Protein: Q9NR28 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9NR28 (Uniprot)	DBLOH_HUMAN	DIABLO	Diablo homolog, mitochondrial	human	No

Protein Function

Uniprot: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis-inhibiting activit more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0009056	catabolic process	125	GO:0009059	macromolecule biosynthetic process	270	6.37e-04	1.88e-40

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MoonDB Network Modules

Biological Processes

Showing 1 to 9 of 9 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
125	GO:0044248	cellular catabolic process
125	GO:0016567	protein ubiquitination
125	GO:0060255	regulation of macromolecule metabolic process
270	GO:0034645	cellular macromolecule biosynthetic process
270	GO:0010467	gene expression
270	GO:0090304	nucleic acid metabolic process
270	GO:0032446	protein modification by small protein conjugation
270	GO:0060255	regulation of macromolecule metabolic process
270	GO:0007165	signal transduction

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
125	GO:0005829	cytosol
125	GO:0005634	nucleus
176	GO:0016021	integral component of membrane
176	GO:0031090	organelle membrane
270	GO:0005829	cytosol
270	GO:0070013	intracellular organelle lumen
270	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006915	apoptotic process	TAS
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	TAS
GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors	TAS
GO:0008631	intrinsic apoptotic signaling pathway in response to oxidative stress	IEA
GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c	IEA
GO:0043065	positive regulation of apoptotic process	TAS
GO:0051402	neuron apoptotic process	IEA
GO:0097193	intrinsic apoptotic signaling pathway	TAS

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Cellular Components

Showing 1 to 5 of 5 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005739	mitochondrion	IDA
GO:0005758	mitochondrial intermembrane space	TAS
GO:0005829	cytosol	TAS
GO:0009898	cytoplasmic side of plasma membrane	ISS
GO:0035631	CD40 receptor complex	ISS

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
AR6P1_HUMAN	No
ARNT_HUMAN	Yes: P27540 (MoonDB)
ATRAP_HUMAN	No
BIRC2_HUMAN	No
BIRC5_HUMAN	No
BIRC7_HUMAN	No
BIRC8_HUMAN	No
DERL2_HUMAN	No
DG2L6_HUMAN	No
EF1A1_HUMAN	No

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Publications Associated

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PMID	Article Title
10929711	Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition.
10950947	Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway.
10972280	Structural and biochemical basis of apoptotic activation by Smac/DIABLO.
11140637	Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
14523016	Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15200957	Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase.
15489334	The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16541075	The finished DNA sequence of human chromosome 12.
16729033	Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway.

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OMIM Diseases Associated

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OMIM ID	Disease Name
614152	Deafness, autosomal dominant, 64

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Protein Domains Associated

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Domain Name	Domain ID	Source
PTHR32247	PTHR32247	PANTHER
Smac/DIABLO-like_sf	IPR009062	InterPro
Smac_DIABLO	IPR015142	InterPro
Smac_DIABLO	PF09057	Pfam
SSF46984	SSF46984	SUPFAM

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