Protein: Q8TAD8 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8TAD8 (Uniprot)	SNIP1_HUMAN	SNIP1	Smad nuclear-interacting protein 1	human	No

Protein Function

Uniprot: Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	194	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	353	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
47	GO:0044271	cellular nitrogen compound biosynthetic process
47	GO:0051252	regulation of RNA metabolic process
47	GO:0010468	regulation of gene expression
194	GO:0044267	cellular protein metabolic process
194	GO:0006355	regulation of transcription, DNA-templated
353	GO:0000398	mRNA splicing, via spliceosome
384	GO:0034645	cellular macromolecule biosynthetic process
384	GO:0006464	cellular protein modification process
384	GO:0090304	nucleic acid metabolic process
384	GO:0031326	regulation of cellular biosynthetic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
47	GO:0005654	nucleoplasm
91	GO:0005576	extracellular region
194	GO:0043232	intracellular non-membrane-bounded organelle
194	GO:0031981	nuclear lumen
353	GO:0005654	nucleoplasm
384	GO:0005829	cytosol
384	GO:0031981	nuclear lumen
413	GO:0005654	nucleoplasm
720	GO:0005829	cytosol
720	GO:0005654	nucleoplasm

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006355	regulation of transcription, DNA-templated	IEA
GO:0007249	I-kappaB kinase/NF-kappaB signaling	IEA
GO:0035196	production of miRNAs involved in gene silencing by miRNA	IMP
GO:1903955	positive regulation of protein targeting to mitochondrion	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IBA
GO:0005654	nucleoplasm	IDA
GO:0005829	cytosol	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
CDK6_HUMAN	Yes: Q00534 (MoonDB)
CHERP_HUMAN	Yes: Q8IWX8 (MoonDB)
CLK2_HUMAN	No
CLK3_HUMAN	No
DVL2_HUMAN	No
DVL3_HUMAN	Yes: Q92997 (MoonDB)
EIF3C_HUMAN	No
ERR3_HUMAN	No
FAF1_HUMAN	No
GMEB1_HUMAN	No

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Publications Associated

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PMID	Article Title
10887155	A novel Smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction.
11567019	SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators.
12097147	A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs).
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15378006	The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16371476	PDSM, a motif for phosphorylation-dependent SUMO modification.
17081983	Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18632581	The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis.
18669648	A quantitative atlas of mitotic phosphorylation.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614501	Psychomotor retardation, epilepsy, and craniofacial dysmorphism

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Protein Domains Associated

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Domain Name	Domain ID	Source
FHA	PF00498	Pfam
FHA	SM00240	SMART
FHA	cd00060	CDD
FHA_dom	IPR000253	InterPro
FHA_DOMAIN	PS50006	PROSITE
SMAD_FHA_dom_sf	IPR008984	InterPro
SSF49879	SSF49879	SUPFAM

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