Protein: P40763

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P40763 (Uniprot) STAT3_HUMAN STAT3 Signal transducer and activator of transcription 3 human No
Uniprot: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 35 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 810 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0006725 cellular aromatic compound metabolic process 222, 736 3.09e-47 2.24e-87
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 804 6.88e-41 1.21e-84
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 35, 810 4.22e-144 6.90e-18
GO:0007165 signal transduction 187 GO:0006725 cellular aromatic compound metabolic process 222, 736 5.44e-126 5.27e-27
GO:0007165 signal transduction 187 GO:0006139 nucleobase-containing compound metabolic process 804 1.10e-111 5.07e-25
GO:0006725 cellular aromatic compound metabolic process 222 GO:0006928 movement of cell or subcellular component 496 1.24e-32 2.63e-196
GO:0006928 movement of cell or subcellular component 496 GO:0006139 nucleobase-containing compound metabolic process 804 1.95e-31 6.36e-195
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
10 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
120 GO:0006464 cellular protein modification process
120 GO:0070887 cellular response to chemical stimulus
120 GO:0031324 negative regulation of cellular metabolic process
120 GO:0010605 negative regulation of macromolecule metabolic process
120 GO:0051172 negative regulation of nitrogen compound metabolic process
120 GO:0031325 positive regulation of cellular metabolic process
120 GO:0010604 positive regulation of macromolecule metabolic process
120 GO:0051173 positive regulation of nitrogen compound metabolic process
120 GO:0006355 regulation of transcription, DNA-templated
120 GO:0007165 signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
222 GO:0006139 nucleobase-containing compound metabolic process
222 GO:0060255 regulation of macromolecule metabolic process
222 GO:0007165 signal transduction
287 GO:0006464 cellular protein modification process
287 GO:0006355 regulation of transcription, DNA-templated
303 GO:0007165 signal transduction
377 GO:0007165 signal transduction
413 GO:0044267 cellular protein metabolic process
413 GO:0031326 regulation of cellular biosynthetic process
413 GO:0010468 regulation of gene expression
413 GO:0010556 regulation of macromolecule biosynthetic process
413 GO:0007165 signal transduction
413 GO:0006351 transcription, DNA-templated
428 GO:0044267 cellular protein metabolic process
428 GO:0090304 nucleic acid metabolic process
428 GO:0060255 regulation of macromolecule metabolic process
435 GO:0031325 positive regulation of cellular metabolic process
435 GO:0010604 positive regulation of macromolecule metabolic process
435 GO:0051173 positive regulation of nitrogen compound metabolic process
435 GO:0019538 protein metabolic process
435 GO:0006357 regulation of transcription from RNA polymerase II promoter
435 GO:0007165 signal transduction
469 GO:0060255 regulation of macromolecule metabolic process
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
499 GO:0006464 cellular protein modification process
499 GO:0060255 regulation of macromolecule metabolic process
514 GO:0044267 cellular protein metabolic process
514 GO:0071310 cellular response to organic substance
514 GO:0033554 cellular response to stress
514 GO:0035556 intracellular signal transduction
514 GO:0031328 positive regulation of cellular biosynthetic process
514 GO:0010557 positive regulation of macromolecule biosynthetic process
514 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
514 GO:0042981 regulation of apoptotic process
514 GO:0010646 regulation of cell communication
514 GO:0023051 regulation of signaling
514 GO:0006357 regulation of transcription from RNA polymerase II promoter
591 GO:0016070 RNA metabolic process
591 GO:0010467 gene expression
591 GO:0060255 regulation of macromolecule metabolic process
617 GO:0007165 signal transduction
618 GO:0016070 RNA metabolic process
618 GO:0044271 cellular nitrogen compound biosynthetic process
618 GO:0006464 cellular protein modification process
618 GO:0070887 cellular response to chemical stimulus
618 GO:0006955 immune response
618 GO:0035556 intracellular signal transduction
618 GO:0031328 positive regulation of cellular biosynthetic process
618 GO:0010628 positive regulation of gene expression
618 GO:0002684 positive regulation of immune system process
