Protein: P08621 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P08621 (Uniprot)	RU17_HUMAN	SNRNP70	U1 small nuclear ribonucleoprotein 70 kDa	human	No

Protein Function

Uniprot: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	573, 674	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
96	GO:0016070	RNA metabolic process
96	GO:0010467	gene expression
573	GO:0006464	cellular protein modification process
573	GO:0006139	nucleobase-containing compound metabolic process
573	GO:0060255	regulation of macromolecule metabolic process
573	GO:0007165	signal transduction
674	GO:0006464	cellular protein modification process
674	GO:0031324	negative regulation of cellular metabolic process
674	GO:0010605	negative regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
51	GO:0005634	nucleus
96	GO:0005654	nucleoplasm
573	GO:0005829	cytosol
573	GO:0012505	endomembrane system
573	GO:0070013	intracellular organelle lumen
573	GO:0044428	nuclear part
573	GO:0031982	vesicle
674	GO:0005829	cytosol
674	GO:0043232	intracellular non-membrane-bounded organelle
674	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006397	mRNA processing	TAS
GO:0008380	RNA splicing	TAS
GO:0043462	regulation of ATPase activity	TAS
GO:0043484	regulation of RNA splicing	IMP
GO:0048026	positive regulation of mRNA splicing, via spliceosome	IEA
GO:0061084	negative regulation of protein refolding	TAS
GO:0071300	cellular response to retinoic acid	IEA
GO:0071356	cellular response to tumor necrosis factor	IEA
GO:0071560	cellular response to transforming growth factor beta stimulus	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000243	commitment complex	IBA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005681	spliceosomal complex	IDA
GO:0005685	U1 snRNP	IDA
GO:0005737	cytoplasm	IEA
GO:0016607	nuclear speck	IEA
GO:0071004	U2-type prespliceosome	IBA
GO:0071011	precatalytic spliceosome	IBA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ANM5_HUMAN	No
CDKL3_HUMAN	No
CEP63_HUMAN	No
CHERP_HUMAN	Yes: Q8IWX8 (MoonDB)
CLK2_HUMAN	No
CSK21_HUMAN	Yes: P68400 (MoonDB)
GTPB2_HUMAN	No
IL32_HUMAN	No
KPCD2_HUMAN	No
LRP1_HUMAN	No

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Publications Associated

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PMID	Article Title
2147422	Human U1-70K ribonucleoprotein antigen gene: organization, nucleotide sequence, and mapping to locus 19q13.3.
2447561	The human U1-70K snRNP protein: cDNA cloning, chromosomal localization, expression, alternative splicing and RNA-binding.
2467746	A common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP protein.
3028775	Cloning of the human cDNA for the U1 RNA-associated 70K protein.
8332490	Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of splicing factors.
8746626	Identification of an inhibitory element within the human 68-kDa (U1) ribonucleoprotein antigen.
9447963	Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing.
9531537	A coactivator of pre-mRNA splicing.
10339552	The SRm160/300 splicing coactivator is required for exon-enhancer function.
11448987	ZNF265 -- a novel spliceosomal protein able to induce alternative splicing.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
A25707	A25707	PIR
RBD_domain_sf	IPR035979	InterPro
RRM	PS50102	PROSITE
RRM	SM00360	SMART
RRM_1	PF00076	Pfam
RRM_dom	IPR000504	InterPro
RRM_snRNP70	cd12236	CDD
S00674	S00674	PIR
snRNP70_RRM	IPR034143	InterPro
SSF54928	SSF54928	SUPFAM

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