Protein: A5D8V6

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
A5D8V6 (Uniprot) VP37C_HUMAN VPS37C Vacuolar protein sorting-associated protein 37C human No
Uniprot: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 153 GO:0007165 signal transduction 355 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
64 GO:0016070 RNA metabolic process
64 GO:0010467 gene expression
64 GO:0060255 regulation of macromolecule metabolic process
153 GO:0090304 nucleic acid metabolic process
153 GO:0060255 regulation of macromolecule metabolic process
191 GO:0006355 regulation of transcription, DNA-templated
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
403 GO:0060255 regulation of macromolecule metabolic process
450 GO:0051252 regulation of RNA metabolic process
450 GO:0010646 regulation of cell communication
450 GO:2000112 regulation of cellular macromolecule biosynthetic process
450 GO:0010468 regulation of gene expression
450 GO:0023051 regulation of signaling
450 GO:0007165 signal transduction
552 GO:0044267 cellular protein metabolic process
620 GO:0019538 protein metabolic process
620 GO:0006355 regulation of transcription, DNA-templated
620 GO:0006366 transcription from RNA polymerase II promoter
743 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
60 GO:0005634 nucleus
64 GO:0005634 nucleus
153 GO:0005634 nucleus
191 GO:0031981 nuclear lumen
298 GO:0015630 microtubule cytoskeleton
355 GO:0044459 plasma membrane part
403 GO:0005634 nucleus
450 GO:0005634 nucleus
552 GO:0005634 nucleus
620 GO:0031981 nuclear lumen
641 GO:0005634 nucleus
743 GO:0012505 endomembrane system
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0015031 protein transport IEA
GO:0016197 endosomal transport TAS
GO:0016236 macroautophagy TAS
GO:0019058 viral life cycle TAS
GO:0036258 multivesicular body assembly TAS
GO:0039702 viral budding via host ESCRT complex TAS
GO:0075733 intracellular transport of virus TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000813 ESCRT I complex IDA
GO:0010008 endosome membrane TAS
GO:0031902 late endosome membrane IEA
GO:0043657 host cell IEA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
Interactor Also a MoonDB EMF protein
RBPMS_HUMAN Yes: Q93062 (MoonDB)
TFP11_HUMAN No
PSA3_HUMAN Yes: P25788 (MoonDB)
HNRPF_HUMAN No
PR20D_HUMAN No
DAZP2_HUMAN Yes: Q15038 (MoonDB)
KR195_HUMAN No
CRX_HUMAN No
VINEX_HUMAN No
PROP1_HUMAN No
PKNX2_HUMAN No
A0A087WSW0_HUMAN No
AARD_HUMAN No
ABHDB_HUMAN No
AES_HUMAN Yes: Q08117 (MoonDB)
AP2D_HUMAN No
ASCL3_HUMAN No
BAAS2_HUMAN No
BAG4_HUMAN No
BIRC7_HUMAN No
CA094_HUMAN No
CEP55_HUMAN No
DCTN3_HUMAN No
DDIT3_HUMAN No
DYDC1_HUMAN No
EYA2_HUMAN No
F168A_HUMAN No
F168B_HUMAN No
FCSD2_HUMAN No
FOXI1_HUMAN No
FUBP1_HUMAN No
G4XUV3_HUMAN No
GOGA2_HUMAN Yes: Q08379 (MoonDB)
GPS2_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
HAUS1_HUMAN No
HGS_HUMAN No
HNRL1_HUMAN No
ILF3_HUMAN No
K1C27_HUMAN No
KR151_HUMAN No
KR196_HUMAN No
KRA62_HUMAN No
KT33B_HUMAN No
LAGE3_HUMAN No
LASP1_HUMAN No
MET27_HUMAN No
MISSL_HUMAN No
NTAQ1_HUMAN Yes: Q96HA8 (MoonDB)
NTM2F_HUMAN No
NUP54_HUMAN No
OBF1_HUMAN No
P4HA3_HUMAN No
PA2GX_HUMAN No
PARP2_HUMAN No
PAX9_HUMAN No
PDC6I_HUMAN Yes: Q8WUM4 (MoonDB)
PDCD6_HUMAN No
PEF1_HUMAN No
PKHG4_HUMAN No
PKNX1_HUMAN No
PLS1_HUMAN No
Q6ZP95_HUMAN No
RAM_HUMAN No
RBPS2_HUMAN No
RFX6_HUMAN No
RIBC1_HUMAN No
RINT1_HUMAN No
RPB11_HUMAN No
RPB1C_HUMAN No
RPR1B_HUMAN No
RUNX1_HUMAN No
SH3G1_HUMAN No
SH3R2_HUMAN No
SPAG8_HUMAN No
SRBS2_HUMAN No
STAM2_HUMAN No
STH_HUMAN No
TACC3_HUMAN No
TFG_HUMAN Yes: Q92734 (MoonDB)
TIAR_HUMAN No
TS101_HUMAN Yes: Q99816 (MoonDB)
TSC1_HUMAN No
U2D2L_HUMAN No
UFSP1_HUMAN No
WHAL1_HUMAN No
WWOX_HUMAN No
WWP2_HUMAN Yes: O00308 (MoonDB)
XIAP_HUMAN Yes: P98170 (MoonDB)
YTHD1_HUMAN No
ZMY12_HUMAN No
PMID Article Title
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15509564 Identification of human VPS37C, a component of endosomal sorting complex required for transport-I important for viral budding.
16554811 Human chromosome 11 DNA sequence and analysis including novel gene identification.
17853893 Human ESCRT and ALIX proteins interact with proteins of the midbody and function in cytokinesis.
17974005 The full-ORF clone resource of the German cDNA consortium.
18005716 Identification of human MVB12 proteins as ESCRT-I subunits that function in HIV budding.
21269460 Initial characterization of the human central proteome.
21270402 TANK-binding kinase 1 attenuates PTAP-dependent retroviral budding through targeting endosomal sorting complex required for transport-I.
22405001 The UBAP1 subunit of ESCRT-I interacts with ubiquitin via a SOUBA domain.
No results found.
Domain Name Domain ID Source
Mod_r IPR009851 InterPro
HLH_DNA-bd_sf IPR036638 InterPro
ESCRT_assembly_dom IPR037202 InterPro
Mod_r PF07200 Pfam
VPS37_C PS51314 PROSITE
SSF140111 SSF140111 SUPFAM