Protein: P27540

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P27540 (Uniprot) ARNT_HUMAN ARNT Aryl hydrocarbon receptor nuclear translocator human No
Uniprot: Required for activity of the Ah (dioxin) receptor. This protein is required for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. The heterodimer with HIF1A or EPAS1/HIF2A functions as a transcriptional regulator of the adaptive response to hypoxia. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006725 cellular aromatic compound metabolic process 152 GO:0007165 signal transduction 169 5.44e-126 5.27e-27
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
152 GO:0006139 nucleobase-containing compound metabolic process
169 GO:0030522 intracellular receptor signaling pathway
169 GO:0045892 negative regulation of transcription, DNA-templated
169 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
169 GO:0043401 steroid hormone mediated signaling pathway
471 GO:0034645 cellular macromolecule biosynthetic process
471 GO:0044271 cellular nitrogen compound biosynthetic process
471 GO:0006464 cellular protein modification process
471 GO:0031324 negative regulation of cellular metabolic process
471 GO:0010605 negative regulation of macromolecule metabolic process
471 GO:0010604 positive regulation of macromolecule metabolic process
471 GO:0051173 positive regulation of nitrogen compound metabolic process
471 GO:0051252 regulation of RNA metabolic process
471 GO:0010468 regulation of gene expression
471 GO:0007165 signal transduction
632 GO:0010467 gene expression
632 GO:0090304 nucleic acid metabolic process
632 GO:0060255 regulation of macromolecule metabolic process
632 GO:0007165 signal transduction
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
152 GO:0005829 cytosol
152 GO:0005634 nucleus
169 GO:0005654 nucleoplasm
471 GO:0005654 nucleoplasm
632 GO:0031981 nuclear lumen
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001666 response to hypoxia IDA
GO:0001892 embryonic placenta development IEA
GO:0001938 positive regulation of endothelial cell proliferation IC
GO:0006351 transcription, DNA-templated TAS
GO:0006805 xenobiotic metabolic process TAS
GO:0010575 positive regulation of vascular endothelial growth factor production IDA
GO:0030154 cell differentiation IEA
GO:0030522 intracellular receptor signaling pathway IEA
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway IC
GO:0033235 positive regulation of protein sumoylation IEA
GO:0042789 mRNA transcription from RNA polymerase II promoter IC
GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress IDA
GO:0045648 positive regulation of erythrocyte differentiation IC
GO:0045821 positive regulation of glycolytic process IC
GO:0045893 positive regulation of transcription, DNA-templated IDA
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA
GO:0046886 positive regulation of hormone biosynthetic process IDA
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IEA
GO:0016604 nuclear body IDA
GO:0090575 RNA polymerase II transcription factor complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
1317062 Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor.
1852076 Cloning of a factor required for activity of the Ah (dioxin) receptor.
7539918 Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.
8621524 Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions.
10395741 Interactions of nuclear receptor coactivator/corepressor proteins with the aryl hydrocarbon receptor complex.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
16710414 The DNA sequence and biological annotation of human chromosome 1.
18669648 A quantitative atlas of mitotic phosphorylation.
20699359 Casein kinase 1 regulates human hypoxia-inducible factor HIF-1.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
No results found.
Domain Name Domain ID Source
I59550 I59550 PIR
PAS IPR000014 InterPro
Nuc_translocat IPR001067 InterPro
PAC IPR001610 InterPro
bHLH_dom IPR011598 InterPro
PAS_fold IPR013767 InterPro
PAS-like_dom_sf IPR035965 InterPro
HLH_DNA-bd_sf IPR036638 InterPro
HLH PF00010 Pfam
PAS PF00989 Pfam
NCTRNSLOCATR PR00785 PRINTS
PAS PS50112 PROSITE
BHLH PS50888 PROSITE
PAC SM00086 SMART
PAS SM00091 SMART
HLH SM00353 SMART
SSF47459 SSF47459 SUPFAM
SSF55785 SSF55785 SUPFAM
sensory_box TIGR00229 TIGRFAMs
HLH cd00083 CDD
PAS cd00130 CDD