Protein: P51948 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P51948 (Uniprot)	MAT1_HUMAN	MNAT1	CDK-activating kinase assembly factor MAT1	human	No

Protein Function

Uniprot: Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylat more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	5, 384	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
5	GO:0034645	cellular macromolecule biosynthetic process
5	GO:0006464	cellular protein modification process
5	GO:0090304	nucleic acid metabolic process
5	GO:0034654	nucleobase-containing compound biosynthetic process
5	GO:0060255	regulation of macromolecule metabolic process
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
198	GO:0060255	regulation of macromolecule metabolic process
198	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
5	GO:0005829	cytosol
5	GO:0005634	nucleus
125	GO:0005829	cytosol
125	GO:0005634	nucleus
198	GO:0005829	cytosol
384	GO:0005829	cytosol
384	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity	TAS
GO:0000082	G1/S transition of mitotic cell cycle	TAS
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0006281	DNA repair	TAS
GO:0006283	transcription-coupled nucleotide-excision repair	TAS
GO:0006294	nucleotide-excision repair, preincision complex assembly	TAS
GO:0006357	regulation of transcription from RNA polymerase II promoter	IDA
GO:0006361	transcription initiation from RNA polymerase I promoter	TAS
GO:0006362	transcription elongation from RNA polymerase I promoter	TAS
GO:0006363	termination of RNA polymerase I transcription	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005654	nucleoplasm	TAS
GO:0005675	holo TFIIH complex	IDA
GO:0005829	cytosol	IDA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
BEX3_HUMAN	No
BRCA1_HUMAN	No
CCNH_HUMAN	No
CSN6_HUMAN	No
DMAP1_HUMAN	No
EF1A1_HUMAN	No
FOXP1_HUMAN	No
HPS6_HUMAN	No
LRIF1_HUMAN	No
MAGC2_HUMAN	No

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Publications Associated

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PMID	Article Title
8521393	Molecular cloning of CDK7-associated human MAT1, a cyclin-dependent kinase-activating kinase (CAK) assembly factor.
8521818	In vitro assembly of a functional human CDK7-cyclin H complex requires MAT1, a novel 36 kDa RING finger protein.
9852112	Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes.
10024882	Reconstitution of the transcription factor TFIIH: assignment of functions for the three enzymatic subunits, XPB, XPD, and cdk7.
11056162	Solution structure of the N-terminal domain of the human TFIIH MAT1 subunit: new insights into the RING finger family.
12508121	The DNA sequence and analysis of human chromosome 14.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18691976	Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19369195	Large-scale proteomics analysis of the human kinome.
19413330	Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 17 entries

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Domain Name	Domain ID	Source
Cdk-activating_kinase_MAT1_cen	IPR015877	InterPro
cdk7	TIGR00570	TIGRFAMs
G02764	G02764	PIR
MAT1	PF06391	Pfam
MAT1/Tfb3	IPR004575	InterPro
MAT1_metazoa	PIRSF003338	PIRSF
PTHR12683:SF13	PTHR12683:SF13	PANTHER
RING	SM00184	SMART
S60157	S60157	PIR
UIM	PS50330	PROSITE

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