Protein: P07359 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P07359 (Uniprot)	GP1BA_HUMAN	GP1BA	Platelet glycoprotein Ib alpha chain	human	No

Protein Function

Uniprot: GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0044260	cellular macromolecule metabolic process	429	GO:0033036	macromolecule localization	517	4.56e-06	3.25e-28

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
306	GO:0044267	cellular protein metabolic process
306	GO:0060255	regulation of macromolecule metabolic process
306	GO:0007165	signal transduction
429	GO:0016070	RNA metabolic process
429	GO:0034645	cellular macromolecule biosynthetic process
429	GO:0044271	cellular nitrogen compound biosynthetic process
429	GO:0019538	protein metabolic process
429	GO:0010468	regulation of gene expression
429	GO:0010556	regulation of macromolecule biosynthetic process
429	GO:0019219	regulation of nucleobase-containing compound metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
306	GO:0070062	extracellular exosome
429	GO:0070013	intracellular organelle lumen
429	GO:0005634	nucleus
517	GO:0005829	cytosol
517	GO:0012505	endomembrane system
517	GO:0031982	vesicle

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000902	cell morphogenesis	IEA
GO:0006469	negative regulation of protein kinase activity	IBA
GO:0007155	cell adhesion	IDA
GO:0007166	cell surface receptor signaling pathway	TAS
GO:0007596	blood coagulation	TAS
GO:0007597	blood coagulation, intrinsic pathway	TAS
GO:0019221	cytokine-mediated signaling pathway	IBA
GO:0030168	platelet activation	TAS
GO:0030193	regulation of blood coagulation	TAS
GO:0042730	fibrinolysis	IDA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005737	cytoplasm	IBA
GO:0005886	plasma membrane	TAS
GO:0005887	integral component of plasma membrane	TAS
GO:0009986	cell surface	IDA
GO:0016020	membrane	IDA
GO:0031362	anchored component of external side of plasma membrane	IDA
GO:0070062	extracellular exosome	IDA

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005737	cytoplasm	GO:0005887	integral component of plasma membrane	4.51e-73	1.63e-08

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433Z_HUMAN	Yes: P63104 (MoonDB)
DDIT3_HUMAN	No
FA12_HUMAN	No
FLNA_HUMAN	Yes: P21333 (MoonDB)
FLNB_HUMAN	No
GP1BB_HUMAN	No
GPIX_HUMAN	No
THRB_HUMAN	Yes: P00734 (MoonDB)
VWF_HUMAN	No

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Publications Associated

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PMID	Article Title
1577776	Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications.
1586750	Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness.
1730088	Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease.
2052556	Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease.
2070794	Identification of the disulphide bonds in human platelet glycocalicin.
2845978	Structure of the human blood platelet membrane glycoprotein Ib alpha gene.
3303030	Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein.
3497398	Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib.
7632942	The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145.
7690774	Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome.

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OMIM Diseases Associated

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OMIM ID	Disease Name
153670	Bernard-Soulier syndrome A2, autosomal dominant
177820	Pseudo-von Willebrand disease
231200	Bernard-Soulier syndrome
258660	Non-arteritic anterior ischemic optic neuropathy

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Protein Domains Associated

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Domain Name	Domain ID	Source
Cys-rich_flank_reg_C	IPR000483	InterPro
I70082	I70082	PIR
Leu-rich_rpt	IPR001611	InterPro
Leu-rich_rpt_typical-subtyp	IPR003591	InterPro
LRR	PS51450	PROSITE
LRR_8	PF13855	Pfam
LRR_dom_sf	IPR032675	InterPro
LRR_TYP	SM00369	SMART
LRRCT	SM00082	SMART
LRRNT	IPR000372	InterPro

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