618 GO:0010557 positive regulation of macromolecule biosynthetic process
618 GO:0051173 positive regulation of nitrogen compound metabolic process
618 GO:0048584 positive regulation of response to stimulus
618 GO:0006508 proteolysis
618 GO:0042981 regulation of apoptotic process
618 GO:2000112 regulation of cellular macromolecule biosynthetic process
618 GO:0019219 regulation of nucleobase-containing compound metabolic process
655 GO:0006464 cellular protein modification process
655 GO:0071310 cellular response to organic substance
655 GO:0035556 intracellular signal transduction
655 GO:0031325 positive regulation of cellular metabolic process
655 GO:0010604 positive regulation of macromolecule metabolic process
655 GO:0051173 positive regulation of nitrogen compound metabolic process
655 GO:0032268 regulation of cellular protein metabolic process
655 GO:0009966 regulation of signal transduction
655 GO:0006355 regulation of transcription, DNA-templated
655 GO:0009719 response to endogenous stimulus
736 GO:0006139 nucleobase-containing compound metabolic process
736 GO:0060255 regulation of macromolecule metabolic process
757 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
804 GO:0034654 nucleobase-containing compound biosynthetic process
804 GO:0010468 regulation of gene expression
810 GO:0044271 cellular nitrogen compound biosynthetic process
810 GO:0006139 nucleobase-containing compound metabolic process
810 GO:2000112 regulation of cellular macromolecule biosynthetic process
810 GO:0010468 regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
120 GO:0005829 cytosol
120 GO:0043232 intracellular non-membrane-bounded organelle
120 GO:0005654 nucleoplasm
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
222 GO:0070013 intracellular organelle lumen
222 GO:0044428 nuclear part
256 GO:0043232 intracellular non-membrane-bounded organelle
256 GO:0005634 nucleus
287 GO:0005829 cytosol
287 GO:0043232 intracellular non-membrane-bounded organelle
287 GO:0031981 nuclear lumen
377 GO:0005634 nucleus
413 GO:0005654 nucleoplasm
428 GO:0043232 intracellular non-membrane-bounded organelle
428 GO:0031981 nuclear lumen
435 GO:0005654 nucleoplasm
469 GO:0043232 intracellular non-membrane-bounded organelle
469 GO:0005634 nucleus
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
499 GO:0005829 cytosol
499 GO:0031981 nuclear lumen
514 GO:0005654 nucleoplasm
591 GO:0031981 nuclear lumen
618 GO:0005829 cytosol
618 GO:0044421 extracellular region part
618 GO:0043232 intracellular non-membrane-bounded organelle
618 GO:0005654 nucleoplasm
618 GO:0005886 plasma membrane
618 GO:0031982 vesicle
651 GO:0005829 cytosol
655 GO:0005829 cytosol
655 GO:0005654 nucleoplasm
736 GO:0005829 cytosol
736 GO:0070013 intracellular organelle lumen
736 GO:0044428 nuclear part
757 GO:0070013 intracellular organelle lumen
757 GO:0005634 nucleus
804 GO:0005829 cytosol
804 GO:0005634 nucleus
810 GO:0044428 nuclear part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter TAS
GO:0001659 temperature homeostasis ISS
GO:0001754 eye photoreceptor cell differentiation ISS
GO:0006355 regulation of transcription, DNA-templated IDA
GO:0006357 regulation of transcription from RNA polymerase II promoter ISS
GO:0006606 protein import into nucleus IDA
GO:0006928 movement of cell or subcellular component TAS
GO:0006953 acute-phase response IEA
GO:0006954 inflammatory response ISS
GO:0007165 signal transduction TAS
GO:0007259 JAK-STAT cascade TAS
GO:0007399 nervous system development TAS
GO:0007568 aging IEA
GO:0008283 cell proliferation IEA
GO:0008285 negative regulation of cell proliferation IEA
GO:0010628 positive regulation of gene expression IMP
GO:0010730 negative regulation of hydrogen peroxide biosynthetic process IEA
GO:0016032 viral process IEA
GO:0016310 phosphorylation ISS
GO:0019221 cytokine-mediated signaling pathway NAS
GO:0019953 sexual reproduction ISS
GO:0030522 intracellular receptor signaling pathway IDA
GO:0032355 response to estradiol IDA
GO:0032870 cellular response to hormone stimulus IDA
GO:0033210 leptin-mediated signaling pathway IDA
GO:0035019 somatic stem cell population maintenance TAS
GO:0035278 miRNA mediated inhibition of translation IDA
GO:0035722 interleukin-12-mediated signaling pathway TAS
GO:0035723 interleukin-15-mediated signaling pathway TAS
GO:0038111 interleukin-7-mediated signaling pathway TAS
GO:0040014 regulation of multicellular organism growth IEA
GO:0042493 response to drug IEA
GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein TAS
