Protein: Q15843 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q15843 (Uniprot)	NEDD8_HUMAN	NEDD8	NEDD8	human	No

Protein Function

Uniprot: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, a more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	644	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
560	GO:0006464	cellular protein modification process
560	GO:0060255	regulation of macromolecule metabolic process
560	GO:0007165	signal transduction
644	GO:0032774	RNA biosynthetic process
644	GO:0034645	cellular macromolecule biosynthetic process
644	GO:0006464	cellular protein modification process
644	GO:0060255	regulation of macromolecule metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
560	GO:0005829	cytosol
644	GO:0031981	nuclear lumen
706	GO:0005829	cytosol
706	GO:0031981	nuclear lumen

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006357	regulation of transcription from RNA polymerase II promoter	IEA
GO:0006464	cellular protein modification process	TAS
GO:0006508	proteolysis	TAS
GO:0006511	ubiquitin-dependent protein catabolic process	TAS
GO:0006879	cellular iron ion homeostasis	TAS
GO:0007179	transforming growth factor beta receptor signaling pathway	TAS
GO:0008104	protein localization	IEA
GO:0009653	anatomical structure morphogenesis	TAS
GO:0014070	response to organic cyclic compound	IEA
GO:0016567	protein ubiquitination	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0005829	cytosol	TAS
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005654	nucleoplasm	GO:0070062	extracellular exosome	3.37e-20	1.23e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ATX3_HUMAN	No
CUL1_HUMAN	No
CUL3_HUMAN	No
CUL5_HUMAN	No
NUB1_HUMAN	No
SENP8_HUMAN	No
UB2D2_HUMAN	Yes: P62837 (MoonDB)
UBA3_HUMAN	Yes: Q8TBC4 (MoonDB)
UBC12_HUMAN	No
UBC_HUMAN	Yes: P0CG48 (MoonDB)

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Publications Associated

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PMID	Article Title
9353319	Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein.
9694792	A new NEDD8-ligating system for cullin-4A.
9790970	Cleavage of the C-terminus of NEDD8 by UCH-L3.
9857030	Crystal structure of the human ubiquitin-like protein NEDD8 and interactions with ubiquitin pathway enzymes.
10318914	Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function.
10597293	Covalent modification of all members of human cullin family proteins by NEDD8.
11259415	NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression.
11953428	The NEDD8 pathway is essential for SCF(beta -TrCP)-mediated ubiquitination and processing of the NF-kappa B precursor p105.
12215427	Interaction with Nedd8, a ubiquitin-like protein, enhances the transcriptional activity of the aryl hydrocarbon receptor.
12730221	NEDP1, a highly conserved cysteine protease that deneddylates cullins.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
SSF54236	SSF54236	SUPFAM
Ubiquitin	IPR019956	InterPro
ubiquitin	PF00240	Pfam
UBIQUITIN	PR00348	PRINTS
Ubiquitin-like_domsf	IPR029071	InterPro
UBIQUITIN_1	PS00299	PROSITE
UBIQUITIN_2	PS50053	PROSITE
Ubiquitin_CS	IPR019954	InterPro
Ubiquitin_dom	IPR000626	InterPro
UBQ	SM00213	SMART

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