Protein: P0DP23 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P0DP23 (Uniprot)	CALM1_HUMAN	CALM1	Calmodulin-1	human	No

Protein Function

Uniprot: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathw more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	4	GO:0006725	cellular aromatic compound metabolic process	53	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
4	GO:0035556	intracellular signal transduction
4	GO:0031399	regulation of protein modification process
4	GO:0009966	regulation of signal transduction
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
172	GO:0060255	regulation of macromolecule metabolic process
359	GO:0044248	cellular catabolic process
359	GO:0000209	protein polyubiquitination
359	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
4	GO:0005829	cytosol
4	GO:0005634	nucleus
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
359	GO:0005634	nucleus
381	GO:0005829	cytosol
381	GO:0005634	nucleus
419	GO:0044430	cytoskeletal part
419	GO:0005829	cytosol
774	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000165	MAPK cascade	TAS
GO:0002027	regulation of heart rate	IMP
GO:0002576	platelet degranulation	TAS
GO:0005513	detection of calcium ion	IMP
GO:0005980	glycogen catabolic process	TAS
GO:0006479	protein methylation	TAS
GO:0006936	muscle contraction	TAS
GO:0007223	Wnt signaling pathway, calcium modulating pathway	TAS
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	TAS
GO:0010801	negative regulation of peptidyl-threonine phosphorylation	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000922	spindle pole	IEA
GO:0005576	extracellular region	TAS
GO:0005654	nucleoplasm	TAS
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	TAS
GO:0014069	postsynaptic density	IEA
GO:0030017	sarcomere	IDA
GO:0034704	calcium channel complex	IDA
GO:0043234	protein complex	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0000922	spindle pole	GO:0005886	plasma membrane	4.24e-02	6.65e-62
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005654	nucleoplasm	GO:0005886	plasma membrane	9.14e-199	6.17e-196
GO:0005886	plasma membrane	GO:1902494	catalytic complex	3.04e-46	1.13e-37

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433E_HUMAN	Yes: P62258 (MoonDB)
A0JP07_HUMAN	No
ADCY8_HUMAN	No
AKAP9_HUMAN	No
APBP2_HUMAN	No
AT2B4_HUMAN	No
ATS12_HUMAN	No
CAC1A_HUMAN	No
CAC1C_HUMAN	No
CD003_HUMAN	No

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Publications Associated

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PMID	Article Title
1474585	Calmodulin structure refined at 1.7 A resolution.
6385987	Isolation and nucleotide sequence of a cDNA encoding human calmodulin.
7093203	Complete amino acid sequence of human brain calmodulin.
7803388	Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.
7925473	Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2.
9804419	Structural basis for activation of the titin kinase domain during myofibrillogenesis.
9927666	Alpha-helix nucleation by a calcium-binding peptide loop.
11685248	Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.
11807546	Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
12485993	Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614916	Ventricular tachycardia, catecholaminergic polymorphic, 4
616247	Long QT syndrome 14

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Protein Domains Associated

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Domain Name	Domain ID	Source
EF-hand-dom_pair	IPR011992	InterPro
EF-hand_7	PF13499	Pfam
EF_HAND_1	PS00018	PROSITE
EF_Hand_1_Ca_BS	IPR018247	InterPro
EF_HAND_2	PS50222	PROSITE
EF_hand_dom	IPR002048	InterPro
EFh	SM00054	SMART
EFh	cd00051	CDD
MCHU	S48728	PIR
SSF47473	SSF47473	SUPFAM

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