Protein: P61978

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P61978 (Uniprot) HNRPK_HUMAN HNRNPK Heterogeneous nuclear ribonucleoprotein K human No
Uniprot: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 294, 353 GO:0019538 protein metabolic process 379 1.88e-02 4.66e-37
GO:0019538 protein metabolic process 379 GO:0016070 RNA metabolic process 715 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
31 GO:0034645 cellular macromolecule biosynthetic process
31 GO:0044271 cellular nitrogen compound biosynthetic process
31 GO:0090304 nucleic acid metabolic process
31 GO:0010468 regulation of gene expression
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
70 GO:0051252 regulation of RNA metabolic process
70 GO:0010468 regulation of gene expression
70 GO:0006351 transcription, DNA-templated
80 GO:0051252 regulation of RNA metabolic process
80 GO:0010468 regulation of gene expression
127 GO:0016070 RNA metabolic process
127 GO:0010467 gene expression
160 GO:0006355 regulation of transcription, DNA-templated
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
191 GO:0006355 regulation of transcription, DNA-templated
259 GO:0007165 signal transduction
294 GO:0000398 mRNA splicing, via spliceosome
353 GO:0000398 mRNA splicing, via spliceosome
379 GO:0044267 cellular protein metabolic process
379 GO:0009059 macromolecule biosynthetic process
379 GO:0051246 regulation of protein metabolic process
426 GO:0008380 RNA splicing
426 GO:0006397 mRNA processing
426 GO:0051252 regulation of RNA metabolic process
426 GO:2000112 regulation of cellular macromolecule biosynthetic process
426 GO:0010468 regulation of gene expression
426 GO:0006351 transcription, DNA-templated
464 GO:0016070 RNA metabolic process
464 GO:0010467 gene expression
478 GO:0060255 regulation of macromolecule metabolic process
591 GO:0016070 RNA metabolic process
591 GO:0010467 gene expression
591 GO:0060255 regulation of macromolecule metabolic process
649 GO:0016070 RNA metabolic process
649 GO:0010468 regulation of gene expression
654 GO:0010467 gene expression
654 GO:0019538 protein metabolic process
654 GO:0060255 regulation of macromolecule metabolic process
681 GO:0008380 RNA splicing
681 GO:0006397 mRNA processing
681 GO:0051252 regulation of RNA metabolic process
681 GO:0010468 regulation of gene expression
715 GO:0006396 RNA processing
715 GO:0060255 regulation of macromolecule metabolic process
741 GO:0019438 aromatic compound biosynthetic process
741 GO:1901362 organic cyclic compound biosynthetic process
741 GO:0051252 regulation of RNA metabolic process
741 GO:0010468 regulation of gene expression
834 GO:0051252 regulation of RNA metabolic process
834 GO:2000112 regulation of cellular macromolecule biosynthetic process
834 GO:0010468 regulation of gene expression
834 GO:0006351 transcription, DNA-templated
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
31 GO:0005634 nucleus
47 GO:0005654 nucleoplasm
70 GO:0005654 nucleoplasm
80 GO:0005634 nucleus
127 GO:0005634 nucleus
160 GO:0005634 nucleus
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
191 GO:0031981 nuclear lumen
259 GO:0005886 plasma membrane
294 GO:0030529 intracellular ribonucleoprotein complex
294 GO:0005654 nucleoplasm
353 GO:0005654 nucleoplasm
379 GO:0005829 cytosol
379 GO:0005576 extracellular region
379 GO:0005634 nucleus
426 GO:0005654 nucleoplasm
464 GO:0070013 intracellular organelle lumen
464 GO:0005634 nucleus
