Protein: Q8TBC4 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q8TBC4 (Uniprot)	UBA3_HUMAN	UBA3	NEDD8-activating enzyme E1 catalytic subunit	human	No

Protein Function

Uniprot: Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	376	GO:0016070	RNA metabolic process	719	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 11 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
376	GO:0044267	cellular protein metabolic process
376	GO:0007165	signal transduction
644	GO:0032774	RNA biosynthetic process
644	GO:0034645	cellular macromolecule biosynthetic process
644	GO:0006464	cellular protein modification process
644	GO:0060255	regulation of macromolecule metabolic process
644	GO:0007165	signal transduction
719	GO:0006401	RNA catabolic process
719	GO:0016071	mRNA metabolic process
719	GO:0010629	negative regulation of gene expression

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
376	GO:0005829	cytosol
376	GO:0005634	nucleus
644	GO:0031981	nuclear lumen
719	GO:0005829	cytosol
719	GO:0043232	intracellular non-membrane-bounded organelle
719	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

Showing 1 to 8 of 8 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006464	cellular protein modification process	TAS
GO:0006508	proteolysis	TAS
GO:0007113	endomitotic cell cycle	IEA
GO:0038061	NIK/NF-kappaB signaling	TAS
GO:0043687	post-translational protein modification	TAS
GO:0045116	protein neddylation	IEA
GO:0045892	negative regulation of transcription, DNA-templated	IEA
GO:0051726	regulation of cell cycle	IEA

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Cellular Components

Showing 1 to 3 of 3 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IBA
GO:0005829	cytosol	TAS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

Showing 1 to 9 of 9 entries

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Interactor	Also a MoonDB EMF protein
CHD3_HUMAN	Yes: Q12873 (MoonDB)
CPNE2_HUMAN	No
DUS23_HUMAN	No
IMPA2_HUMAN	No
KDM1A_HUMAN	Yes: O60341 (MoonDB)
NEDD8_HUMAN	Yes: Q15843 (MoonDB)
UBC12_HUMAN	No
UBE2F_HUMAN	No
ULA1_HUMAN	No

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Publications Associated

Showing 1 to 10 of 14 entries

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PMID	Article Title
9694792	A new NEDD8-ligating system for cullin-4A.
10207026	Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway.
11230166	Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
12646924	Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8.
12740388	Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
14690597	The structure of the APPBP1-UBA3-NEDD8-ATP complex reveals the basis for selective ubiquitin-like protein activation by an E1.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15361859	A unique E1-E2 interaction required for optimal conjugation of the ubiquitin-like protein NEDD8.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15694336	Structural basis for recruitment of Ubc12 by an E2 binding domain in NEDD8's E1.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 13 entries

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Domain Name	Domain ID	Source
E2_bind	PF08825	Pfam
E2_bind	SM01181	SMART
E2_binding	IPR014929	InterPro
NEDD8-ac_enz1_catalyticsu_C	IPR037078	InterPro
PTHR10953:SF6	PTHR10953:SF6	PANTHER
SSF69572	SSF69572	SUPFAM
T17306	T17306	PIR
ThiF	PF00899	Pfam
ThiF_NAD_FAD-bd	IPR000594	InterPro
Uba3	IPR030468	InterPro

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