Protein: P25788

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P25788 (Uniprot) PSA3_HUMAN PSMA3 Proteasome subunit alpha type-3 human No
Uniprot: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 106, 577 GO:0016070 RNA metabolic process 75 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
75 GO:0016071 mRNA metabolic process
75 GO:0051252 regulation of RNA metabolic process
75 GO:0010468 regulation of gene expression
75 GO:0006351 transcription, DNA-templated
76 GO:0007165 signal transduction
106 GO:0006464 cellular protein modification process
106 GO:0031325 positive regulation of cellular metabolic process
106 GO:0010604 positive regulation of macromolecule metabolic process
106 GO:0051173 positive regulation of nitrogen compound metabolic process
106 GO:0009966 regulation of signal transduction
106 GO:0006355 regulation of transcription, DNA-templated
139 GO:0023051 regulation of signaling
139 GO:0007165 signal transduction
209 GO:0031324 negative regulation of cellular metabolic process
209 GO:0010605 negative regulation of macromolecule metabolic process
209 GO:0051172 negative regulation of nitrogen compound metabolic process
209 GO:0009893 positive regulation of metabolic process
209 GO:0006357 regulation of transcription from RNA polymerase II promoter
209 GO:0007165 signal transduction
557 GO:0034645 cellular macromolecule biosynthetic process
557 GO:0044265 cellular macromolecule catabolic process
557 GO:0044271 cellular nitrogen compound biosynthetic process
557 GO:0035556 intracellular signal transduction
557 GO:0016071 mRNA metabolic process
557 GO:0010629 negative regulation of gene expression
557 GO:0031325 positive regulation of cellular metabolic process
557 GO:0051247 positive regulation of protein metabolic process
557 GO:0051252 regulation of RNA metabolic process
557 GO:0009894 regulation of catabolic process
557 GO:0031326 regulation of cellular biosynthetic process
557 GO:0010556 regulation of macromolecule biosynthetic process
557 GO:0031399 regulation of protein modification process
577 GO:0006464 cellular protein modification process
577 GO:0033554 cellular response to stress
577 GO:0006796 phosphate-containing compound metabolic process
577 GO:0031326 regulation of cellular biosynthetic process
577 GO:0010556 regulation of macromolecule biosynthetic process
577 GO:0009966 regulation of signal transduction
632 GO:0010467 gene expression
632 GO:0090304 nucleic acid metabolic process
632 GO:0060255 regulation of macromolecule metabolic process
632 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
64 GO:0005634 nucleus
65 GO:0012505 endomembrane system
65 GO:0016021 integral component of membrane
75 GO:0005829 cytosol
75 GO:0005654 nucleoplasm
76 GO:0005634 nucleus
106 GO:0005829 cytosol
106 GO:0005654 nucleoplasm
206 GO:0005829 cytosol
209 GO:0005654 nucleoplasm
260 GO:0005829 cytosol
389 GO:0012505 endomembrane system
389 GO:0016021 integral component of membrane
525 GO:0005829 cytosol
557 GO:0005829 cytosol
557 GO:0044421 extracellular region part
557 GO:0005654 nucleoplasm
557 GO:0031982 vesicle
577 GO:0005829 cytosol
577 GO:0043232 intracellular non-membrane-bounded organelle
577 GO:0070013 intracellular organelle lumen
577 GO:0044428 nuclear part
577 GO:0031982 vesicle
632 GO:0031981 nuclear lumen
641 GO:0005634 nucleus
666 GO:0016021 integral component of membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0000209 protein polyubiquitination TAS