GO:0042593 glucose homeostasis ISS
GO:0042755 eating behavior ISS
GO:0042789 mRNA transcription from RNA polymerase II promoter IEA
GO:0043066 negative regulation of apoptotic process IMP
GO:0044320 cellular response to leptin stimulus IDA
GO:0044321 response to leptin IDA
GO:0045471 response to ethanol IEA
GO:0045648 positive regulation of erythrocyte differentiation IMP
GO:0045747 positive regulation of Notch signaling pathway ISS
GO:0045766 positive regulation of angiogenesis IEA
GO:0045820 negative regulation of glycolytic process IEA
GO:0045893 positive regulation of transcription, DNA-templated IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IGI
GO:0046902 regulation of mitochondrial membrane permeability IEA
GO:0048708 astrocyte differentiation ISS
GO:0051726 regulation of cell cycle IDA
GO:0060019 radial glial cell differentiation ISS
GO:0060259 regulation of feeding behavior ISS
GO:0060396 growth hormone receptor signaling pathway IDA
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway IDA
GO:0070102 interleukin-6-mediated signaling pathway IDA
GO:0071407 cellular response to organic cyclic compound IEA
GO:0072540 T-helper 17 cell lineage commitment ISS
GO:0097009 energy homeostasis ISS
GO:1901215 negative regulation of neuron death IEA
GO:1902728 positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IEA
GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter IDA
GO:1904685 positive regulation of metalloendopeptidase activity IGI
GO:1905564 positive regulation of vascular endothelial cell proliferation IEA
GO:2000637 positive regulation of gene silencing by miRNA IDA
GO:2000737 negative regulation of stem cell differentiation IEA
GO:2001171 positive regulation of ATP biosynthetic process IEA
GO:2001223 negative regulation of neuron migration IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005743 mitochondrial inner membrane IEA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane ISS
GO:0090575 RNA polymerase II transcription factor complex IMP
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0005886 plasma membrane 1.05e-21 5.03e-79
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005654 nucleoplasm GO:0005743 mitochondrial inner membrane 5.37e-05 2.97e-03
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005743 mitochondrial inner membrane GO:0005829 cytosol 6.20e-17 9.93e-03
GO:0005886 plasma membrane GO:0090575 RNA polymerase II transcription factor complex 4.33e-11 1.61e-73
Interactor Also a MoonDB EMF protein
KR107_HUMAN No
FHL2_HUMAN No
RBTN2_HUMAN No
NUFP2_HUMAN No
NIF3L_HUMAN No
BLK_HUMAN No
P55G_HUMAN Yes: Q92569 (MoonDB)
3BP2_HUMAN No
LASP1_HUMAN No
COR1A_HUMAN No
ARFP2_HUMAN No
SIAH1_HUMAN Yes: Q8IUQ4 (MoonDB)
G45IP_HUMAN No
CE120_HUMAN Yes: Q8N960 (MoonDB)
EGFR_HUMAN Yes: P00533 (MoonDB)
ASXL1_HUMAN No
NXT2_HUMAN No
ERBB2_HUMAN Yes: P04626 (MoonDB)
F208B_HUMAN No
SOCS7_HUMAN No
SPY1_HUMAN No
SSA27_HUMAN No
FAK1_HUMAN No
STA5B_HUMAN No
ERBIN_HUMAN No
RFA2_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
P85A_HUMAN Yes: P27986 (MoonDB)
LCK_HUMAN No
P85B_HUMAN No
IGF1R_HUMAN No
CBL_HUMAN No
1A01_HUMAN No
1A03_HUMAN No
ABL2_HUMAN Yes: P42684 (MoonDB)
ADRB2_HUMAN Yes: P07550 (MoonDB)
AMBP_HUMAN No
ATF3_HUMAN No
BATF3_HUMAN No
BCKD_HUMAN No
BICD1_HUMAN No
BMX_HUMAN No
BRWD1_HUMAN No
CAH8_HUMAN No
CAN1_HUMAN No
CCD87_HUMAN No
CNDP2_HUMAN No
CPNS1_HUMAN No
CREST_HUMAN No
CTF18_HUMAN No
DOK2_HUMAN No
DOK3_HUMAN No
DTNA_HUMAN No
ECH1_HUMAN No
ECHM_HUMAN No
ELP2_HUMAN No
F117B_HUMAN No
FGR_HUMAN No
FOG2_HUMAN No
GNL3_HUMAN No
GSTCD_HUMAN No
HDAC2_HUMAN No
HESX1_HUMAN No
HNRPM_HUMAN No
HXC11_HUMAN No
I22R1_HUMAN No
IKBZ_HUMAN No
IMDH2_HUMAN No
IRAK3_HUMAN No
KLF15_HUMAN No
KSYK_HUMAN Yes: P43405 (MoonDB)
LAMB2_HUMAN No
M3K13_HUMAN No
MAPK2_HUMAN No
MNDA_HUMAN No
MORC4_HUMAN No
MPZL1_HUMAN No
NACAD_HUMAN No
NDUAD_HUMAN No
NFKB1_HUMAN No
NR4A1_HUMAN Yes: P22736 (MoonDB)
OFCC1_HUMAN No
OGDHL_HUMAN No
P121A_HUMAN No
PA1B2_HUMAN No
PAQR7_HUMAN No
PELP1_HUMAN No
PGFRA_HUMAN No
PGFRB_HUMAN No
PHS2_HUMAN No
PIAS3_HUMAN No
PINK1_HUMAN No
PPARD_HUMAN No
PTMA_HUMAN No
PTN1_HUMAN No
PTPRD_HUMAN No
Q6ZVU3_HUMAN No
RAC1_HUMAN No
RBGP1_HUMAN No
RET_HUMAN No
RL11_HUMAN No
RS9_HUMAN No
RT31_HUMAN No
SCAFB_HUMAN No
SH22A_HUMAN Yes: Q9NP31 (MoonDB)
SIAH2_HUMAN No
SORCN_HUMAN No
SP1_HUMAN No
SP20H_HUMAN No
SRRT_HUMAN No
ST2A1_HUMAN No
STAT1_HUMAN No
STAT6_HUMAN No
T4S19_HUMAN No
TDG_HUMAN No
TWST1_HUMAN No
VPS39_HUMAN No
WDFY3_HUMAN No
ZEP1_HUMAN Yes: P15822 (MoonDB)
