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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q93062
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q93062 (Uniprot)
RBPMS_HUMAN
RBPMS
RNA-binding protein with multiple splicing
human
No
Protein Function
Uniprot:
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the n
uclear accumulation of SMAD2, SMAD3 and SMAD4 proteins (PubMed:26347403). Binds to poly(A) RNA (PubMed:17099224, PubMed:26347403).
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MoonDB Dissimilar Functions
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GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0036211
protein modification process
26
GO:0006396
RNA processing
426
5.60e-03
3.14e-16
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 41 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
26
GO:0006464
cellular protein modification process
26
GO:0090304
nucleic acid metabolic process
26
GO:0010468
regulation of gene expression
64
GO:0016070
RNA metabolic process
64
GO:0010467
gene expression
64
GO:0060255
regulation of macromolecule metabolic process
67
GO:0060255
regulation of macromolecule metabolic process
153
GO:0090304
nucleic acid metabolic process
153
GO:0060255
regulation of macromolecule metabolic process
351
GO:0022402
cell cycle process
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Cellular Components
Showing 1 to 10 of 23 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
26
GO:0005654
nucleoplasm
60
GO:0005634
nucleus
64
GO:0005634
nucleus
67
GO:0005634
nucleus
153
GO:0005634
nucleus
271
GO:0005634
nucleus
351
GO:0043232
intracellular non-membrane-bounded organelle
351
GO:0005654
nucleoplasm
402
GO:0005829
cytosol
403
GO:0005634
nucleus
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Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0000398
mRNA splicing, via spliceosome
IBA
GO:0006351
transcription, DNA-templated
IEA
GO:0006355
regulation of transcription, DNA-templated
IEA
GO:0006396
RNA processing
TAS
GO:0006979
response to oxidative stress
IMP
GO:0010862
positive regulation of pathway-restricted SMAD protein phosphorylation
IDA
GO:0060391
positive regulation of SMAD protein import into nucleus
IDA
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Cellular Components
Showing 1 to 5 of 5 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000932
P-body
IEA
GO:0005654
nucleoplasm
IDA
GO:0005685
U1 snRNP
IBA
GO:0005829
cytosol
IDA
GO:0010494
cytoplasmic stress granule
IDA
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 259 entries
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Interactor
Also a MoonDB EMF protein
6PGL_HUMAN
No
A0A024R0L9_HUMAN
No
A0A024R5S0_HUMAN
No
A0A024R857_HUMAN
No
A0A0C4DGF1_HUMAN
No
A1L4F5_HUMAN
No
A8KA13_HUMAN
No
AAKB2_HUMAN
No
AAPK1_HUMAN
No
AAPK2_HUMAN
No
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Publications Associated
Showing 1 to 7 of 7 entries
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PMID
Article Title
8855282
A unique human gene that spans over 230 kb in the human chromosome 8p11-12 and codes multiple family proteins sharing RNA-binding motifs.
14759258
An unappreciated role for RNA surveillance.
15489334
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17099224
Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS.
18669648
A quantitative atlas of mitotic phosphorylation.
22814378
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
26347403
Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 7 of 7 entries
Search:
Domain Name
Domain ID
Source
JC6127
JC6127
PIR
RBD_domain_sf
IPR035979
InterPro
RRM
PS50102
PROSITE
RRM
SM00360
SMART
RRM_1
PF00076
Pfam
RRM_dom
IPR000504
InterPro
SSF54928
SSF54928
SUPFAM
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