Protein: Q13492 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q13492 (Uniprot)	PICAL_HUMAN	PICALM	Phosphatidylinositol-binding clathrin assembly protein	human	Yes

Protein Function

Uniprot: Assembly protein recruiting clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. Involved in AP2-dependent clathrin-me more..

Dissimilar Functions Manual Curation

Function 1: Endocytic function. Assembly protein recruiting clathrin and AP2 to cell membranes.

Function 2: Activation of transcription in Gal4 assay via its TAD domain. Condition: nuclear localisation (nuclear import via interaction with CATS transcription factor, export via interaction with CRM1).

Publications (PMID): 16491119, 11425879

MoonDB Network Modules

Biological Processes

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
60	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006461	protein complex assembly	TAS
GO:0006898	receptor-mediated endocytosis	IDA
GO:0007409	axonogenesis	IEA
GO:0007611	learning or memory	ISS
GO:0008283	cell proliferation	IMP
GO:0010629	negative regulation of gene expression	IMP
GO:0016050	vesicle organization	IMP
GO:0016188	synaptic vesicle maturation	ISS
GO:0016192	vesicle-mediated transport	TAS
GO:0016197	endosomal transport	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005769	early endosome	IDA
GO:0005794	Golgi apparatus	IEA
GO:0005829	cytosol	TAS
GO:0005905	clathrin-coated pit	IMP
GO:0009986	cell surface	IDA
GO:0016020	membrane	IDA
GO:0030122	AP-2 adaptor complex	IDA
GO:0030132	clathrin coat of coated pit	IDA
GO:0030136	clathrin-coated vesicle	IMP

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0005794	Golgi apparatus	4.39e-25	2.14e-64
GO:0005634	nucleus	GO:0009986	cell surface	1.10e-44	1.49e-81
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0030136	clathrin-coated vesicle	6.14e-04	7.94e-24
GO:0005634	nucleus	GO:0031224	intrinsic component of membrane	0.00e+00	0.00e+00
GO:0005634	nucleus	GO:0031982	vesicle	1.94e-54	3.27e-93
GO:0005634	nucleus	GO:0045211	postsynaptic membrane	4.18e-05	1.09e-18
GO:0005634	nucleus	GO:0045334	clathrin-coated endocytic vesicle	6.29e-03	1.54e-23
GO:0005829	cytosol	GO:0009986	cell surface	3.26e-22	6.81e-06
GO:0005829	cytosol	GO:0031224	intrinsic component of membrane	0.00e+00	0.00e+00

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ATX1_HUMAN	Yes: P54253 (MoonDB)
CRX_HUMAN	No
ITSN1_HUMAN	No
PELI2_HUMAN	No
RBPMS_HUMAN	Yes: Q93062 (MoonDB)
ZC3HA_HUMAN	No

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Publications Associated

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PMID	Article Title
8643484	The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
9737689	Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.
10436022	Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16491119	The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.
16554811	Human chromosome 11 DNA sequence and analysis including novel gene identification.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

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OMIM Diseases Associated

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Protein Domains Associated

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Domain Name	Domain ID	Source
ANTH	PF07651	Pfam
ANTH_dom	IPR011417	InterPro
Clathrin_AP_dom2	IPR014712	InterPro
ENTH	IPR013809	InterPro
ENTH	PS50942	PROSITE
ENTH	SM00273	SMART
ENTH_VHS	IPR008942	InterPro
PICALM	IPR030412	InterPro
PTHR22951:SF16	PTHR22951:SF16	PANTHER
SSF48464	SSF48464	SUPFAM

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