Protein: Q06124

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q06124 (Uniprot) PTN11_HUMAN PTPN11 Tyrosine-protein phosphatase non-receptor type 11 human No
Uniprot: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 35, 180 GO:0007165 signal transduction 355, 187 4.22e-144 6.90e-18
GO:0007165 signal transduction 187, 355 GO:0006139 nucleobase-containing compound metabolic process 572 1.10e-111 5.07e-25
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
180 GO:0044271 cellular nitrogen compound biosynthetic process
180 GO:0070887 cellular response to chemical stimulus
180 GO:0006139 nucleobase-containing compound metabolic process
180 GO:0031325 positive regulation of cellular metabolic process
180 GO:0010604 positive regulation of macromolecule metabolic process
180 GO:2000112 regulation of cellular macromolecule biosynthetic process
180 GO:0010468 regulation of gene expression
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
247 GO:0006464 cellular protein modification process
247 GO:0060255 regulation of macromolecule metabolic process
247 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
572 GO:0090304 nucleic acid metabolic process
573 GO:0006464 cellular protein modification process
573 GO:0006139 nucleobase-containing compound metabolic process
573 GO:0060255 regulation of macromolecule metabolic process
573 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
180 GO:0005829 cytosol
180 GO:0070013 intracellular organelle lumen
180 GO:0044428 nuclear part
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
247 GO:0005634 nucleus
355 GO:0044459 plasma membrane part
572 GO:0005634 nucleus
573 GO:0005829 cytosol
573 GO:0012505 endomembrane system
573 GO:0070013 intracellular organelle lumen
573 GO:0044428 nuclear part
573 GO:0031982 vesicle
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000077 DNA damage checkpoint IEA
GO:0000187 activation of MAPK activity IEA
GO:0006641 triglyceride metabolic process IEA
GO:0007173 epidermal growth factor receptor signaling pathway TAS
GO:0007229 integrin-mediated signaling pathway IEA
GO:0007411 axon guidance TAS
GO:0007420 brain development IMP
GO:0007507 heart development IMP
GO:0008543 fibroblast growth factor receptor signaling pathway TAS
GO:0009755 hormone-mediated signaling pathway IEA
GO:0021697 cerebellar cortex formation IEA
GO:0030168 platelet activation TAS
GO:0030220 platelet formation IEA
GO:0031295 T cell costimulation TAS
GO:0032528 microvillus organization IEA
GO:0033277 abortive mitotic cell cycle IEA
GO:0033628 regulation of cell adhesion mediated by integrin IMP
GO:0033629 negative regulation of cell adhesion mediated by integrin IEA
GO:0035264 multicellular organism growth IEA
GO:0035265 organ growth IEA
GO:0035335 peptidyl-tyrosine dephosphorylation IMP
GO:0035855 megakaryocyte development IEA
GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process IEA
GO:0036302 atrioventricular canal development IMP
GO:0038127 ERBB signaling pathway IDA
GO:0040014 regulation of multicellular organism growth IEA
GO:0042445 hormone metabolic process IEA
GO:0042593 glucose homeostasis IEA
GO:0043254 regulation of protein complex assembly IDA
GO:0045931 positive regulation of mitotic cell cycle IEA
GO:0046676 negative regulation of insulin secretion IEA
GO:0046825 regulation of protein export from nucleus IEA
GO:0046854 phosphatidylinositol phosphorylation IEA
GO:0046887 positive regulation of hormone secretion IEA
GO:0048008 platelet-derived growth factor receptor signaling pathway IEA
GO:0048011 neurotrophin TRK receptor signaling pathway IEA
GO:0048013 ephrin receptor signaling pathway IDA
GO:0048609 multicellular organismal reproductive process IEA
GO:0048806 genitalia development IMP
GO:0048839 inner ear development IMP
GO:0048873 homeostasis of number of cells within a tissue IEA
GO:0050900 leukocyte migration TAS
GO:0051463 negative regulation of cortisol secretion IEA
GO:0051897 positive regulation of protein kinase B signaling TAS
GO:0060020 Bergmann glial cell differentiation IEA
GO:0060125 negative regulation of growth hormone secretion IEA
GO:0060325 face morphogenesis IMP
GO:0060338 regulation of type I interferon-mediated signaling pathway TAS
GO:0061582 intestinal epithelial cell migration IEA
GO:0070374 positive regulation of ERK1 and ERK2 cascade IMP
GO:0071260 cellular response to mechanical stimulus IEA
GO:0071364 cellular response to epidermal growth factor stimulus IMP
GO:2001275 positive regulation of glucose import in response to insulin stimulus IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005739 mitochondrion IEA
GO:0005829 cytosol TAS
GO:0043234 protein complex IMP
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1280823 Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.
1281790 Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.
7681217 Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation.
7681589 A widely expressed human protein-tyrosine phosphatase containing src homology 2 domains.
7691811 Activation of the SH2-containing phosphotyrosine phosphatase SH-PTP2 by its binding site, phosphotyrosine 1009, on the human platelet-derived growth factor receptor.
8041791 Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras.
8216283 Cloning, expression and mutational analysis of SH-PTP2, human protein-tyrosine phosphatase.
8810330 Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule.
9062191 A family of proteins that inhibit signalling through tyrosine kinase receptors.
9491886 Crystal structure of the tyrosine phosphatase SHP-2.
9600074 Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.
10068651 Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors.
10209036 SHP2-interacting transmembrane adaptor protein (SIT), a novel disulfide-linked dimer regulating human T-cell activation.
10655584 Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation.
10681522 Dissecting the interaction of SHP-2 with PZR, an immunoglobulin family protein containing immunoreceptor tyrosine-based inhibitory motifs.