478 GO:0005634 nucleus
591 GO:0031981 nuclear lumen
649 GO:0070013 intracellular organelle lumen
649 GO:0005634 nucleus
654 GO:0005654 nucleoplasm
681 GO:0005654 nucleoplasm
715 GO:0031981 nuclear lumen
741 GO:0031981 nuclear lumen
834 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome TAS
GO:0006366 transcription from RNA polymerase II promoter IEA
GO:0006396 RNA processing TAS
GO:0007165 signal transduction TAS
GO:0010988 regulation of low-density lipoprotein particle clearance IMP
GO:0016032 viral process IEA
GO:0016070 RNA metabolic process TAS
GO:0043066 negative regulation of apoptotic process IMP
GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process IMP
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP
GO:0048025 negative regulation of mRNA splicing, via spliceosome IEA
GO:0048260 positive regulation of receptor-mediated endocytosis IMP
GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter IMP
GO:1902165 regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000790 nuclear chromatin IDA
GO:0002102 podosome IEA
GO:0005634 nucleus TAS
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IEA
GO:0005925 focal adhesion IDA
GO:0016020 membrane IDA
GO:0031012 extracellular matrix IDA
GO:0042995 cell projection IEA
GO:0070062 extracellular exosome IDA
GO:0071013 catalytic step 2 spliceosome IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000790 nuclear chromatin GO:0005737 cytoplasm 4.55e-08 5.17e-23
GO:0000790 nuclear chromatin GO:0016020 membrane 3.99e-39 3.29e-131
GO:0005634 nucleus GO:0016020 membrane 0.00e+00 4.39e-236
GO:0005634 nucleus GO:0031012 extracellular matrix 1.58e-13 4.18e-03
GO:0005634 nucleus GO:0042995 cell projection 1.26e-06 3.17e-18
GO:0005634 nucleus GO:0070062 extracellular exosome 6.30e-13 4.54e-26
GO:0005654 nucleoplasm GO:0016020 membrane 5.76e-255 1.32e-206
GO:0005654 nucleoplasm GO:0031012 extracellular matrix 2.78e-09 4.74e-33
GO:0005654 nucleoplasm GO:0042995 cell projection 1.49e-18 8.51e-113
GO:0005654 nucleoplasm GO:0070062 extracellular exosome 3.37e-20 1.23e-35
Interactor Also a MoonDB EMF protein
PRP31_HUMAN No
ZN526_HUMAN No
ZN408_HUMAN No
VINEX_HUMAN No
ABI2_HUMAN Yes: Q9NYB9 (MoonDB)
AES_HUMAN Yes: Q08117 (MoonDB)
NPDC1_HUMAN No
KHDR3_HUMAN No
KHDR2_HUMAN No
ABC3C_HUMAN No
RBPS2_HUMAN No
NCK2_HUMAN Yes: O43639 (MoonDB)
Z385C_HUMAN No
MYPOP_HUMAN No
Q8N4W5_HUMAN No
RFOX2_HUMAN No
RAM_HUMAN No
GOR_HUMAN No
Q8IVT4_HUMAN No
G3V1X1_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
RBM7_HUMAN No
HBAZ_HUMAN No
TYK2_HUMAN No
RTP5_HUMAN No
ZN792_HUMAN No
Q8N9J2_HUMAN No
CNNM3_HUMAN No
DOCK2_HUMAN No
PCDBE_HUMAN No
RBMX_HUMAN No
RBY1F_HUMAN No
ANR28_HUMAN No
ODF3B_HUMAN No
DALD3_HUMAN No
FX4L3_HUMAN No
ZN575_HUMAN No
CQ055_HUMAN No
TMM8A_HUMAN No
FX4L1_HUMAN No
EKI2_HUMAN No
SPG7_HUMAN No
RASD1_HUMAN No
A0A024R857_HUMAN No
ABEC1_HUMAN No
ABI1_HUMAN No
ANM1_HUMAN No
AQP5_HUMAN No
AURKA_HUMAN No
CCAR1_HUMAN No
CCD33_HUMAN No
CDN1A_HUMAN Yes: P38936 (MoonDB)
CF226_HUMAN No
CIRBP_HUMAN No
CKLF5_HUMAN No
CQ113_HUMAN No
CTBL1_HUMAN No
DDX17_HUMAN No
DDX5_HUMAN No
DHX9_HUMAN No
DIDO1_HUMAN No
ELAV1_HUMAN No
FBW1A_HUMAN No
GFI1B_HUMAN No
GRAP2_HUMAN No
HNRLL_HUMAN No
HNRPD_HUMAN Yes: Q14103 (MoonDB)
HNRPL_HUMAN No
HNRPQ_HUMAN No
IIGP5_HUMAN No
ITSN2_HUMAN No
KCTD8_HUMAN No
KHDR1_HUMAN No
MARK4_HUMAN No
MATR3_HUMAN No
MISP_HUMAN No
MP2K2_HUMAN No
PABP1_HUMAN Yes: P11940 (MoonDB)
PCBP1_HUMAN No
PCBP2_HUMAN No
PELI2_HUMAN No
