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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q8IWX8
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q8IWX8 (Uniprot)
CHERP_HUMAN
CHERP
Calcium homeostasis endoplasmic reticulum protein
human
No
Protein Function
Uniprot:
Involved in calcium homeostasis, growth and proliferation.
MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0036211
protein modification process
483
GO:0016070
RNA metabolic process
689
5.81e-04
8.44e-05
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 16 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
96
GO:0016070
RNA metabolic process
96
GO:0010467
gene expression
124
GO:0010467
gene expression
124
GO:0090304
nucleic acid metabolic process
353
GO:0000398
mRNA splicing, via spliceosome
467
GO:0000398
mRNA splicing, via spliceosome
467
GO:0060255
regulation of macromolecule metabolic process
483
GO:0006464
cellular protein modification process
483
GO:0010467
gene expression
483
GO:0009059
macromolecule biosynthetic process
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Cellular Components
Showing 1 to 7 of 7 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
96
GO:0005654
nucleoplasm
124
GO:0031981
nuclear lumen
353
GO:0005654
nucleoplasm
467
GO:0005654
nucleoplasm
483
GO:0005829
cytosol
483
GO:0031981
nuclear lumen
689
GO:0005654
nucleoplasm
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Protein GO Annotations
Biological Processes
Showing 1 to 6 of 6 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000398
mRNA splicing, via spliceosome
TAS
GO:0006874
cellular calcium ion homeostasis
IDA
GO:0007399
nervous system development
TAS
GO:0008285
negative regulation of cell proliferation
IDA
GO:0051209
release of sequestered calcium ion into cytosol
IMP
GO:0051533
positive regulation of NFAT protein import into nucleus
IMP
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005654
nucleoplasm
TAS
GO:0005737
cytoplasm
IDA
GO:0016020
membrane
IDA
GO:0033017
sarcoplasmic reticulum membrane
ISS
GO:0048471
perinuclear region of cytoplasm
IDA
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Dissimilar Cellular Components (PrOnto)
Showing 1 to 1 of 1 entries
Search:
GO ID 1
Component 1
GO ID 2
Component 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0005654
nucleoplasm
GO:0016020
membrane
5.76e-255
1.32e-206
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All Protein Interactions
Showing 1 to 10 of 42 entries
Search:
Interactor
Also a MoonDB EMF protein
AGGF1_HUMAN
No
ARGL1_HUMAN
No
ATL4_HUMAN
No
CA094_HUMAN
No
CCAR1_HUMAN
No
DHX8_HUMAN
No
EWS_HUMAN
No
F10C1_HUMAN
No
FASTK_HUMAN
No
FIGN_HUMAN
No
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Publications Associated
Showing 1 to 10 of 16 entries
Search:
PMID
Article Title
8010949
Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein.
8896557
Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.
10794731
Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation.
12656674
Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes.
15057824
The DNA sequence and biology of human chromosome 19.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648
A quantitative atlas of mitotic phosphorylation.
19413330
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 16 entries
Search:
Domain Name
Domain ID
Source
CID
PS51391
PROSITE
CID_dom
IPR006569
InterPro
CTD_bind
PF04818
Pfam
ENTH_VHS
IPR008942
InterPro
G-patch
PF01585
Pfam
G_PATCH
PS50174
PROSITE
G_patch
SM00443
SMART
G_patch_dom
IPR000467
InterPro
RNA_pol_II-bd
IPR006903
InterPro
SSF109905
SSF109905
SUPFAM
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