11162587 Molecular cloning and characterization of SPAP1, an inhibitory receptor.
11389028 Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
11414741 Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
11433379 Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein).
11704759 Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome.
11992261 PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype-phenotype correlation, and phenotypic heterogeneity.
12058348 Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene.
12161469 PTPN11 (protein-tyrosine phosphatase, nonreceptor-type 11) mutations in seven Japanese patients with Noonan syndrome.
12325025 PTPN11 mutations in Noonan syndrome type I: detection of recurrent mutations in exons 3 and 13.
12529711 PTPN11 mutation in a large family with Noonan syndrome and dizygous twinning.
12634870 Spectrum of mutations in PTPN11 and genotype-phenotype correlation in 96 patients with Noonan syndrome and five patients with cardio-facio-cutaneous syndrome.
12717436 Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndromes and acute myeloid leukemia.
12739139 Noonan syndrome with leukaemoid reaction and overproduction of catecholamines: a case report.
12960218 Correlation between PTPN11 gene mutations and congenital heart defects in Noonan and LEOPARD syndromes.
12972546 Identification of Fer tyrosine kinase localized on microtubules as a platelet endothelial cell adhesion molecule-1 phosphorylating kinase in vascular endothelial cells.
14597715 The inhibitory potential of Fc receptor homolog 4 on memory B cells.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14961557 A novel PTPN11 mutation in LEOPARD syndrome.
15102829 Activation of vascular endothelial growth factor receptor-3 and its downstream signaling promote cell survival under oxidative stress.
15121796 Clinical and molecular analysis of 30 patients with multiple lentigines LEOPARD syndrome.
15384080 Clinical variability in a Noonan syndrome family with a new PTPN11 gene mutation.
15389709 Two novel and one recurrent PTPN11 mutations in LEOPARD syndrome.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15520399 PTPN11 mutations in patients with LEOPARD syndrome: a French multicentric experience.
15526160 Signal transduction via the stem cell factor receptor/c-Kit.
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15690106 Genetic heterogeneity in LEOPARD syndrome: two families with no mutations in PTPN11.
15889278 A novel mutation in the PTPN11 gene in a patient with Noonan syndrome and rapidly progressive hypertrophic cardiomyopathy.
15948193 Neurofibromatosis-Noonan syndrome: molecular evidence of the concurrence of both disorders in a patient.
16679933 Acute myelomonocytic leukemia in a boy with LEOPARD syndrome (PTPN11 gene mutation positive).
16733669 PTPN11 gene mutations: linking the Gln510Glu mutation to the 'LEOPARD syndrome phenotype'.
16885344 ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.
16956752 ANKHD1, ankyrin repeat and KH domain containing 1, is overexpressed in acute leukemias and is associated with SHP2 in K562 cells.
17213291 FcRL6, a new ITIM-bearing receptor on cytolytic cells, is broadly expressed by lymphocytes following HIV-1 infection.
18559669 Regulation of RhoA-dependent ROCKII activation by Shp2.
18604210 An essential function for beta-arrestin 2 in the inhibitory signaling of natural killer cells.
18829466 Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.
19020799 PTPN11, SOS1, KRAS, and RAF1 gene analysis, and genotype-phenotype correlation in Korean patients with Noonan syndrome.
19167335 Large-scale structural analysis of the classical human protein tyrosine phosphatome.
19342684 A novel and critical role for tyrosine 663 in platelet endothelial cell adhesion molecule-1 trafficking and transendothelial migration.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19509291 GAREM, a novel adaptor protein for growth factor receptor-bound protein 2, contributes to cellular transformation through the activation of extracellular signal-regulated kinase signaling.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19843936 FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20170098 Salicylic acid based small molecule inhibitor for the oncogenic Src homology-2 domain containing protein tyrosine phosphatase-2 (SHP2).
20494825 Mutation of tyrosine residue 857 in the PDGF beta-receptor affects cell proliferation but not migration.
20577567 Whole-genome sequencing of a single proband together with linkage analysis identifies a Mendelian disease gene.
21269460 Initial characterization of the human central proteome.
23112346 Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
24891296 A PTPN11 allele encoding a catalytically impaired SHP2 protein in a patient with a Noonan syndrome phenotype.
26742426 Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling.
28074573 Structural, Functional, and Clinical Characterization of a Novel PTPN11 Mutation Cluster Underlying Noonan Syndrome.
OMIM ID Disease Name
151100 LEOPARD syndrome 1
156250 Metachondromatosis
163950 Noonan syndrome 1
607785 Leukemia, juvenile myelomonocytic
Domain Name Domain ID Source
PTPase_domain IPR000242 InterPro
TYR_PHOSPHATASE_dom IPR000387 InterPro
SH2 IPR000980 InterPro
Tyr_Pase_cat IPR003595 InterPro
Tyr_Pase_non-rcpt_typ-6/11 IPR012152 InterPro
Tyr_Pase_AS IPR016130 InterPro
Prot-tyrosine_phosphatase-like IPR029021 InterPro
SH2_dom_sf IPR036860 InterPro
JN0805 JN0805 PIR
SH2 PF00017 Pfam
Y_phosphatase PF00102 Pfam
Tyr-Ptase_nr_6 PIRSF000929 PIRSF
SH2DOMAIN PR00401 PRINTS
PRTYPHPHTASE PR00700 PRINTS
TYR_PHOSPHATASE_1 PS00383 PROSITE
SH2 PS50001 PROSITE
TYR_PHOSPHATASE_PTP PS50055 PROSITE
TYR_PHOSPHATASE_2 PS50056 PROSITE
PTPc SM00194 SMART
SH2 SM00252 SMART
PTPc_motif SM00404 SMART
SSF52799 SSF52799 SUPFAM
SSF55550 SSF55550 SUPFAM