Protein: P52735 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P52735 (Uniprot)	VAV2_HUMAN	VAV2	Guanine nucleotide exchange factor VAV2	human	No

Protein Function

Uniprot: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	166, 181, 215, 376	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	467	1.88e-02	4.66e-37

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
37	GO:0007165	signal transduction
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation
111	GO:0060255	regulation of macromolecule metabolic process
111	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
166	GO:0044267	cellular protein metabolic process
166	GO:0006139	nucleobase-containing compound metabolic process
166	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
37	GO:0005829	cytosol
43	GO:0005634	nucleus
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
166	GO:0005829	cytosol
166	GO:0070013	intracellular organelle lumen
166	GO:0044428	nuclear part
166	GO:0005886	plasma membrane
167	GO:0005654	nucleoplasm
181	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0001525	angiogenesis	IEA
GO:0007165	signal transduction	TAS
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0007264	small GTPase mediated signal transduction	IEA
GO:0008361	regulation of cell size	IGI
GO:0010468	regulation of gene expression	IMP
GO:0016477	cell migration	IEA
GO:0030032	lamellipodium assembly	IEA
GO:0030168	platelet activation	TAS
GO:0030193	regulation of blood coagulation	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
3BP2_HUMAN	No
ANDR_HUMAN	Yes: P10275 (MoonDB)
ARI1_HUMAN	No
BD1L1_HUMAN	No
BIRC6_HUMAN	No
BRDT_HUMAN	No
BZW1_HUMAN	No
CBLB_HUMAN	No
CCNO_HUMAN	No
CE170_HUMAN	No

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Publications Associated

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PMID	Article Title
7762982	Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.
12454019	Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.
15164053	DNA sequence and analysis of human chromosome 9.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15561106	The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
15618286	Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
16964243	A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17974005	The full-ORF clone resource of the German cDNA consortium.
18669648	A quantitative atlas of mitotic phosphorylation.
18691976	Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
C1	SM00109	SMART
C1	cd00029	CDD
C1_1	PF00130	Pfam
Calponin-like_dom_sf	IPR036872	InterPro
CAMSAP_CH	IPR022613	InterPro
CAMSAP_CH	PF11971	Pfam
CH	PS50021	PROSITE
CH	SM00033	SMART
CH	cd00014	CDD
CH-domain	IPR001715	InterPro

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