Protein: Q8IWX8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8IWX8 (Uniprot) CHERP_HUMAN CHERP Calcium homeostasis endoplasmic reticulum protein human No
Uniprot: Involved in calcium homeostasis, growth and proliferation.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 483 GO:0016070 RNA metabolic process 689 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
96 GO:0016070 RNA metabolic process
96 GO:0010467 gene expression
124 GO:0010467 gene expression
124 GO:0090304 nucleic acid metabolic process
353 GO:0000398 mRNA splicing, via spliceosome
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
483 GO:0006464 cellular protein modification process
483 GO:0010467 gene expression
483 GO:0009059 macromolecule biosynthetic process
483 GO:0090304 nucleic acid metabolic process
483 GO:0060255 regulation of macromolecule metabolic process
483 GO:0007165 signal transduction
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
96 GO:0005654 nucleoplasm
124 GO:0031981 nuclear lumen
353 GO:0005654 nucleoplasm
467 GO:0005654 nucleoplasm
483 GO:0005829 cytosol
483 GO:0031981 nuclear lumen
689 GO:0005654 nucleoplasm
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006874 cellular calcium ion homeostasis IDA
GO:0007399 nervous system development TAS
GO:0008285 negative regulation of cell proliferation IDA
GO:0051209 release of sequestered calcium ion into cytosol IMP
GO:0051533 positive regulation of NFAT protein import into nucleus IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0016020 membrane IDA
GO:0033017 sarcoplasmic reticulum membrane ISS
GO:0048471 perinuclear region of cytoplasm IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
PMID Article Title
8010949 Ca2+ release by inositol 1,4,5-trisphosphate is blocked by the K(+)-channel blockers apamin and tetrapentylammonium ion, and a monoclonal antibody to a 63 kDa membrane protein: reversal of blockade by K+ ionophores nigericin and valinomycin and purification of the 63 kDa antibody-binding protein.
8896557 Cloning of the gene for spinocerebellar ataxia 2 reveals a locus with high sensitivity to expanded CAG/glutamine repeats.
10794731 Cloning of human Ca2+ homoeostasis endoplasmic reticulum protein (CHERP): regulated expression of antisense cDNA depletes CHERP, inhibits intracellular Ca2+ mobilization and decreases cell proliferation.
12656674 Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytes.
15057824 The DNA sequence and biology of human chromosome 19.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
Surp IPR000061 InterPro
G_patch_dom IPR000467 InterPro
CID_dom IPR006569 InterPro
RNA_pol_II-bd IPR006903 InterPro
ENTH_VHS IPR008942 InterPro
SWAP/Surp_sf IPR035967 InterPro
G-patch PF01585 Pfam
Surp PF01805 Pfam
CTD_bind PF04818 Pfam
SURP PS50128 PROSITE
G_PATCH PS50174 PROSITE
CID PS51391 PROSITE
G_patch SM00443 SMART
SWAP SM00648 SMART
SSF109905 SSF109905 SUPFAM
SSF48464 SSF48464 SUPFAM