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A Database of Extreme Multifunctional and Moonlighting Proteins
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About
Protein: Q8WV44
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q8WV44 (Uniprot)
TRI41_HUMAN
TRIM41
E3 ubiquitin-protein ligase TRIM41
human
No
Protein Function
Uniprot:
Functions as an E3 ligase that catalyzes the ubiquitin-mediated degradation of protein kinase C.
MoonDB Dissimilar Functions
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006139
nucleobase-containing compound metabolic process
63
,
572
GO:0033036
macromolecule localization
748
4.58e-19
9.70e-72
GO:0044260
cellular macromolecule metabolic process
127
,
340
,
649
,
661
GO:0033036
macromolecule localization
748
4.56e-06
3.25e-28
MoonDB Network Modules
Biological Processes
Module ID
(MoonGO)
GO ID (BP)
GO Name
63
GO:0010467
gene expression
63
GO:0090304
nucleic acid metabolic process
63
GO:0060255
regulation of macromolecule metabolic process
80
GO:0051252
regulation of RNA metabolic process
80
GO:0010468
regulation of gene expression
127
GO:0016070
RNA metabolic process
127
GO:0010467
gene expression
151
GO:0060255
regulation of macromolecule metabolic process
160
GO:0006355
regulation of transcription, DNA-templated
191
GO:0006355
regulation of transcription, DNA-templated
268
GO:0006355
regulation of transcription, DNA-templated
340
GO:0016070
RNA metabolic process
340
GO:0010467
gene expression
340
GO:0060255
regulation of macromolecule metabolic process
478
GO:0060255
regulation of macromolecule metabolic process
572
GO:0090304
nucleic acid metabolic process
646
GO:0060255
regulation of macromolecule metabolic process
646
GO:0006351
transcription, DNA-templated
649
GO:0016070
RNA metabolic process
649
GO:0010468
regulation of gene expression
661
GO:0016070
RNA metabolic process
661
GO:0010467
gene expression
723
GO:0006464
cellular protein modification process
723
GO:0048585
negative regulation of response to stimulus
723
GO:0007165
signal transduction
748
GO:0008104
protein localization
834
GO:0051252
regulation of RNA metabolic process
834
GO:2000112
regulation of cellular macromolecule biosynthetic process
834
GO:0010468
regulation of gene expression
834
GO:0006351
transcription, DNA-templated
Cellular Components
Module ID
(MoonGO)
GO ID (CC)
GO Name
63
GO:0005634
nucleus
80
GO:0005634
nucleus
84
GO:0005634
nucleus
89
GO:0005634
nucleus
127
GO:0005634
nucleus
151
GO:0005634
nucleus
160
GO:0005634
nucleus
190
GO:0005829
cytosol
190
GO:0043232
intracellular non-membrane-bounded organelle
191
GO:0031981
nuclear lumen
226
GO:0005634
nucleus
260
GO:0005829
cytosol
268
GO:0005634
nucleus
340
GO:0005634
nucleus
478
GO:0005634
nucleus
567
GO:0005634
nucleus
572
GO:0005634
nucleus
639
GO:0005634
nucleus
646
GO:0005856
cytoskeleton
646
GO:0005634
nucleus
649
GO:0070013
intracellular organelle lumen
649
GO:0005634
nucleus
661
GO:0005654
nucleoplasm
723
GO:0044428
nuclear part
748
GO:0005815
microtubule organizing center
748
GO:0005634
nucleus
834
GO:0005634
nucleus
Protein GO Annotations
Biological Processes
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0016567
protein ubiquitination
IEA
Cellular Components
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005730
nucleolus
IDA
GO:0005737
cytoplasm
IEA
GO:0016604
nuclear body
IDA
Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Interactor
Also a MoonDB EMF protein
