Protein: P40763 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P40763 (Uniprot)	STAT3_HUMAN	STAT3	Signal transducer and activator of transcription 3	human	No

Protein Function

Uniprot: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors (PubMed:10688651, PubMed:12359225, PubMed:12873986, PubMed:15194700, PubMed:17344214, PubMed:18242580, PubMed:23084476). Once activated, recruits coactivators, such as NCOA1 or M more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0006725	cellular aromatic compound metabolic process	222	GO:0006928	movement of cell or subcellular component	496	1.24e-32	2.63e-196
GO:0006928	movement of cell or subcellular component	496	GO:0006139	nucleobase-containing compound metabolic process	804	1.95e-31	6.36e-195
GO:0007165	signal transduction	187	GO:0034641	cellular nitrogen compound metabolic process	35, 810	4.22e-144	6.90e-18
GO:0007165	signal transduction	187	GO:0006725	cellular aromatic compound metabolic process	222, 736	5.44e-126	5.27e-27
GO:0007165	signal transduction	187	GO:0006139	nucleobase-containing compound metabolic process	804	1.10e-111	5.07e-25
GO:0007166	cell surface receptor signaling pathway	108	GO:0034641	cellular nitrogen compound metabolic process	35, 810	5.53e-55	9.57e-64
GO:0007166	cell surface receptor signaling pathway	108	GO:0006725	cellular aromatic compound metabolic process	222, 736	3.09e-47	2.24e-87
GO:0007166	cell surface receptor signaling pathway	108	GO:0006139	nucleobase-containing compound metabolic process	804	6.88e-41	1.21e-84
GO:0034641	cellular nitrogen compound metabolic process	35	GO:0006928	movement of cell or subcellular component	496	7.55e-40	5.63e-168

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
10	GO:0007165	signal transduction
35	GO:0044271	cellular nitrogen compound biosynthetic process
35	GO:0044267	cellular protein metabolic process
35	GO:0090304	nucleic acid metabolic process
35	GO:0010468	regulation of gene expression
35	GO:0009966	regulation of signal transduction
108	GO:0007167	enzyme linked receptor protein signaling pathway
108	GO:0006139	nucleobase-containing compound metabolic process
108	GO:0031325	positive regulation of cellular metabolic process
108	GO:1902533	positive regulation of intracellular signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
35	GO:0005829	cytosol
35	GO:0005634	nucleus
35	GO:0005886	plasma membrane
108	GO:0005829	cytosol
108	GO:0005634	nucleus
108	GO:0005886	plasma membrane
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
120	GO:0005829	cytosol
120	GO:0043232	intracellular non-membrane-bounded organelle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	TAS
GO:0001659	temperature homeostasis	ISS
GO:0001754	eye photoreceptor cell differentiation	ISS
GO:0006355	regulation of transcription, DNA-templated	IDA
GO:0006357	regulation of transcription from RNA polymerase II promoter	ISS
GO:0006606	protein import into nucleus	IDA
GO:0006928	movement of cell or subcellular component	TAS
GO:0006953	acute-phase response	IEA
GO:0006954	inflammatory response	ISS
GO:0007165	signal transduction	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000790	nuclear chromatin	IDA
GO:0005634	nucleus	IDA
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005743	mitochondrial inner membrane	IEA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	ISS
GO:0090575	RNA polymerase II transcription factor complex	IMP

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 7 of 7 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000790	nuclear chromatin	GO:0005737	cytoplasm	4.55e-08	5.17e-23
GO:0000790	nuclear chromatin	GO:0005886	plasma membrane	1.05e-21	5.03e-79
GO:0005634	nucleus	GO:0005886	plasma membrane	5.35e-300	7.52e-165
GO:0005654	nucleoplasm	GO:0005743	mitochondrial inner membrane	5.37e-05	2.97e-03
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005743	mitochondrial inner membrane	GO:0005829	cytosol	6.20e-17	9.93e-03
GO:0005886	plasma membrane	GO:0090575	RNA polymerase II transcription factor complex	4.33e-11	1.61e-73

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1A01_HUMAN	No
1A03_HUMAN	No
3BP2_HUMAN	No
ABL2_HUMAN	Yes: P42684 (MoonDB)
ADRB2_HUMAN	Yes: P07550 (MoonDB)
AMBP_HUMAN	No
ARFP2_HUMAN	No
ASXL1_HUMAN	No
ATF3_HUMAN	No
BATF3_HUMAN	No

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Publications Associated

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PMID	Article Title
7512451	Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.
7701321	Requirement of serine phosphorylation for formation of STAT-promoter complexes.
9388184	Specific inhibition of Stat3 signal transduction by PIAS3.
9630560	Highly conserved amino-acid sequence between murine STAT3 and a revised human STAT3 sequence.
10688651	Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation.
11773079	Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a.
12023369	A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R.
12208879	Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation.
12359225	The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation.
12763138	Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway.

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OMIM Diseases Associated

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OMIM ID	Disease Name
147060	Hyperimmunoglobulin E recurrent infection syndrome, autosomal dominant
615952	Autoimmune disease, multisystem, infantile-onset, 1

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Protein Domains Associated

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Domain Name	Domain ID	Source
A54444	A54444	PIR
p53-like_TF_DNA-bd	IPR008967	InterPro
PTHR11801	PTHR11801	PANTHER
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2_dom_sf	IPR036860	InterPro
SH2_STAT3	cd10374	CDD
SSF47655	SSF47655	SUPFAM
SSF48092	SSF48092	SUPFAM

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