Protein: P08621

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P08621 (Uniprot) RU17_HUMAN SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa human No
Uniprot: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 573, 674 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
720 GO:0006464 cellular protein modification process
720 GO:0071310 cellular response to organic substance
720 GO:0006355 regulation of transcription, DNA-templated
720 GO:0006366 transcription from RNA polymerase II promoter
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
96 GO:0005654 nucleoplasm
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
689 GO:0005654 nucleoplasm
720 GO:0005829 cytosol
720 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006397 mRNA processing TAS
GO:0008380 RNA splicing TAS
GO:0043462 regulation of ATPase activity TAS
GO:0043484 regulation of RNA splicing IMP
GO:0048026 positive regulation of mRNA splicing, via spliceosome IEA
GO:0061084 negative regulation of protein refolding TAS
GO:0071300 cellular response to retinoic acid IEA
GO:0071356 cellular response to tumor necrosis factor IEA
GO:0071560 cellular response to transforming growth factor beta stimulus IEA
GO:1904715 negative regulation of chaperone-mediated autophagy TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000243 commitment complex IBA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005681 spliceosomal complex IDA
GO:0005685 U1 snRNP IDA
GO:0005737 cytoplasm IEA
GO:0016607 nuclear speck IEA
GO:0071004 U2-type prespliceosome IBA
GO:0071011 precatalytic spliceosome IBA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
2147422 Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3.
2447561 The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.
2467746 A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
3028775 Cloning of the human cDNA for the U1 RNA-associated 70K protein.
8332490 Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
8746626 Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen.
9447963 Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.
9531537 A coactivator of pre-mRNA splicing.
10339552 The SRm160/300 splicing coactivator is required for exon-enhancer function.
11448987 ZNF265 -- a novel spliceosomal protein able to induce alternative splicing.
11514619 Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions.
14561889 Association of polyadenylation cleavage factor I with U1 snRNP.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14765198 Dephosphorylated SRp38 acts as a splicing repressor in response to heat shock.
15144186 Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17924679 Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19325628 Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
19369195 Large-scale proteomics analysis of the human kinome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25911097 Gemin5 binds to the survival motor neuron mRNA to regulate SMN expression.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A25707 A25707 PIR
RRM_dom IPR000504 InterPro
U1snRNP70_N IPR022023 InterPro
snRNP70_RRM IPR034143 InterPro
RBD_domain_sf IPR035979 InterPro
RRM_1 PF00076 Pfam
U1snRNP70_N PF12220 Pfam
RRM PS50102 PROSITE
S00674 S00674 PIR
RRM SM00360 SMART
SSF54928 SSF54928 SUPFAM
RRM_snRNP70 cd12236 CDD