Protein: P62328

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P62328 (Uniprot) TYB4_HUMAN TMSB4X Thymosin beta-4 human Yes
Uniprot: Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.Seraspenide inhibits the entry of hematopoietic pluripotent stem cells into the S-phase.
Dissimilar Functions Manual Curation

Function 1: Sequesters actin monomers.

Function 2: Secreted chemotaxis ligand. Extracellular modulator of biological processes, including cell migration, angiogenesis, wound healing, inflammation, and development. Condition: extracellular localisation.

Publications (PMID): 10581087, 21106936

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
51 GO:0060255 regulation of macromolecule metabolic process
67 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
51 GO:0005634 nucleus
67 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001649 osteoblast differentiation IEA
GO:0002576 platelet degranulation TAS
GO:0007015 actin filament organization IEA
GO:0007253 cytoplasmic sequestering of NF-kappaB IMP
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
GO:0033209 tumor necrosis factor-mediated signaling pathway IMP
GO:0042989 sequestering of actin monomers IDA
GO:0043536 positive regulation of blood vessel endothelial cell migration IGI
GO:0050727 regulation of inflammatory response IMP
GO:1901222 regulation of NIK/NF-kappaB signaling IGI
GO:1901223 negative regulation of NIK/NF-kappaB signaling IMP
GO:1903026 negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding IDA
GO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism IDA
GO:2000483 negative regulation of interleukin-8 secretion IDA
GO:2001028 positive regulation of endothelial cell chemotaxis IDA
GO:2001171 positive regulation of ATP biosynthetic process IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region TAS
GO:0005622 intracellular IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol IDA
GO:0005856 cytoskeleton IEA
GO:0031093 platelet alpha granule lumen TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005622 intracellular 8.27e-38 5.46e-09
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
PMID Article Title
1999398 Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable.
3500230 Differential expression of the human thymosin-beta 4 gene in lymphocytes, macrophages, and granulocytes.
6548414 Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells.
10848969 Structural requirements for thymosin beta4 in its contact with actin. An NMR-analysis of thymosin beta4 mutants in solution and correlation with their biological activity.
16010977 Molecular cloning and structural characterization of the functional human thymosin beta4 gene.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
23009842 Structural states and dynamics of the D-loop in actin.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
25946035 Human basal tear peptidome characterization by CID, HCD, and ETD followed by in silico and in vitro analyses for antimicrobial peptide identification.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
A38682 I56000 PIR
Beta-thymosin IPR001152 InterPro
Beta-thymosin_sf IPR038386 InterPro
Thymosin_b4 PD005116 ProDom
Thymosin PF01290 Pfam
Thymosin_beta PIRSF001828 PIRSF
THYMOSIN_B4 PS00500 PROSITE
PTHR12021 PTHR12021 PANTHER
THY SM00152 SMART