Protein: Q8N8N0 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8N8N0 (Uniprot)	RN152_HUMAN	RNF152	E3 ubiquitin-protein ligase RNF152	human	No

Protein Function

Uniprot: E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins an more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	355	GO:0006725	cellular aromatic compound metabolic process	53	5.44e-126	5.27e-27

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 15 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
53	GO:0006139	nucleobase-containing compound metabolic process
53	GO:0016567	protein ubiquitination
53	GO:0060255	regulation of macromolecule metabolic process
175	GO:0044267	cellular protein metabolic process
175	GO:0006139	nucleobase-containing compound metabolic process
175	GO:0010468	regulation of gene expression
355	GO:0007166	cell surface receptor signaling pathway
355	GO:0006464	cellular protein modification process
355	GO:0035556	intracellular signal transduction
355	GO:0016310	phosphorylation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
53	GO:0005829	cytosol
53	GO:0005654	nucleoplasm
175	GO:0005829	cytosol
175	GO:0005634	nucleus
355	GO:0044459	plasma membrane part

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006915	apoptotic process	TAS
GO:0010508	positive regulation of autophagy	IMP
GO:0016567	protein ubiquitination	TAS
GO:0034198	cellular response to amino acid starvation	IDA
GO:0070534	protein K63-linked ubiquitination	IMP
GO:0070936	protein K48-linked ubiquitination	IDA
GO:1904262	negative regulation of TORC1 signaling	IMP

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005764	lysosome	IDA
GO:0005765	lysosomal membrane	TAS
GO:0031301	integral component of organelle membrane	IMP

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 5 of 5 entries

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Interactor	Also a MoonDB EMF protein
CROCC_HUMAN	No
KI2L3_HUMAN	No
UB2E1_HUMAN	Yes: P51965 (MoonDB)
UBE2N_HUMAN	Yes: P61088 (MoonDB)
UBE2W_HUMAN	Yes: Q96B02 (MoonDB)

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Publications Associated

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PMID	Article Title
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16177791	DNA sequence and analysis of human chromosome 18.
21203937	RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities.
25936802	The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 7 of 7 entries

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Domain Name	Domain ID	Source
PTHR25464	PTHR25464	PANTHER
RING	SM00184	SMART
RNF152	IPR033609	InterPro
zf-RING_5	PF14634	Pfam
ZF_RING_2	PS50089	PROSITE
Znf_RING	IPR001841	InterPro
Znf_RING/FYVE/PHD	IPR013083	InterPro

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