Protein: O75674 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
O75674 (Uniprot)	TM1L1_HUMAN	TOM1L1	TOM1-like protein 1	human	No

Protein Function

Uniprot: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0043170	macromolecule metabolic process	531	GO:0051641	cellular localization	872	4.90e-06	1.31e-91

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
37	GO:0007165	signal transduction
134	GO:0044267	cellular protein metabolic process
134	GO:0060255	regulation of macromolecule metabolic process
134	GO:0007165	signal transduction
145	GO:0060255	regulation of macromolecule metabolic process
166	GO:0044267	cellular protein metabolic process
166	GO:0006139	nucleobase-containing compound metabolic process
166	GO:0060255	regulation of macromolecule metabolic process
166	GO:0007165	signal transduction
181	GO:0044267	cellular protein metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
37	GO:0005829	cytosol
134	GO:0005829	cytosol
134	GO:0005634	nucleus
140	GO:0043232	intracellular non-membrane-bounded organelle
145	GO:0070013	intracellular organelle lumen
145	GO:0044428	nuclear part
166	GO:0005829	cytosol
166	GO:0070013	intracellular organelle lumen
166	GO:0044428	nuclear part
166	GO:0005886	plasma membrane

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006886	intracellular protein transport	IEA
GO:0007165	signal transduction	IDA
GO:0031954	positive regulation of protein autophosphorylation	IDA
GO:0032147	activation of protein kinase activity	IDA
GO:0043162	ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS
GO:0045839	negative regulation of mitotic nuclear division	IDA
GO:2000278	regulation of DNA biosynthetic process	IDA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IDA
GO:0005764	lysosome	TAS
GO:0005768	endosome	IDA
GO:0005795	Golgi stack	IEA
GO:0005829	cytosol	IDA
GO:0010008	endosome membrane	IEA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AMFR_HUMAN	No
B4DWU0_HUMAN	No
C19L1_HUMAN	No
CCD47_HUMAN	No
CELF1_HUMAN	No
CSN7A_HUMAN	No
DHE4_HUMAN	No
DJB13_HUMAN	No
GELS_HUMAN	No
HGS_HUMAN	No

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Publications Associated

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PMID	Article Title
10329004	TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16625196	DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17525332	ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
18669648	A quantitative atlas of mitotic phosphorylation.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332	Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231	Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
23186163	Toward a comprehensive characterization of a human cancer cell phosphoproteome.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
ENTH_VHS	IPR008942	InterPro
GAT	PF03127	Pfam
GAT	PS50909	PROSITE
GAT_dom	IPR004152	InterPro
PTHR13856:SF28	PTHR13856:SF28	PANTHER
SSF48464	SSF48464	SUPFAM
TOM1	IPR014645	InterPro
TOM1	PIRSF036948	PIRSF
TOM1L1	IPR027428	InterPro
VHS	PF00790	Pfam

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