PRR3_HUMAN No
PTBP1_HUMAN No
Q6IPE9_HUMAN No
Q6NYL1_HUMAN No
Q96D16_HUMAN No
QKI_HUMAN No
RALY_HUMAN No
RASL3_HUMAN No
RBM10_HUMAN Yes: P98175 (MoonDB)
RBM3_HUMAN No
RBM41_HUMAN No
RBM42_HUMAN No
RBM4_HUMAN Yes: Q9BWF3 (MoonDB)
RBY1A_HUMAN No
RM09_HUMAN No
ROA0_HUMAN No
RPH3L_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
SMAD3_HUMAN Yes: P84022 (MoonDB)
SNRPA_HUMAN No
SRC_HUMAN Yes: P12931 (MoonDB)
SRRT_HUMAN No
SRSF3_HUMAN No
TE2IP_HUMAN No
TY3H_HUMAN No
U2AF1_HUMAN No
U2AF2_HUMAN No
UBC9_HUMAN Yes: P63279 (MoonDB)
YTDC1_HUMAN No
ZC3H1_HUMAN No
PMID Article Title
1729596 Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein.
8107114 Identification, molecular cloning, expression and chromosome mapping of a family of transformation upregulated hnRNP-K proteins derived by alternative splicing.
9651361 Hepatitis C virus core protein interacts with heterogeneous nuclear ribonucleoprotein K.
10369774 High precision solution structure of the C-terminal KH domain of heterogeneous nuclear ribonucleoprotein K, a c-myc transcription factor.
11840567 Cluster analysis of an extensive human breast cancer cell line protein expression map database.
11991638 Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis.
12093748 Molecular basis of sequence-specific single-stranded DNA recognition by KH domains: solution structure of a complex between hnRNP K KH3 and single-stranded DNA.
12183465 An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15164053 DNA sequence and analysis of human chromosome 9.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16360036 hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage.
16564677 PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17924679 Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18775702 African swine fever virus protein p30 interaction with heterogeneous nuclear ribonucleoprotein K (hnRNP-K) during infection.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20673990 A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22721921 Proteomic analysis of podosome fractions from macrophages reveals similarities to spreading initiation centres.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
22825850 DNA damage-induced heterogeneous nuclear ribonucleoprotein K SUMOylation regulates p53 transcriptional activation.
22967762 Characterization of O-GlcNAc cycling and proteomic identification of differentially O-GlcNAcylated proteins during G1/S transition.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25114211 Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.
25218447 Uncovering global SUMOylation signaling networks in a site-specific manner.
25755297 System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
25944712 N-terminome analysis of the human mitochondrial proteome.
26173930 GeneMatcher aids in the identification of a new malformation syndrome with intellectual disability, unique facial dysmorphisms, and skeletal and connective tissue abnormalities caused by de novo variants in HNRNPK.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
616580 Au-Kline syndrome
Domain Name Domain ID Source
KH_dom IPR004087 InterPro
KH_dom_type_1 IPR004088 InterPro
ROK_N IPR012987 InterPro
hnRNP_K IPR033090 InterPro
KH_dom_type_1_sf IPR036612 InterPro
KH_1 PF00013 Pfam
ROKNT PF08067 Pfam
KH_TYPE_1 PS50084 PROSITE
PTHR10288:SF221 PTHR10288:SF221 PANTHER
S43363 S43363 PIR
KH SM00322 SMART
SSF54791 SSF54791 SUPFAM