Protein: P00558 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P00558 (Uniprot)	PGK1_HUMAN	PGK1	Phosphoglycerate kinase 1	human	Yes

Protein Function

Uniprot: In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein) (PubMed:2324090). May play a role in sperm motility (PubMed:26677959).

Dissimilar Functions Manual Curation

Function 1: Glycolytic enzyme. Phosphoglycerate kinase.

Function 2: Plasmin reductase. Polymerase alpha cofactor protein. Condition: cancer (secreted).

Publications (PMID): 11130727, 2324090

MoonDB Network Modules

Biological Processes

Showing 1 to 4 of 4 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
536	GO:0010604	positive regulation of macromolecule metabolic process
536	GO:0051173	positive regulation of nitrogen compound metabolic process
536	GO:0019538	protein metabolic process
536	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
536	GO:0005829	cytosol
536	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006094	gluconeogenesis	TAS
GO:0006096	glycolytic process	IMP
GO:0016310	phosphorylation	ISS
GO:0016525	negative regulation of angiogenesis	IMP
GO:0030855	epithelial cell differentiation	IEP
GO:0031639	plasminogen activation	IMP
GO:0061621	canonical glycolysis	TAS
GO:0071456	cellular response to hypoxia	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005615	extracellular space	IDA
GO:0005829	cytosol	TAS
GO:0016020	membrane	IDA
GO:0045121	membrane raft	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
DISC1_HUMAN	Yes: Q9NRI5 (MoonDB)
G3P_HUMAN	Yes: P04406 (MoonDB)
PCNA_HUMAN	Yes: P12004 (MoonDB)
UBB_HUMAN	Yes: P0CG47 (MoonDB)

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Publications Associated

Showing 1 to 10 of 35 entries

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PMID	Article Title
1547346	A single amino acid substitution (157 Gly-->Val) in a phosphoglycerate kinase variant (PGK Shizuoka) associated with chronic hemolysis and myoglobinuria.
1586722	Molecular abnormalities of a phosphoglycerate kinase variant generated by spontaneous mutation.
2001457	Molecular defect of a phosphoglycerate kinase variant (PGK-Matsue) associated with hemolytic anemia: Leu-->Pro substitution caused by T/A-->C/G transition in exon 3.
2324090	Functional identity of a primer recognition protein as phosphoglycerate kinase.
2814502	Genomic sequencing and methylation analysis by ligation mediated PCR.
2995995	Structure of the human phosphoglycerate kinase gene and the intron-mediated evolution and dispersal of the nucleotide-binding domain.
6099325	Sequence of the promoter region of the gene for human X-linked 3-phosphoglycerate kinase].
6188151	Isolation and DNA sequence of a full-length cDNA clone for human X chromosome-encoded phosphoglycerate kinase.
6933565	Molecular abnormality of phosphoglycerate kinase-Uppsala associated with chronic nonspherocytic hemolytic anemia.
6941312	Use of cultured lymphoblastoid cells for the study of abnormal enzymes: molecular abnormality of a phosphoglycerate kinase variant associated with hemolytic anemia.

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OMIM Diseases Associated

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OMIM ID	Disease Name
300653	Phosphoglycerate kinase 1 deficiency

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Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
KIHUG	I59050	PIR
PGK	PF00162	Pfam
Pgk	PIRSF000724	PIRSF
PGLYCERATE_KINASE	PS00111	PROSITE
PHGLYCKINASE	PR00477	PRINTS
Phosphoglyc_kinase	MF_00145	HAMAP
Phosphoglycerate_kinase	IPR001576	InterPro
Phosphoglycerate_kinase	cd00318	CDD
Phosphoglycerate_kinase_CS	IPR015911	InterPro
Phosphoglycerate_kinase_N	IPR015824	InterPro

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