Protein: P09382

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P09382 (Uniprot) LEG1_HUMAN LGALS1 Galectin-1 human Yes
Uniprot: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.
Dissimilar Functions Manual Curation

Function 1: Multiple signalling functions. Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Condition: intracellular localisation.

Function 2: Anti-influenza virus activity by binding to viral surface and inhibiting its infectivity. Condition: extracellular localisation.

Publications (PMID): 18354082, 21795357

GO ID (BP) GO Name Evidence Code (GO EC)
GO:0002317 plasma cell differentiation IEA
GO:0006915 apoptotic process IEA
GO:0007165 signal transduction IEA
GO:0010812 negative regulation of cell-substrate adhesion IEA
GO:0010977 negative regulation of neuron projection development IEA
GO:0031295 T cell costimulation IEA
GO:0034120 positive regulation of erythrocyte aggregation IEA
GO:0035900 response to isolation stress IEA
GO:0042493 response to drug IEA
GO:0042981 regulation of apoptotic process TAS
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
GO:0043687 post-translational protein modification TAS
GO:0044267 cellular protein metabolic process TAS
GO:0045445 myoblast differentiation IEA
GO:0046598 positive regulation of viral entry into host cell IDA
GO:0048678 response to axon injury IEA
GO:0071333 cellular response to glucose stimulus IEA
GO:0071407 cellular response to organic cyclic compound IEA
GO:2001200 positive regulation of dendritic cell differentiation IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005576 extracellular region IDA
GO:0005578 proteinaceous extracellular matrix IEA
GO:0005615 extracellular space IDA
GO:0005622 intracellular IDA
GO:0005634 nucleus IEA
GO:0005737 cytoplasm TAS
GO:0005788 endoplasmic reticulum lumen TAS
GO:0005829 cytosol IEA
GO:0009986 cell surface IEA
GO:0031012 extracellular matrix ISS
GO:0070062 extracellular exosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005576 extracellular region GO:0005622 intracellular 8.27e-38 5.46e-09
GO:0005576 extracellular region GO:0005634 nucleus 4.48e-91 1.28e-107
GO:0005578 proteinaceous extracellular matrix GO:0005622 intracellular 4.02e-13 5.28e-09
GO:0005578 proteinaceous extracellular matrix GO:0005634 nucleus 2.57e-32 8.63e-63
GO:0005578 proteinaceous extracellular matrix GO:0005737 cytoplasm 3.97e-02 1.23e-03
GO:0005578 proteinaceous extracellular matrix GO:0005829 cytosol 1.62e-25 2.76e-131
GO:0005615 extracellular space GO:0005622 intracellular 1.63e-10 4.39e-07
GO:0005615 extracellular space GO:0005634 nucleus 6.26e-54 1.10e-77
GO:0005622 intracellular GO:0009986 cell surface 1.98e-26 5.24e-13
GO:0005634 nucleus GO:0005788 endoplasmic reticulum lumen 1.02e-17 1.08e-83
GO:0005634 nucleus GO:0009986 cell surface 1.10e-44 1.49e-81
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005788 endoplasmic reticulum lumen GO:0005829 cytosol 5.39e-12 7.02e-64
GO:0005829 cytosol GO:0009986 cell surface 3.26e-22 6.81e-06
GO:0005829 cytosol GO:0031012 extracellular matrix 4.46e-06 5.18e-08
PMID Article Title
1386213 Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin.
1988031 Genomic sequence and organization of two members of a human lectin gene family.
2383549 Human splenic galaptin: physicochemical characterization.
2719646 Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene.
2719964 Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.
2910856 Molecular cloning, characterization, and expression of a human 14-kDa lectin.
3065332 Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta.
3611046 Further characterization and structural studies on human placenta lectin.
7501023 Apoptosis of T cells mediated by galectin-1.
10369126 Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.
10591208 The DNA sequence of human chromosome 22.
10764829 Regulation of CD45-induced signaling by galectin-1 in Burkitt lymphoma B cells.
11146440 Glycoprotein 90K/MAC-2BP interacts with galectin-1 and mediates galectin-1-induced cell aggregation.
12665801 Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
12761501 Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways.
14617626 Presentation of galectin-1 by extracellular matrix triggers T cell death.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15461802 A genome annotation-driven approach to cloning the human ORFeome.
15476813 Growth-regulatory human galectin-1: crystallographic characterisation of the structural changes induced by single-site mutations and their impact on the thermodynamics of ligand binding.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
18796645 Functional and structural bases of a cysteine-less mutant as a long-lasting substitute for galectin-1.
18824694 Emergence of hormonal and redox regulation of galectin-1 in placental mammals: implication in maternal-fetal immune tolerance.
19128029 Critical role of the solvent environment in galectin-1 binding to the disaccharide lactose.
19497882 A primate subfamily of galectins expressed at the maternal-fetal interface that promote immune cell death.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
21269460 Initial characterization of the human central proteome.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22905912 Resveratrol-induced changes of the human adipocyte secretion profile.
23131994 Multiple functions of sushi domain containing 2 (SUSD2) in breast tumorigenesis.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24945728 Modulation of CD6 function through interaction with galectin-1 and -3.
25944712 N-terminome analysis of the human mitochondrial proteome.
26091039 A single kinase generates the majority of the secreted phosphoproteome.
No results found.
Domain Name Domain ID Source
LNHUGB A37134 PIR
Galectin_CRD IPR001079 InterPro
ConA-like_dom_sf IPR013320 InterPro
Gal-bind_lectin PF00337 Pfam
GALECTIN PS51304 PROSITE
GLECT SM00276 SMART
Gal-bind_lectin SM00908 SMART
SSF49899 SSF49899 SUPFAM
GLECT cd00070 CDD