Protein: Q99816 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q99816 (Uniprot)	TS101_HUMAN	TSG101	Tumor susceptibility gene 101 protein	human	Yes

Protein Function

Uniprot: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cy more..

Dissimilar Functions Manual Curation

Function 1: Transport, part of the ESCRT complex (endocytosis). Condition: mainly cytoplasmic, membrane-associated when active and soluble when inactive.

Function 2: Transcriptional repressor protein, decreasing GR-dependent transcriptional activation by binding and repressing AF-1. Condition: nuclear localisation (cell cycle dependant, nuclear localisation increased through binding of nuclear proteins AATF, Daxx or RTA).

Publications (PMID): 10508170, 9588212, 9465061, 17182691

MoonDB Dissimilar Functions

Showing 1 to 2 of 2 entries

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	255	GO:0006139	nucleobase-containing compound metabolic process	713	1.10e-111	5.07e-25
GO:0009056	catabolic process	48, 125	GO:0009059	macromolecule biosynthetic process	672	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Search:

Module ID (MoonGO)	GO ID (BP)	GO Name
48	GO:0044248	cellular catabolic process
48	GO:0070647	protein modification by small protein conjugation or removal
48	GO:0006508	proteolysis
48	GO:0060255	regulation of macromolecule metabolic process
48	GO:0007165	signal transduction
67	GO:0060255	regulation of macromolecule metabolic process
116	GO:0019538	protein metabolic process
116	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
48	GO:0031410	cytoplasmic vesicle
48	GO:0012505	endomembrane system
48	GO:0005634	nucleus
48	GO:0005886	plasma membrane
67	GO:0005634	nucleus
116	GO:0005829	cytosol
116	GO:0070013	intracellular organelle lumen
116	GO:0005634	nucleus
125	GO:0005829	cytosol
125	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001558	regulation of cell growth	IEA
GO:0006513	protein monoubiquitination	IEA
GO:0006858	extracellular transport	IMP
GO:0007050	cell cycle arrest	IEA
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity	IMP
GO:0008285	negative regulation of cell proliferation	IEA
GO:0008333	endosome to lysosome transport	IEA
GO:0015031	protein transport	IEA
GO:0016197	endosomal transport	TAS
GO:0016236	macroautophagy	TAS

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Cellular Components

Showing 1 to 10 of 16 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000813	ESCRT I complex	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005768	endosome	IDA
GO:0005769	early endosome	IDA
GO:0005770	late endosome	IMP
GO:0005771	multivesicular body	TAS
GO:0005815	microtubule organizing center	IEA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005730	nucleolus	GO:0005886	plasma membrane	7.70e-47	3.09e-07
GO:0005815	microtubule organizing center	GO:0005886	plasma membrane	3.20e-06	1.55e-21

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All Protein Interactions

Showing 1 to 10 of 124 entries

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Interactor	Also a MoonDB EMF protein
ABCB6_HUMAN	No
ACAD8_HUMAN	No
ADRB2_HUMAN	Yes: P07550 (MoonDB)
AJUBA_HUMAN	No
AKAP9_HUMAN	No
ALG2_HUMAN	No
AMPL_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ARRD1_HUMAN	No
ASPP1_HUMAN	No

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Publications Associated

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PMID	Article Title
9019400	The TSG101 tumor susceptibility gene is located in chromosome 11 band p15 and is mutated in human breast cancer.
9242438	Aberrant splicing but not mutations of TSG101 in human breast cancer.
9366528	Aberrant splicing of the TSG101 and FHIT genes occurs frequently in multiple malignancies and in normal tissues and mimics alterations previously described in tumours.
9840940	Genomic architecture and transcriptional activation of the mouse and human tumor susceptibility gene TSG101: common types of shorter transcripts are true alternative splice variants.
10888872	DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci.
11427703	Tsg101, a homologue of ubiquitin-conjugating (E2) enzymes, binds the L domain in HIV type 1 Pr55(Gag).
11595185	Tsg101 and the vacuolar protein sorting pathway are essential for HIV-1 budding.
11916981	Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates.
12006492	Structure and functional interactions of the Tsg101 UEV domain.
12379843	Structure of the Tsg101 UEV domain in complex with the PTAP motif of the HIV-1 p6 protein.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
ESCRT_assembly_dom	IPR037202	InterPro
SB	PS51312	PROSITE
SB_dom	IPR017916	InterPro
SSF140111	SSF140111	SUPFAM
SSF54495	SSF54495	SUPFAM
UBQ-conjugating_enzyme/RWD	IPR016135	InterPro
UEV	PF05743	Pfam
UEV	PS51322	PROSITE
UEV_N	IPR008883	InterPro
Vps23_core	PF09454	Pfam

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