Protein: P07550

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P07550 (Uniprot) ADRB2_HUMAN ADRB2 Beta-2 adrenergic receptor human No
Uniprot: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 187 GO:0006725 cellular aromatic compound metabolic process 222 5.44e-126 5.27e-27
GO:0009059 macromolecule biosynthetic process 401 GO:0009056 catabolic process 48 6.37e-04 1.88e-40
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
48 GO:0044248 cellular catabolic process
48 GO:0070647 protein modification by small protein conjugation or removal
48 GO:0006508 proteolysis
48 GO:0060255 regulation of macromolecule metabolic process
48 GO:0007165 signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
274 GO:0007165 signal transduction
401 GO:0034645 cellular macromolecule biosynthetic process
401 GO:0060255 regulation of macromolecule metabolic process
828 GO:0007166 cell surface receptor signaling pathway
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
48 GO:0031410 cytoplasmic vesicle
48 GO:0012505 endomembrane system
48 GO:0005634 nucleus
48 GO:0005886 plasma membrane
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
401 GO:0005634 nucleus
501 GO:0031090 organelle membrane
828 GO:0016021 integral component of membrane
828 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002024 diet induced thermogenesis IEA
GO:0002025 norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IBA
GO:0002028 regulation of sodium ion transport IEA
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin IDA
GO:0006898 receptor-mediated endocytosis IDA
GO:0007166 cell surface receptor signaling pathway TAS
GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity TAS
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway TAS
GO:0007190 activation of adenylate cyclase activity IDA
GO:0007267 cell-cell signaling IBA
GO:0008333 endosome to lysosome transport TAS
GO:0009409 response to cold IEA
GO:0010739 positive regulation of protein kinase A signaling IGI
GO:0016579 protein deubiquitination TAS
GO:0030501 positive regulation of bone mineralization IEA
GO:0031398 positive regulation of protein ubiquitination IMP
GO:0031649 heat generation IEA
GO:0040015 negative regulation of multicellular organism growth IEA
GO:0043410 positive regulation of MAPK cascade IDA
GO:0045453 bone resorption IEA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:0045986 negative regulation of smooth muscle contraction IBA
GO:0050873 brown fat cell differentiation IEA
GO:0061024 membrane organization TAS
GO:0061885 positive regulation of mini excitatory postsynaptic potential IEA
GO:0071875 adrenergic receptor signaling pathway IDA
GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway IBA
GO:0071902 positive regulation of protein serine/threonine kinase activity IGI
GO:1901098 positive regulation of autophagosome maturation IDA
GO:1904504 positive regulation of lipophagy IDA
GO:1904646 cellular response to amyloid-beta IGI
GO:1990911 response to psychosocial stress TAS
GO:2000481 positive regulation of cAMP-dependent protein kinase activity TAS
GO:2000969 positive regulation of AMPA receptor activity IGI
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IEA
GO:0005764 lysosome TAS
GO:0005768 endosome TAS
GO:0005769 early endosome IEA
GO:0005886 plasma membrane TAS
GO:0005887 integral component of plasma membrane IDA
GO:0010008 endosome membrane TAS
GO:0016020 membrane NAS
GO:0016324 apical plasma membrane IEA
GO:0030665 clathrin-coated vesicle membrane TAS
GO:0043235 receptor complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005764 lysosome 5.88e-10 1.00e-16
GO:0005634 nucleus GO:0005768 endosome 4.09e-12 7.34e-15
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005634 nucleus GO:0005887 integral component of plasma membrane 6.41e-134 1.88e-259
GO:0005634 nucleus GO:0010008 endosome membrane 1.38e-08 8.40e-30
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0016324 apical plasma membrane 8.24e-09 4.92e-02
GO:0005634 nucleus GO:0030665 clathrin-coated vesicle membrane 3.06e-05 6.65e-11
PMID Article Title
2540197 Palmitoylation of the human beta 2-adrenergic receptor. Mutation of Cys341 in the carboxyl tail leads to an uncoupled nonpalmitoylated form of the receptor.
2823249 Structure of the gene for human beta 2-adrenergic receptor: expression and promoter characterization.
2831218 Site-directed mutagenesis and continuous expression of human beta-adrenergic receptors. Identification of a conserved aspartate residue involved in agonist binding and receptor activation.
3025863 cDNA for the human beta 2-adrenergic receptor: a protein with multiple membrane-spanning domains and encoded by a gene whose chromosomal location is shared with that of the receptor for platelet-derived growth factor.
3026848 Cloning and sequence analysis of the human brain beta-adrenergic receptor. Evolutionary relationship to rodent and avian beta-receptors and porcine muscarinic receptors.
3033609 Primary structure of the human beta-adrenergic receptor gene.
3034889 Delineation of the intronless nature of the genes for the human and hamster beta 2-adrenergic receptor and their putative promoter regions.
7706471 Genetic polymorphisms of the beta 2-adrenergic receptor in nocturnal and nonnocturnal asthma. Evidence that Gly16 correlates with the nocturnal phenotype.
7822302 Arrestin interactions with G protein-coupled receptors. Direct binding studies of wild type and mutant arrestins with rhodopsin, beta 2-adrenergic, and m2 muscarinic cholinergic receptors.
7915137 Amino-terminal polymorphisms of the human beta 2-adrenergic receptor impart distinct agonist-promoted regulatory properties.
8383511 Mutations in the gene encoding for the beta 2-adrenergic receptor in normal and asthmatic subjects.
8521811 Mutation of tyrosine-141 inhibits insulin-promoted tyrosine phosphorylation and increased responsiveness of the human beta 2-adrenergic receptor.
9388255 Clathrin-mediated endocytosis of the beta-adrenergic receptor is regulated by phosphorylation/dephosphorylation of beta-arrestin1.
9924018 Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.
10499588 A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor.
11146000 The palmitoylation state of the beta(2)-adrenergic receptor regulates the synergistic action of cyclic AMP-dependent protein kinase and beta-adrenergic receptor kinase involved in its phosphorylation and desensitization.
11246467 Beta2-adrenergic receptor allele frequencies in the Quechua, a high altitude native population.
12142540 Modulation of postendocytic sorting of G protein-coupled receptors.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17952055 Crystal structure of the human beta2 adrenergic G-protein-coupled receptor.
17962520 High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor.
18547522 A specific cholesterol binding site is established by the 2.8 A structure of the human beta2-adrenergic receptor.
19424180 The deubiquitinases USP33 and USP20 coordinate beta2 adrenergic receptor recycling and resensitization.
19584355 Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
20559325 Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the beta2-adrenergic receptor.
20733053 SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.
21602791 SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.
24405750 CNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulum.
25220262 Insights into beta2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.
No results found.
Domain Name Domain ID Source
QRHUB2 A27525 PIR
GPCR_Rhodpsn IPR000276 InterPro
ADRB2_rcpt IPR000332 InterPro
ADR_fam IPR002233 InterPro
GPCR_Rhodpsn_7TM IPR017452 InterPro
7tm_1 PF00001 Pfam
GPCRRHODOPSN PR00237 PRINTS
ADRENRGCB2AR PR00562 PRINTS
ADRENERGICR PR01103 PRINTS
G_PROTEIN_RECEP_F1_1 PS00237 PROSITE
G_PROTEIN_RECEP_F1_2 PS50262 PROSITE
PTHR24248:SF21 PTHR24248:SF21 PANTHER
7TM_GPCR_Srsx SM01381 SMART
7tmA_Beta2_AR cd15957 CDD