Protein: Q9NR28

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9NR28 (Uniprot) DBLOH_HUMAN DIABLO Diablo homolog, mitochondrial human No
Uniprot: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 270 6.37e-04 1.88e-40
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
270 GO:0034645 cellular macromolecule biosynthetic process
270 GO:0010467 gene expression
270 GO:0090304 nucleic acid metabolic process
270 GO:0032446 protein modification by small protein conjugation
270 GO:0060255 regulation of macromolecule metabolic process
270 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
125 GO:0005829 cytosol
125 GO:0005634 nucleus
176 GO:0016021 integral component of membrane
176 GO:0031090 organelle membrane
270 GO:0005829 cytosol
270 GO:0070013 intracellular organelle lumen
270 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process TAS
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process TAS
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors TAS
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress IEA
GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IEA
GO:0043065 positive regulation of apoptotic process TAS
GO:0051402 neuron apoptotic process IEA
GO:0097193 intrinsic apoptotic signaling pathway TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005739 mitochondrion IDA
GO:0005758 mitochondrial intermembrane space TAS
GO:0005829 cytosol TAS
GO:0009898 cytoplasmic side of plasma membrane ISS
GO:0035631 CD40 receptor complex ISS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10929711 Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
10950947 Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
10972280 Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
11140637 Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
14523016 Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15200957 Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075 The finished DNA sequence of human chromosome 12.
16729033 Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.
21269460 Initial characterization of the human central proteome.
21536684 Survivin monomer plays an essential role in apoptosis regulation.
21722859 Functional mutation of SMAC/DIABLO, encoding a mitochondrial proapoptotic protein, causes human progressive hearing loss DFNA64.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
OMIM ID Disease Name
614152 Deafness, autosomal dominant, 64
Domain Name Domain ID Source
Smac/DIABLO-like_sf IPR009062 InterPro
Smac_DIABLO IPR015142 InterPro
Smac_DIABLO PF09057 Pfam
SSF46984 SSF46984 SUPFAM