Protein: Q9UNE7 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9UNE7 (Uniprot)	CHIP_HUMAN	STUB1	E3 ubiquitin-protein ligase CHIP	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquiti more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	192, 485, 551	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
155	GO:0006464	cellular protein modification process
155	GO:0060255	regulation of macromolecule metabolic process
192	GO:0034645	cellular macromolecule biosynthetic process
192	GO:0006464	cellular protein modification process
192	GO:0010467	gene expression
192	GO:0090304	nucleic acid metabolic process
192	GO:0009893	positive regulation of metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
155	GO:0005634	nucleus
162	GO:0005634	nucleus
192	GO:0005829	cytosol
192	GO:0005654	nucleoplasm
237	GO:0005829	cytosol
237	GO:0012505	endomembrane system
237	GO:0005615	extracellular space
237	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000209	protein polyubiquitination	IMP
GO:0006281	DNA repair	IEA
GO:0006511	ubiquitin-dependent protein catabolic process	IMP
GO:0006515	protein quality control for misfolded or incompletely synthesized proteins	IDA
GO:0016567	protein ubiquitination	IMP
GO:0030433	ubiquitin-dependent ERAD pathway	IEA
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	TAS
GO:0030579	ubiquitin-dependent SMAD protein catabolic process	IDA
GO:0030968	endoplasmic reticulum unfolded protein response	IEA
GO:0031398	positive regulation of protein ubiquitination	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000151	ubiquitin ligase complex	IDA
GO:0005654	nucleoplasm	IDA
GO:0005737	cytoplasm	IDA
GO:0005783	endoplasmic reticulum	IDA
GO:0005829	cytosol	TAS
GO:0030018	Z disc	IEA
GO:0031371	ubiquitin conjugating enzyme complex	TAS
GO:0042405	nuclear inclusion body	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005654	nucleoplasm	GO:0005783	endoplasmic reticulum	1.84e-53	1.21e-118
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ACD_HUMAN	Yes: Q96AP0 (MoonDB)
AGO2_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ANM5_HUMAN	No
ARIP4_HUMAN	No
ATCAY_HUMAN	No
B4DE84_HUMAN	No
BAG1_HUMAN	No
BAG2_HUMAN	No
BAG3_HUMAN	No

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Publications Associated

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PMID	Article Title
9610721	Characterization of human colon cancer antigens recognized by autologous antibodies.
10330192	Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions.
11146632	The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins.
11157797	Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.
11435423	U box proteins as a new family of ubiquitin-protein ligases.
11557750	CHIP is a U-box-dependent E3 ubiquitin ligase: identification of Hsc70 as a target for ubiquitylation.
12200376	Identification of tumor-associated antigens in chronic lymphocytic leukemia by SEREX.
15215316	The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.
15466472	Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

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OMIM Diseases Associated

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OMIM ID	Disease Name
615768	Spinocerebellar ataxia, autosomal recessive, 16

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Protein Domains Associated

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Domain Name	Domain ID	Source
SSF48452	SSF48452	SUPFAM
TPR	PS50005	PROSITE
TPR	SM00028	SMART
TPR-contain_dom	IPR013026	InterPro
TPR-like_helical_dom_sf	IPR011990	InterPro
TPR_REGION	PS50293	PROSITE
TPR_repeat	IPR019734	InterPro
U-box	PF04564	Pfam
U_BOX	PS51698	PROSITE
Ubox	SM00504	SMART

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