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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q96RG2
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q96RG2 (Uniprot)
PASK_HUMAN
PASK
PAS domain-containing serine/threonine-protein kinase
human
No
Protein Function
Uniprot:
Serine/threonine-protein kinase involved in energy homeostasis and protein translation. Phosphorylates EEF1A1, GYS1, PDX1 and RPS6. Probably plays a role under changing environmental conditions (oxygen, glucose, nutrition), rather than under standard conditions. Acts as a sensor involved in energy homeostasis: re
gulates glycogen synthase synthesis by mediating phosphorylation of GYS1, leading to GYS1 inactivation. May be involved in glucose-stimulated insulin production in pancreas and regulation of glucagon secretion by glucose in alpha cells; however such data require additional evidences. May play a role in regulation of protein translation by phosphorylating EEF1A1, leading to increase translation efficiency. May also participate to respiratory regulation.
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MoonDB Dissimilar Functions
Showing 1 to 1 of 1 entries
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0043170
macromolecule metabolic process
412
GO:0042886
amide transport
663
2.11e-04
2.73e-69
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MoonDB Network Modules
Biological Processes
Showing 1 to 7 of 7 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
178
GO:0060255
regulation of macromolecule metabolic process
178
GO:0007165
signal transduction
249
GO:0060255
regulation of macromolecule metabolic process
412
GO:0019538
protein metabolic process
412
GO:0060255
regulation of macromolecule metabolic process
663
GO:0015833
peptide transport
663
GO:0008104
protein localization
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Cellular Components
Showing 1 to 8 of 8 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
178
GO:0005634
nucleus
249
GO:0005829
cytosol
249
GO:0005634
nucleus
249
GO:0031982
vesicle
412
GO:0005829
cytosol
412
GO:0005634
nucleus
663
GO:0005829
cytosol
663
GO:0031982
vesicle
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Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006468
protein phosphorylation
IDA
GO:0043576
regulation of respiratory gaseous exchange
ISS
GO:0045719
negative regulation of glycogen biosynthetic process
IDA
GO:0045727
positive regulation of translation
TAS
GO:0046777
protein autophosphorylation
IDA
GO:0070092
regulation of glucagon secretion
ISS
GO:2000505
regulation of energy homeostasis
ISS
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Cellular Components
Showing 1 to 3 of 3 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0005634
nucleus
IDA
GO:0005737
cytoplasm
IDA
GO:0005829
cytosol
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 28 entries
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Interactor
Also a MoonDB EMF protein
4ET_HUMAN
No
B9D2_HUMAN
No
CEP44_HUMAN
No
CREB1_HUMAN
No
EF1A1_HUMAN
No
F261_HUMAN
No
FIBA_HUMAN
No
FRDA_HUMAN
No
GYS1_HUMAN
No
HS90B_HUMAN
Yes:
P08238 (MoonDB)
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Publications Associated
Showing 1 to 10 of 20 entries
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PMID
Article Title
8590280
Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.
9110174
Large-scale concatenation cDNA sequencing.
11459942
PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase.
12168954
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.
12377121
Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15815621
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16275910
Control of mammalian glycogen synthase by PAS kinase.
17052199
Regulation by Per-Arnt-Sim (PAS) kinase of pancreatic duodenal homeobox-1 nuclear import in pancreatic beta-cells.
17344846
Patterns of somatic mutation in human cancer genomes.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 19 entries
Search:
Domain Name
Domain ID
Source
Kinase-like_dom_sf
IPR011009
InterPro
PAS
IPR000014
InterPro
PAS
PS50112
PROSITE
PAS
SM00091
SMART
PAS
cd00130
CDD
PAS-like_dom_sf
IPR035965
InterPro
PAS_9
PF13426
Pfam
Pkinase
PF00069
Pfam
Prot_kinase_dom
IPR000719
InterPro
PROTEIN_KINASE_ATP
PS00107
PROSITE
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