Protein: Q8N8N0

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q8N8N0 (Uniprot) RN152_HUMAN RNF152 E3 ubiquitin-protein ligase RNF152 human No
Uniprot: E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (PubMed:21203937). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 355 GO:0006725 cellular aromatic compound metabolic process 53 5.44e-126 5.27e-27
Module ID (MoonGO) GO ID (BP) GO Name
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
175 GO:0005829 cytosol
175 GO:0005634 nucleus
355 GO:0044459 plasma membrane part
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process TAS
GO:0010508 positive regulation of autophagy IMP
GO:0016567 protein ubiquitination TAS
GO:0034198 cellular response to amino acid starvation IDA
GO:0070534 protein K63-linked ubiquitination IMP
GO:0070936 protein K48-linked ubiquitination IDA
GO:1904262 negative regulation of TORC1 signaling IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005764 lysosome IDA
GO:0005765 lysosomal membrane TAS
GO:0031301 integral component of organelle membrane IMP
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16177791 DNA sequence and analysis of human chromosome 18.
21203937 RNF152, a novel lysosome localized E3 ligase with pro-apoptotic activities.
25936802 The ubiquitination of RagA GTPase by RNF152 negatively regulates mTORC1 activation.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
RNF152 IPR033609 InterPro
zf-RING_5 PF14634 Pfam