18
GO:0005829
cytosol
18
GO:0070062
extracellular exosome
20
GO:0005886
plasma membrane
96
GO:0005654
nucleoplasm
180
GO:0005829
cytosol
180
GO:0070013
intracellular organelle lumen
180
GO:0044428
nuclear part
238
GO:0005829
cytosol
238
GO:0005634
nucleus
240
GO:0005615
extracellular space
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Protein GO Annotations
Biological Processes
No results found.
Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005576
extracellular region
NAS
GO:0070062
extracellular exosome
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 53 entries
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Interactor
Also a MoonDB EMF protein
A2MG_HUMAN
Yes:
P01023 (MoonDB)
ABC3C_HUMAN
No
ACPH_HUMAN
No
ACTA_HUMAN
No
ACTB_HUMAN
No
ACTH_HUMAN
No
ALDR_HUMAN
No
AP1B1_HUMAN
No
AP2A1_HUMAN
No
APOD_HUMAN
No
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Publications Associated
Showing 1 to 10 of 17 entries
Search:
PMID
Article Title
1400872
Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain.
2587256
Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.
2608061
The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.
2956125
Characterization of a cDNA coding for sex steroid-binding protein of human plasma.
2956126
A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.
3542030
Amino acid sequence of the sex steroid binding protein of human blood plasma.
3569533
The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain.
3702459
Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits.
7714097
Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects.
10391209
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 7 of 7 entries
Search:
Domain Name
Domain ID
Source
BOHUS
S09606
PIR
ConA-like_dom_sf
IPR013320
InterPro
LAM_G_DOMAIN
PS50025
PROSITE
LamG
SM00282
SMART
Laminin_G
IPR001791
InterPro
Laminin_G_1
PF00054
Pfam
SSF49899
SSF49899
SUPFAM
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