Protein: P09382 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P09382 (Uniprot)	LEG1_HUMAN	LGALS1	Galectin-1	human	Yes

Protein Function

Uniprot: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis.

Dissimilar Functions Manual Curation

Function 1: Multiple signalling functions. Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Condition: intracellular localisation.

Function 2: Anti-influenza virus activity by binding to viral surface and inhibiting its infectivity. Condition: extracellular localisation.

Publications (PMID): 18354082, 21795357

MoonDB Network Modules

Biological Processes

No results found.

Cellular Components

No results found.

Protein GO Annotations

Biological Processes

Showing 1 to 10 of 19 entries

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002317	plasma cell differentiation	IEA
GO:0006915	apoptotic process	IEA
GO:0007165	signal transduction	IEA
GO:0010812	negative regulation of cell-substrate adhesion	IEA
GO:0010977	negative regulation of neuron projection development	IEA
GO:0031295	T cell costimulation	IEA
GO:0034120	positive regulation of erythrocyte aggregation	IEA
GO:0035900	response to isolation stress	IEA
GO:0042493	response to drug	IEA
GO:0042981	regulation of apoptotic process	TAS

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Cellular Components

Showing 1 to 10 of 11 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	IDA
GO:0005578	proteinaceous extracellular matrix	IEA
GO:0005615	extracellular space	IDA
GO:0005622	intracellular	IDA
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	TAS
GO:0005788	endoplasmic reticulum lumen	TAS
GO:0005829	cytosol	IEA
GO:0009986	cell surface	IEA
GO:0031012	extracellular matrix	ISS

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 10 of 16 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005622	intracellular	8.27e-38	5.46e-09
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005578	proteinaceous extracellular matrix	GO:0005622	intracellular	4.02e-13	5.28e-09
GO:0005578	proteinaceous extracellular matrix	GO:0005634	nucleus	2.57e-32	8.63e-63
GO:0005578	proteinaceous extracellular matrix	GO:0005737	cytoplasm	3.97e-02	1.23e-03
GO:0005578	proteinaceous extracellular matrix	GO:0005829	cytosol	1.62e-25	2.76e-131
GO:0005615	extracellular space	GO:0005622	intracellular	1.63e-10	4.39e-07
GO:0005615	extracellular space	GO:0005634	nucleus	6.26e-54	1.10e-77
GO:0005622	intracellular	GO:0009986	cell surface	1.98e-26	5.24e-13
GO:0005634	nucleus	GO:0005788	endoplasmic reticulum lumen	1.02e-17	1.08e-83

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All Protein Interactions

Showing 1 to 9 of 9 entries

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Interactor	Also a MoonDB EMF protein
AP2A_HUMAN	No
CD166_HUMAN	No
CD6_HUMAN	No
CDC42_HUMAN	Yes: P60953 (MoonDB)
GEMI4_HUMAN	No
HSPB2_HUMAN	No
NLGN3_HUMAN	No
UBP4_HUMAN	No
VGFR2_HUMAN	No

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Publications Associated

Showing 1 to 10 of 34 entries

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PMID	Article Title
1386213	Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin.
1988031	Genomic sequence and organization of two members of a human lectin gene family.
2383549	Human splenic galaptin: physicochemical characterization.
2719646	Evidence that the 14 kDa soluble beta-galactoside-binding lectin in man is encoded by a single gene.
2719964	Cloning and nucleotide sequence of a full-length cDNA for human 14 kDa beta-galactoside-binding lectin.
2910856	Molecular cloning, characterization, and expression of a human 14-kDa lectin.
3065332	Complete amino acid sequence of a beta-galactoside-binding lectin from human placenta.
3611046	Further characterization and structural studies on human placenta lectin.
7501023	Apoptosis of T cells mediated by galectin-1.
10369126	Galectin-1, a natural ligand for the receptor-type protein tyrosine phosphatase CD45.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 9 of 9 entries

Search:

Domain Name	Domain ID	Source
ConA-like_dom_sf	IPR013320	InterPro
Gal-bind_lectin	PF00337	Pfam
Gal-bind_lectin	SM00908	SMART
GALECTIN	PS51304	PROSITE
Galectin_CRD	IPR001079	InterPro
GLECT	SM00276	SMART
GLECT	cd00070	CDD
LNHUGB	A37134	PIR
SSF49899	SSF49899	SUPFAM

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