ZN281_HUMAN No
ZN557_HUMAN No
ZN829_HUMAN No
PMID Article Title
7512451 Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
7701321 Requirement of serine phosphorylation for formation of STAT-promoter complexes.
9388184 Specific inhibition of Stat3 signal transduction by PIAS3.
9630560 Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.
10688651 Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
11773079 Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
12023369 A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
12208879 Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.
12359225 The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
12763138 Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.
12873986 Identification and characterization of signal transducer and activator of transcription 3 recruitment sites within the epidermal growth factor receptor.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15194700 Characterization of the signaling capacities of the novel gp130-like cytokine receptor.
15465816 IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression.
15467733 TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15677474 Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.
15919823 STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3.
15994929 Proline-, glutamic acid-, and leucine-rich protein-1 is essential in growth factor regulation of signal transducers and activators of transcription 3 activation.
16219639 Physical and functional interactions between STAT3 and ZIP kinase.
16568091 Identification of STAT3 as a specific substrate of breast tumor kinase.
16625196 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
17344214 leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3.
17676033 Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome.
17875724 Protein kinase Cepsilon interacts with signal transducers and activators of transcription 3 (Stat3), phosphorylates Stat3Ser727, and regulates its constitutive activation in prostate cancer.
17881745 STAT3 mutations in the hyper-IgE syndrome.
17956865 The functional role of an interleukin 6-inducible CDK9.STAT3 complex in human gamma-fibrinogen gene expression.
18070987 Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts.
18234692 BART is essential for nuclear retention of STAT3.
18242580 up-regulation of survivin by leptin/STAT3 signaling in MCF-7 cells.
18599021 Role for DYRK family kinases on regulation of apoptosis.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19147545 The Fer tyrosine kinase cooperates with interleukin-6 to activate signal transducer and activator of transcription 3 and promote human prostate cancer cell growth.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20826784 Acetylation directs survivin nuclear localization to repress STAT3 oncogenic activity.
21135090 Mechanisms of STAT protein activation by oncogenic KIT mutants in neoplastic mast cells.
21269460 Initial characterization of the human central proteome.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23084476 Cytoplasmic STAT3 represses autophagy by inhibiting PKR activity.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23342295 Signal transducer and activator of transcription 3 mutation with invasive eosinophilic disease.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25038750 Activating germline mutations in STAT3 cause early-onset multi-organ autoimmune disease.
25476455 Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity.
26293184 Functional characterization of two new STAT3 mutations associated with hyper-IgE syndrome in a Mexican cohort.
26675719 Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site.
28065600 Lysyl oxidase 3 is a dual-specificity enzyme involved in STAT3 deacetylation and deacetylimination modulation.
28073828 An activating mutation in STAT3 results in neonatal diabetes through reduced insulin synthesis.
OMIM ID Disease Name
147060 Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant
615952 Autoimmune disease, multisystem, infantile-onset, 1
Domain Name Domain ID Source
A54444 A54444 PIR
SH2 IPR000980 InterPro
STAT IPR001217 InterPro
p53-like_TF_DNA-bd IPR008967 InterPro
STAT_TF_DNA-bd_N IPR012345 InterPro
STAT_TF_prot_interaction IPR013799 InterPro
STAT_TF_alpha IPR013800 InterPro
STAT_TF_DNA-bd IPR013801 InterPro
STAT_TF_coiled-coil IPR015988 InterPro
STAT3_SH2 IPR035855 InterPro
STAT_N_sf IPR036535 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
STAT_alpha PF01017 Pfam
STAT_bind PF02864 Pfam
STAT_int PF02865 Pfam
SH2 PS50001 PROSITE
PTHR11801 PTHR11801 PANTHER
STAT_int SM00964 SMART
SSF47655 SSF47655 SUPFAM
SSF48092 SSF48092 SUPFAM
SSF49417 SSF49417 SUPFAM
SSF55550 SSF55550 SUPFAM
SH2_STAT3 cd10374 CDD