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent TAS
GO:0006521 regulation of cellular amino acid metabolic process TAS
GO:0010972 negative regulation of G2/M transition of mitotic cell cycle TAS
GO:0016032 viral process IEA
GO:0016579 protein deubiquitination TAS
GO:0031145 anaphase-promoting complex-dependent catabolic process TAS
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process TAS
GO:0033209 tumor necrosis factor-mediated signaling pathway TAS
GO:0038061 NIK/NF-kappaB signaling TAS
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process TAS
GO:0043488 regulation of mRNA stability TAS
GO:0043687 post-translational protein modification TAS
GO:0050852 T cell receptor signaling pathway TAS
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle TAS
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition TAS
GO:0052548 regulation of endopeptidase activity IMP
GO:0055085 transmembrane transport TAS
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO:0090090 negative regulation of canonical Wnt signaling pathway TAS
GO:0090263 positive regulation of canonical Wnt signaling pathway TAS
GO:1902036 regulation of hematopoietic stem cell differentiation TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000502 proteasome complex IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm TAS
GO:0005829 cytosol TAS
GO:0005839 proteasome core complex IDA
GO:0019773 proteasome core complex, alpha-subunit complex ISS
GO:0045202 synapse IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0045202 synapse 1.10e-08 8.94e-15
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0045202 synapse 3.30e-10 4.22e-25
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
A0A024R5S0_HUMAN No
A0A024R857_HUMAN No
A0A087WX54_HUMAN No
AGRL1_HUMAN No
ANFB_HUMAN No
APEL_HUMAN No
APRIO_HUMAN No
ARIP4_HUMAN No
ATN1_HUMAN No
AURKB_HUMAN No
B2R550_HUMAN No
BT2A2_HUMAN No
CA105_HUMAN No
CCD69_HUMAN No
CCL28_HUMAN No
CDK6_HUMAN Yes: Q00534 (MoonDB)
CI106_HUMAN No
CQ113_HUMAN No
CRUM3_HUMAN No
CRYAB_HUMAN Yes: P02511 (MoonDB)
CSK21_HUMAN Yes: P68400 (MoonDB)
CTGE5_HUMAN No
CY24A_HUMAN No
CYTT_HUMAN No
DMC1_HUMAN No
DMRT3_HUMAN No
DVL1_HUMAN No
EGR1_HUMAN No
F1712_HUMAN No
F218A_HUMAN No
FA83A_HUMAN No
FBW1A_HUMAN No
FBX7_HUMAN No
FRAT1_HUMAN No
GATA2_HUMAN No
GATA3_HUMAN No
GFI1B_HUMAN No
GLUCM_HUMAN No
GORS2_HUMAN No
HSPB1_HUMAN Yes: P04792 (MoonDB)
HXA2_HUMAN No
IQCE_HUMAN No
KIAS3_HUMAN No
KIF1A_HUMAN No
KIRR2_HUMAN No
KR195_HUMAN No
KR261_HUMAN No
KRA81_HUMAN No
LASP1_HUMAN No
LBP_HUMAN No
LETM1_HUMAN No
MUM1_HUMAN No
NEMO_HUMAN Yes: Q9Y6K9 (MoonDB)
NEUR4_HUMAN No
NPBW2_HUMAN No
NUMBL_HUMAN No
OSR2_HUMAN No
PATL1_HUMAN No
PCOTH_HUMAN No
PLD3A_HUMAN No
PML_HUMAN No
POMP_HUMAN No
PRC2A_HUMAN No
PRIO_HUMAN Yes: P04156 (MoonDB)
PRR13_HUMAN No
PRR3_HUMAN No
PSA1_HUMAN No
PSA2_HUMAN No
PSA4_HUMAN No
PSA6_HUMAN No
PSA7_HUMAN No
PSB10_HUMAN No
PSB4_HUMAN No
PSB5_HUMAN No
PTN23_HUMAN No
PWP2B_HUMAN No
Q7KZQ1_HUMAN No
Q7L9D0_HUMAN No
Q8N0U1_HUMAN No
Q8N779_HUMAN No
Q96CW7_HUMAN No
Q96D16_HUMAN No
Q9H6H2_HUMAN No
Q9H8E5_HUMAN No
Q9HAA0_HUMAN No
Q9NWL9_HUMAN No
R3GEF_HUMAN No
RAM_HUMAN No
RASK_HUMAN No
RBM42_HUMAN No
RERE_HUMAN No
RFOX2_HUMAN No
RFT1_HUMAN No
RSMB_HUMAN No
RTP5_HUMAN No
RU1C_HUMAN No
RUAS1_HUMAN No
RUXF_HUMAN No
S22AN_HUMAN No
SERF2_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
SH3K1_HUMAN No
SLAI1_HUMAN No
SPAT8_HUMAN No
SRPK2_HUMAN Yes: P78362 (MoonDB)
STX11_HUMAN No