PRP31_HUMAN
No
KR108_HUMAN
No
KR109_HUMAN
Yes:
P60411 (MoonDB)
G2XKQ0_HUMAN
No
FAM9A_HUMAN
No
ZN526_HUMAN
No
MEOX2_HUMAN
Yes:
P50222 (MoonDB)
CCNL2_HUMAN
No
ZN408_HUMAN
No
VINEX_HUMAN
No
ZBT8A_HUMAN
No
ZN837_HUMAN
No
KIFC3_HUMAN
No
KTBL1_HUMAN
No
AES_HUMAN
Yes:
Q08117 (MoonDB)
MO4L1_HUMAN
No
AP1M1_HUMAN
No
ZBT24_HUMAN
No
CSK21_HUMAN
Yes:
P68400 (MoonDB)
BYST_HUMAN
No
TCEA2_HUMAN
No
TEANC_HUMAN
No
GMCLL_HUMAN
No
SYTL4_HUMAN
No
ZN417_HUMAN
Yes:
Q8TAU3 (MoonDB)
NCK2_HUMAN
Yes:
O43639 (MoonDB)
HS90B_HUMAN
Yes:
P08238 (MoonDB)
NEMO_HUMAN
Yes:
Q9Y6K9 (MoonDB)
FTM_HUMAN
No
GOR_HUMAN
No
AQP1_HUMAN
No
ZSC26_HUMAN
No
F161A_HUMAN
No
ZN648_HUMAN
No
MCRS1_HUMAN
No
ZN587_HUMAN
No
ZBT38_HUMAN
No
TRIM1_HUMAN
Yes:
Q9UJV3 (MoonDB)
ZN490_HUMAN
No
CE128_HUMAN
Yes:
Q6ZU80 (MoonDB)
SUV91_HUMAN
No
ZN264_HUMAN
No
ZN250_HUMAN
No
ZN165_HUMAN
No
MFAP1_HUMAN
No
RNPS1_HUMAN
No
ZN792_HUMAN
No
ZFP1_HUMAN
No
ZN497_HUMAN
No
ZN329_HUMAN
No
Q86XJ5_HUMAN
No
ZNF48_HUMAN
No
ZN696_HUMAN
No
CEP44_HUMAN
No
ANR28_HUMAN
No
Z286A_HUMAN
No
STX11_HUMAN
No
CAR10_HUMAN
No
GAS8_HUMAN
No
ZN266_HUMAN
No
ZN575_HUMAN
No
ZN439_HUMAN
No
DVL3_HUMAN
Yes:
Q92997 (MoonDB)
GPT2L_HUMAN
No
ZN319_HUMAN
No
UBC9_HUMAN
Yes:
P63279 (MoonDB)
TRAIP_HUMAN
No
TRI17_HUMAN
No
PLAL2_HUMAN
No
AEN_HUMAN
No
F10C1_HUMAN
No
AKTIP_HUMAN
No
AL2SB_HUMAN
No
BRAP_HUMAN
No
CH033_HUMAN
No
CHD2_HUMAN
No
CSK22_HUMAN
No
CX067_HUMAN
No
DPTOR_HUMAN
No
ECHP_HUMAN
No
F124A_HUMAN
No
MAGH1_HUMAN
No
MEOX1_HUMAN
No
MO4L2_HUMAN
No
MOBP_HUMAN
No
MPP3_HUMAN
No
PHC2_HUMAN
Yes:
Q8IXK0 (MoonDB)
PHF7_HUMAN
No
PRD14_HUMAN
No
PTN3_HUMAN
No
PUS7L_HUMAN
No
RBAK_HUMAN
No
SRPK2_HUMAN
Yes:
P78362 (MoonDB)
SYCE1_HUMAN
No
TOP3B_HUMAN
No
TRI26_HUMAN
No
TRI52_HUMAN
No
TRIM4_HUMAN
No
TZAP_HUMAN
No
Z780A_HUMAN
No
ZBT26_HUMAN
No
ZBT39_HUMAN
No
ZCHC7_HUMAN
No
ZF64A_HUMAN
No
ZF64B_HUMAN
No
ZFP2_HUMAN
No
ZN121_HUMAN
No
ZN138_HUMAN
No
ZN219_HUMAN
No
ZN263_HUMAN
No
ZN398_HUMAN
No
ZN460_HUMAN
No
ZN473_HUMAN
No
ZN564_HUMAN
No
ZN653_HUMAN
No
ZN655_HUMAN
No
ZN670_HUMAN
No
ZN691_HUMAN
No
ZN784_HUMAN
No
ZNF24_HUMAN
No
ZNF26_HUMAN
No
ZNF2_HUMAN
No
ZNF71_HUMAN
No
ZSC21_HUMAN
No
Publications Associated
PMID
Article Title
11549288
M phase-specific association of human topoisomerase IIIbeta with chromosomes.
14702039
Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15498874
Large-scale cDNA transfection screening for genes related to cancer development and progression.
16022281
Intracellular localization and domain organization of human TRIM41 proteins.
17893151
Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase.
20068231
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
24275569
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25218447
Uncovering global SUMOylation signaling networks in a site-specific manner.
OMIM Diseases Associated
No results found.
Protein Domains Associated
Domain Name
Domain ID
Source
Znf_B-box
IPR000315
InterPro
Znf_RING
IPR001841
InterPro
B30.2/SPRY
IPR001870
InterPro
SPRY_dom
IPR003877
InterPro
Butyrophylin_SPRY
IPR003879
InterPro
PRY
IPR006574
InterPro
Znf_RING/FYVE/PHD
IPR013083
InterPro
ConA-like_dom_sf
IPR013320
InterPro
Znf_RING_CS
IPR017907
InterPro
SPRY
PF00622
Pfam
zf-B_box
PF00643
Pfam
PRY
PF13765
Pfam
BUTYPHLNCDUF
PR01407
PRINTS
ZF_RING_1
PS00518
PROSITE
ZF_RING_2
PS50089
PROSITE
ZF_BBOX
PS50119
PROSITE
B302_SPRY
PS50188
PROSITE
RING
SM00184
SMART
BBOX
SM00336
SMART
SPRY
SM00449
SMART
PRY
SM00589
SMART
SSF49899
SSF49899
SUPFAM
BBOX
cd00021
CDD