Protein: Q15797 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15797 (Uniprot)	SMAD1_HUMAN	SMAD1	Mothers against decapentaplegic homolog 1	human	No

Protein Function

Uniprot: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)-mediat more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	255	GO:0006725	cellular aromatic compound metabolic process	395	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
29	GO:0060255	regulation of macromolecule metabolic process
29	GO:0007165	signal transduction
44	GO:0010467	gene expression
44	GO:0031324	negative regulation of cellular metabolic process
44	GO:0009889	regulation of biosynthetic process
44	GO:0060255	regulation of macromolecule metabolic process
51	GO:0060255	regulation of macromolecule metabolic process
54	GO:0010467	gene expression
54	GO:0006139	nucleobase-containing compound metabolic process
54	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
29	GO:0005634	nucleus
44	GO:0005829	cytosol
44	GO:0005634	nucleus
51	GO:0005634	nucleus
54	GO:0070013	intracellular organelle lumen
54	GO:0005634	nucleus
134	GO:0005829	cytosol
134	GO:0005634	nucleus
165	GO:0005829	cytosol
165	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	IEA
GO:0001657	ureteric bud development	IEA
GO:0001710	mesodermal cell fate commitment	IEA
GO:0002051	osteoblast fate commitment	IEA
GO:0006366	transcription from RNA polymerase II promoter	IEA
GO:0006954	inflammatory response	IEA
GO:0007165	signal transduction	NAS
GO:0007179	transforming growth factor beta receptor signaling pathway	NAS
GO:0007183	SMAD protein complex assembly	IDA
GO:0007276	gamete generation	IEA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005622	intracellular	NAS
GO:0005634	nucleus	NAS
GO:0005637	nuclear inner membrane	IDA
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	IEA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0016021	integral component of membrane	NAS
GO:0043234	protein complex	IDA
GO:0071141	SMAD protein complex	NAS

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005622	intracellular	GO:0016021	integral component of membrane	0.00e+00	4.07e-291
GO:0005634	nucleus	GO:0016021	integral component of membrane	0.00e+00	0.00e+00
GO:0005654	nucleoplasm	GO:0016021	integral component of membrane	0.00e+00	0.00e+00
GO:0005667	transcription factor complex	GO:0005737	cytoplasm	9.09e-11	9.47e-68
GO:0005667	transcription factor complex	GO:0016021	integral component of membrane	2.72e-38	1.02e-158
GO:0005737	cytoplasm	GO:0016021	integral component of membrane	2.01e-156	1.16e-04
GO:0005829	cytosol	GO:0016021	integral component of membrane	0.00e+00	0.00e+00
GO:0016021	integral component of membrane	GO:0043234	protein complex	6.03e-79	2.03e-37

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ALDR_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANR27_HUMAN	No
AP2A2_HUMAN	No
APC_HUMAN	No
AXIN2_HUMAN	No
BMR1A_HUMAN	No
BUB1_HUMAN	No
CAMP1_HUMAN	No
CASL_HUMAN	No

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Publications Associated

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PMID	Article Title
8637600	A human Mad protein acting as a BMP-regulated transcriptional activator.
8653785	MADR1, a MAD-related protein that functions in BMP2 signaling pathways.
8663601	Serine phosphorylation, chromosomal localization, and transforming growth factor-beta signal transduction by human bsp-1.
8673135	Mad-related genes in the human.
8774881	Receptor-associated Mad homologues synergize as effectors of the TGF-beta response.
9136927	The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.
9759503	TGF-beta signal transduction.
10647776	Remarkable versatility of Smad proteins in the nucleus of transforming growth factor-beta activated cells.
10660046	OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways.
10708948	The Smad pathway.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
DWA	SM00523	SMART
Dwarfin	IPR013790	InterPro
DWB	SM00524	SMART
MAD_homology1_Dwarfin-type	IPR003619	InterPro
MAD_homology_MH1	IPR013019	InterPro
MH1	PF03165	Pfam
MH1	PS51075	PROSITE
MH2	PF03166	Pfam
MH2	PS51076	PROSITE
PTHR13703	PTHR13703	PANTHER

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