UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8IWX8 (Uniprot)	CHERP_HUMAN	CHERP	Calcium homeostasis endoplasmic reticulum protein	human	No

Protein Function

Uniprot: Involved in calcium homeostasis, growth and proliferation.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0036211	protein modification process	483	GO:0016070	RNA metabolic process	689	5.81e-04	8.44e-05

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 16 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
96	GO:0016070	RNA metabolic process
96	GO:0010467	gene expression
124	GO:0010467	gene expression
124	GO:0090304	nucleic acid metabolic process
353	GO:0000398	mRNA splicing, via spliceosome
467	GO:0000398	mRNA splicing, via spliceosome
467	GO:0060255	regulation of macromolecule metabolic process
483	GO:0006464	cellular protein modification process
483	GO:0010467	gene expression
483	GO:0009059	macromolecule biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
96	GO:0005654	nucleoplasm
124	GO:0031981	nuclear lumen
353	GO:0005654	nucleoplasm
467	GO:0005654	nucleoplasm
483	GO:0005829	cytosol
483	GO:0031981	nuclear lumen
689	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

Showing 1 to 6 of 6 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000398	mRNA splicing, via spliceosome	TAS
GO:0006874	cellular calcium ion homeostasis	IDA
GO:0007399	nervous system development	TAS
GO:0008285	negative regulation of cell proliferation	IDA
GO:0051209	release of sequestered calcium ion into cytosol	IMP
GO:0051533	positive regulation of NFAT protein import into nucleus	IMP

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0016020	membrane	IDA
GO:0033017	sarcoplasmic reticulum membrane	ISS
GO:0048471	perinuclear region of cytoplasm	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206

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All Protein Interactions

Showing 1 to 10 of 42 entries

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Interactor	Also a MoonDB EMF protein
AGGF1_HUMAN	No
ARGL1_HUMAN	No
ATL4_HUMAN	No
CA094_HUMAN	No
CCAR1_HUMAN	No
DHX8_HUMAN	No
EWS_HUMAN	No
F10C1_HUMAN	No
FASTK_HUMAN	No
FIGN_HUMAN	No

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Publications Associated

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PMID	Article Title
8010949	Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein.
8896557	Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.
10794731	Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation.
12656674	Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes.
15057824	The DNA sequence and biology of human chromosome 19.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861	Lysine acetylation targets protein complexes and co-regulates major cellular functions.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 16 entries

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Domain Name	Domain ID	Source
CID	PS51391	PROSITE
CID_dom	IPR006569	InterPro
CTD_bind	PF04818	Pfam
ENTH_VHS	IPR008942	InterPro
G-patch	PF01585	Pfam
G_PATCH	PS50174	PROSITE
G_patch	SM00443	SMART
G_patch_dom	IPR000467	InterPro
RNA_pol_II-bd	IPR006903	InterPro
SSF109905	SSF109905	SUPFAM

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