Protein: P80188

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P80188 (Uniprot) NGAL_HUMAN LCN2 Neutrophil gelatinase-associated lipocalin human No
Uniprot: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0036211 protein modification process 199, 394 GO:0016070 RNA metabolic process 719 5.81e-04 8.44e-05
Module ID (MoonGO) GO ID (BP) GO Name
199 GO:0006464 cellular protein modification process
199 GO:0060255 regulation of macromolecule metabolic process
199 GO:0007165 signal transduction
218 GO:0060255 regulation of macromolecule metabolic process
343 GO:0060255 regulation of macromolecule metabolic process
394 GO:0006464 cellular protein modification process
394 GO:0031325 positive regulation of cellular metabolic process
394 GO:0010604 positive regulation of macromolecule metabolic process
394 GO:0051173 positive regulation of nitrogen compound metabolic process
394 GO:0032268 regulation of cellular protein metabolic process
394 GO:0006355 regulation of transcription, DNA-templated
394 GO:0007165 signal transduction
537 GO:0060255 regulation of macromolecule metabolic process
537 GO:0007165 signal transduction
632 GO:0010467 gene expression
632 GO:0090304 nucleic acid metabolic process
632 GO:0060255 regulation of macromolecule metabolic process
632 GO:0007165 signal transduction
719 GO:0006401 RNA catabolic process
719 GO:0016071 mRNA metabolic process
719 GO:0010629 negative regulation of gene expression
719 GO:0019219 regulation of nucleobase-containing compound metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
91 GO:0005576 extracellular region
199 GO:0012505 endomembrane system
199 GO:0005576 extracellular region
199 GO:0070013 intracellular organelle lumen
218 GO:0005634 nucleus
343 GO:0005634 nucleus
394 GO:0005654 nucleoplasm
523 GO:0005829 cytosol
523 GO:0031982 vesicle
537 GO:0012505 endomembrane system
628 GO:0005829 cytosol
628 GO:0070062 extracellular exosome
628 GO:0005634 nucleus
632 GO:0031981 nuclear lumen
719 GO:0005829 cytosol
719 GO:0043232 intracellular non-membrane-bounded organelle
719 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006811 ion transport IEA
GO:0006879 cellular iron ion homeostasis TAS
GO:0009615 response to virus IEA
GO:0009635 response to herbicide IEA
GO:0010046 response to mycotoxin IEA
GO:0010628 positive regulation of gene expression IEA
GO:0015891 siderophore transport ISS
GO:0019730 antimicrobial humoral response TAS
GO:0031346 positive regulation of cell projection organization IEA
GO:0031669 cellular response to nutrient levels IEA
GO:0042493 response to drug IEA
GO:0043312 neutrophil degranulation TAS
GO:0045087 innate immune response ISS
GO:0070207 protein homotrimerization IEA
GO:0070301 cellular response to hydrogen peroxide IEA
GO:0071222 cellular response to lipopolysaccharide IEA
GO:0071347 cellular response to interleukin-1 IEA
GO:0071356 cellular response to tumor necrosis factor IEA
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005615 extracellular space IDA
GO:0005829 cytosol IEA
GO:0035580 specific granule lumen TAS
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1281792 A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase.
7683678 Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase.
7835423 Cloning and expression of human neutrophil lipocalin cDNA derived from bone marrow and ovarian cancer cells.
8060329 Molecular cloning and expression of a cDNA encoding NGAL: a lipocalin expressed in human neutrophils.
9339356 Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans.
10339412 The solution structure and dynamics of human neutrophil gelatinase-associated lipocalin.
10684642 Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.
12453412 The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition.
12453413 An iron delivery pathway mediated by a lipocalin.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15084671 A proteomic analysis of human bile.
15164053 DNA sequence and analysis of human chromosome 9.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16335952 Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
16740002 Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry.
19159218 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
19229297 Transcription and signalling pathways involved in BCR-ABL-mediated misregulation of 24p3 and 24p3R.
21269460 Initial characterization of the human central proteome.
No results found.
Domain Name Domain ID Source
Lipocln_cytosolic_FA-bd_dom IPR000566 InterPro
Lipocalin IPR002345 InterPro
LCN2/LCN12 IPR003087 InterPro
Calycin IPR012674 InterPro
Lipocalin_CS IPR022272 InterPro
JC2339 JC2339 PIR
Lipocalin PF00061 Pfam
SSF50814 SSF50814 SUPFAM