STX1A_HUMAN No
STX4_HUMAN No
STX6_HUMAN No
TBC16_HUMAN No
TBX6_HUMAN No
TF7L2_HUMAN No
TRIB3_HUMAN No
URAS1_HUMAN No
VATL_HUMAN No
VP37C_HUMAN Yes: A5D8V6 (MoonDB)
XRN2_HUMAN No
YPEL3_HUMAN No
YT011_HUMAN No
Z385C_HUMAN No
ZN366_HUMAN No
PMID Article Title
2025653 Molecular cloning and sequence analysis of cDNAs for five major subunits of human proteasomes (multi-catalytic proteinase complexes).
7811265 Human proteasome subunits from 2-dimensional gels identified by partial sequencing.
8610016 A role for the proteasome regulator PA28alpha in antigen presentation.
11350925 A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome.
11521686 Gene expression induced by BO-653, probucol and BHQ in human endothelial cells.
12181345 Clastosome: a subtype of nuclear body enriched in 19S and 20S proteasomes, ubiquitin, and protein substrates of proteasome.
12376572 Mapping and structural dissection of human 20 s proteasome using proteomic approaches.
12472671 Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes.
14550573 Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits.
14674694 Human Aurora-B binds to a proteasome alpha-subunit HC8 and undergoes degradation in a proteasome-dependent manner.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15244466 20S proteasome prevents aggregation of heat-denatured proteins without PA700 regulatory subcomplex like a molecular chaperone.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15831937 Epstein-Barr virus EBNA3 proteins bind to the C8/alpha7 subunit of the 20S proteasome and are degraded by 20S proteasomes in vitro, but are very stable in latently infected B cells.
15936278 HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome.
16298756 Chemical structure-dependent gene expression of proteasome subunits via regulation of the antioxidant response element.
16337594 MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17323924 Mass spectrometric characterization of the affinity-purified human 26S proteasome complex.
17487921 Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line.
17499743 Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes.
18318008 Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.
18669648 A quantitative atlas of mitotic phosphorylation.
18971267 Ubiquitin-independent degradation of hepatitis C virus F protein.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25599644 Crystal structure of the human 20S proteasome in complex with carfilzomib.
26133119 Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core.
26524591 Additive loss-of-function proteasome subunit mutations in CANDLE/PRAAS patients promote type I IFN production.
26657688 Disassembly of the self-assembled, double-ring structure of proteasome alpha7 homo-tetradecamer by alpha6.
27176742 Human 20S proteasome activity towards fluorogenic peptides of various chain lengths.
27342858 Structure of the human 26S proteasome at a resolution of 3.9 Aa.
27428775 An atomic structure of the human 26S proteasome.
27493187 The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
No results found.
Domain Name Domain ID Source
Proteasome_asu_N IPR000426 InterPro
Proteasome_sua/b IPR001353 InterPro
Proteasome_alpha-type IPR023332 InterPro
Ntn_hydrolases_N IPR029055 InterPro
Proteasome PF00227 Pfam
Proteasome_A_N PF10584 Pfam
PROTEASOME_ALPHA_1 PS00388 PROSITE
PROTEASOME_ALPHA_2 PS51475 PROSITE
SNHUC8 S15971 PIR
Proteasome_A_N SM00948 SMART
SSF56235 SSF56235 SUPFAM