Protein: P00558

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P00558 (Uniprot) PGK1_HUMAN PGK1 Phosphoglycerate kinase 1 human Yes
Uniprot: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).
Dissimilar Functions Manual Curation

Function 1: Glycolytic enzyme. Phosphoglycerate kinase.

Function 2: Plasmin reductase. Polymerase alpha cofactor protein. Condition: cancer (secreted).

Publications (PMID): 11130727, 2324090

Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
536 GO:0010604 positive regulation of macromolecule metabolic process
536 GO:0051173 positive regulation of nitrogen compound metabolic process
536 GO:0019538 protein metabolic process
536 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
536 GO:0005829 cytosol
536 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006094 gluconeogenesis TAS
GO:0006096 glycolytic process IMP
GO:0016310 phosphorylation ISS
GO:0016525 negative regulation of angiogenesis IMP
GO:0030855 epithelial cell differentiation IEP
GO:0031639 plasminogen activation IMP
GO:0061621 canonical glycolysis TAS
GO:0071456 cellular response to hypoxia IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005615 extracellular space IDA
GO:0005829 cytosol TAS
GO:0016020 membrane IDA
GO:0045121 membrane raft IDA
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1547346 A single amino acid substitution (157 Gly-->Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria.
1586722 Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.
2001457 Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu-->Pro substitution caused by T/A-->C/G transition in exon 3.
2324090 Functional identity of a primer recognition protein as phosphoglycerate kinase.
2814502 Genomic sequencing and methylation analysis by ligation mediated PCR.
2995995 Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.
6099325 Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase].
6188151 Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
6933565 Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia.
6941312 Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia.
7391027 Complete amino acid sequence of human phosphoglycerate kinase. Cyanogen bromide peptides and complete amino acid sequence.
7391028 A single amino acid substitution (Asp leads to Asn) in a phosphoglycerate kinase variant (PGK Munchen) associated with enzyme deficiency.
7440217 Structure and function of normal and variant human phosphoglycerate kinase.
8043870 Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Creteil and PGK Amiens.
8615693 Retarded and aberrant splicings caused by single exon mutation in a phosphoglycerate kinase variant.
8673469 Molecular abnormality of a phosphoglycerate kinase variant (PGK-Alabama).
9075577 Hematologically important mutations: molecular abnormalities of phosphoglycerate kinase.
9744480 A phosphoglycerate kinase mutant (PGK Herlev; D285V) in a Danish patient with isolated chronic hemolytic anemia: mechanism of mutation and structure-function relationships.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15772651 The DNA sequence of the human X chromosome.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
18463139 Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase.
18669648 A quantitative atlas of mitotic phosphorylation.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21908771 The first identification of lysine malonylation substrates and its regulatory enzyme.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
26677959 Characteristics of testis-specific phosphoglycerate kinase 2 and its association with human sperm quality.
OMIM ID Disease Name
300653 Phosphoglycerate kinase 1 deficiency
Domain Name Domain ID Source
KIHUG I59050 PIR
Phosphoglycerate_kinase IPR001576 InterPro
Phosphoglycerate_kinase_N IPR015824 InterPro
Phosphoglycerate_kinase_CS IPR015911 InterPro
Phosphoglycerate_kinase_sf IPR036043 InterPro
Phosphoglyc_kinase MF_00145 HAMAP
PGK PF00162 Pfam
Pgk PIRSF000724 PIRSF
PHGLYCKINASE PR00477 PRINTS
PGLYCERATE_KINASE PS00111 PROSITE
PTHR11406 PTHR11406 PANTHER
SSF53748 SSF53748 SUPFAM
Phosphoglycerate_kinase cd00318 CDD