Protein: Q8NEU8

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8NEU8 (Uniprot) DP13B_HUMAN APPL2 DCC-interacting protein 13-beta human Yes
Uniprot: Required for the regulation of cell proliferation in response to extracellular signals mediated by an early endosomal compartment. Links Rab5 to nuclear signal transduction.
Dissimilar Functions Manual Curation

Function 1: Endocytic function. Links Rab5 to nuclear signal transduction. Condition: cytoplasm localisation.

Function 2: Nucleosome remodelling, transcription regulation. Condition: nuclear localisation.

Publications (PMID): 15016378, 15261672, 19686092, 19433865

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
93 GO:0034645 cellular macromolecule biosynthetic process
93 GO:0034654 nucleobase-containing compound biosynthetic process
93 GO:0019538 protein metabolic process
93 GO:0051252 regulation of RNA metabolic process
93 GO:0010468 regulation of gene expression
477 GO:0044271 cellular nitrogen compound biosynthetic process
477 GO:0090304 nucleic acid metabolic process
477 GO:1901362 organic cyclic compound biosynthetic process
477 GO:2000112 regulation of cellular macromolecule biosynthetic process
477 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
93 GO:0005829 cytosol
93 GO:0005634 nucleus
477 GO:0005829 cytosol
477 GO:0070013 intracellular organelle lumen
477 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0007049 cell cycle IEA
GO:0007165 signal transduction TAS
GO:0008283 cell proliferation IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IC
GO:0010008 endosome membrane IDA
GO:0016581 NuRD complex IDA
GO:0031901 early endosome membrane IEA
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
PMID Article Title
11431708 Disruption of the ProSAP2 gene in a t(12;22)(q24.1;q13.3) is associated with the 22q13.3 deletion syndrome.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15016378 APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075 The finished DNA sequence of human chromosome 12.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
No results found.
Domain Name Domain ID Source
PH_domain IPR001849 InterPro
PTB/PI_dom IPR006020 InterPro
PH-like_dom_sf IPR011993 InterPro
AH/BAR_dom_sf IPR027267 InterPro
PH PF00169 Pfam
PID PF00640 Pfam
PID PS01179 PROSITE
PH_DOMAIN PS50003 PROSITE
PH SM00233 SMART
PTB SM00462 SMART
SSF103657 SSF103657 SUPFAM