Protein: P04278

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P04278 (Uniprot) SHBG_HUMAN SHBG Sex hormone-binding globulin human No
Uniprot: Functions as an androgen transport protein, but may also be involved in receptor mediated processes. Each dimer binds one molecule of steroid. Specific for 5-alpha-dihydrotestosterone, testosterone, and 17-beta-estradiol. Regulates the plasma metabolic clearance rate of steroid hormones by controlling their plasma concentration. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 180 GO:0007165 signal transduction 831 4.22e-144 6.90e-18
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
238 GO:0060255 regulation of macromolecule metabolic process
240 GO:0019538 protein metabolic process
240 GO:0007165 signal transduction
259 GO:0007165 signal transduction
310 GO:0019538 protein metabolic process
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
831 GO:0007166 cell surface receptor signaling pathway
831 GO:0044271 cellular nitrogen compound biosynthetic process
831 GO:0006139 nucleobase-containing compound metabolic process
831 GO:0006796 phosphate-containing compound metabolic process
831 GO:0010646 regulation of cell communication
831 GO:0060255 regulation of macromolecule metabolic process
831 GO:0023051 regulation of signaling
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
18 GO:0005829 cytosol
18 GO:0070062 extracellular exosome
20 GO:0005886 plasma membrane
96 GO:0005654 nucleoplasm
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
238 GO:0005829 cytosol
238 GO:0005634 nucleus
240 GO:0005615 extracellular space
259 GO:0005886 plasma membrane
310 GO:0005829 cytosol
310 GO:0005634 nucleus
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
831 GO:0042995 cell projection
831 GO:0005829 cytosol
831 GO:0005634 nucleus
831 GO:0005886 plasma membrane
No results found.
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region NAS
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1400872 Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain.
2587256 Characterization of the human sex hormone binding globulin (SHBG) gene and demonstration of two transcripts in both liver and testis.
2608061 The human sex hormone-binding globulin gene contains exons for androgen-binding protein and two other testicular messenger RNAs.
2956125 Characterization of a cDNA coding for sex steroid-binding protein of human plasma.
2956126 A cDNA coding for human sex hormone binding globulin. Homology to vitamin K-dependent protein S.
3542030 Amino acid sequence of the sex steroid binding protein of human blood plasma.
3569533 The cDNA-deduced primary structure of human sex hormone-binding globulin and location of its steroid-binding domain.
3702459 Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits.
7714097 Molecular characterization of a genetic variant of the steroid hormone-binding globulin gene in heterozygous subjects.
10391209 Characterization of single-nucleotide polymorphisms in coding regions of human genes.
10675319 Crystal structure of human sex hormone-binding globulin: steroid transport by a laminin G-like domain.
12065592 Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation.
15028279 PCR isolation and cloning of novel splice variant mRNAs from known drug target genes.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
19159218 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
No results found.
Domain Name Domain ID Source
Laminin_G IPR001791 InterPro
ConA-like_dom_sf IPR013320 InterPro
Laminin_G_1 PF00054 Pfam
LAM_G_DOMAIN PS50025 PROSITE
BOHUS S09606 PIR
LamG SM00282 SMART
SSF49899 SSF49899 SUPFAM