Protein: P01023 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P01023 (Uniprot)	A2MG_HUMAN	A2M	Alpha-2-macroglobulin	human	No

Protein Function

Uniprot: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which tra more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006139	nucleobase-containing compound metabolic process	27	GO:0007165	signal transduction	803	1.10e-111	5.07e-25
GO:0034641	cellular nitrogen compound metabolic process	267	GO:0007165	signal transduction	803	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
27	GO:0090304	nucleic acid metabolic process
27	GO:0060255	regulation of macromolecule metabolic process
129	GO:0044267	cellular protein metabolic process
129	GO:0007165	signal transduction
170	GO:0070887	cellular response to chemical stimulus
170	GO:0034654	nucleobase-containing compound biosynthetic process
170	GO:0031326	regulation of cellular biosynthetic process
170	GO:0010468	regulation of gene expression
170	GO:0007165	signal transduction
198	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
18	GO:0005829	cytosol
18	GO:0070062	extracellular exosome
27	GO:0031981	nuclear lumen
129	GO:0005829	cytosol
129	GO:0070013	intracellular organelle lumen
136	GO:0005829	cytosol
136	GO:0005634	nucleus
148	GO:0005829	cytosol
170	GO:0005634	nucleus
198	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001869	negative regulation of complement activation, lectin pathway	IDA
GO:0002576	platelet degranulation	TAS
GO:0007597	blood coagulation, intrinsic pathway	TAS
GO:0010951	negative regulation of endopeptidase activity	IEA
GO:0022617	extracellular matrix disassembly	TAS
GO:0043547	positive regulation of GTPase activity	IEA
GO:0048863	stem cell differentiation	IEA
GO:0051056	regulation of small GTPase mediated signal transduction	TAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005829	cytosol	TAS
GO:0031093	platelet alpha granule lumen	TAS
GO:0070062	extracellular exosome	IDA
GO:0072562	blood microparticle	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
A4_HUMAN	No
ACTB_HUMAN	No
ANXA7_HUMAN	No
AP1M2_HUMAN	No
APOE_HUMAN	Yes: P02649 (MoonDB)
AT1A1_HUMAN	No
CDC37_HUMAN	Yes: Q16543 (MoonDB)
CDC42_HUMAN	Yes: P60953 (MoonDB)
CDKA2_HUMAN	No
CDN1A_HUMAN	Yes: P38936 (MoonDB)

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Publications Associated

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PMID	Article Title
1370808	Cloning of the human alpha 2-macroglobulin gene and detection of mutations in two functional domains: the bait region and the thiolester site.
1374237	Structure of the human alpha-2 macroglobulin gene and its promotor.
1692292	A genetic polymorphism in a functional domain of human pregnancy zone protein: the bait region. Genomic structure of the bait domains of human pregnancy zone protein and alpha 2 macroglobulin.
1707161	Sequence polymorphism in the human alpha2-macroglobulin (A2M) gene.
2408344	Human alpha 2-macroglobulin gene is located on chromosome 12.
2430963	Primary structure of human alpha 2-macroglobulin. Complete disulfide bridge assignment and localization of two interchain bridges in the dimeric proteinase binding unit.
2581245	Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.
6165619	Primary structure of the 'bait' region for proteinases in alpha 2-macroglobulin. Nature of the complex.
6167263	Proteolytic cleavage sites on alpha 2-macroglobulin resulting in proteinase binding are different for trypsin and Staphylococcus aureus V-8 proteinase.
6172288	Primary and secondary cleavage sites in the bait region of alpha 2-macroglobulin.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 26 entries

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Domain Name	Domain ID	Source
A-macroglobulin_rcpt-bd	IPR009048	InterPro
A-macroglobulin_rcpt-bd_sf	IPR036595	InterPro
A2M	PF00207	Pfam
A2M	SM01360	SMART
A2M_comp	IPR011626	InterPro
A2M_comp	PF07678	Pfam
A2M_N	IPR002890	InterPro
A2M_N	PF01835	Pfam
A2M_N_2	IPR011625	InterPro
A2M_N_2	PF07703	Pfam

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