Protein: P12956 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P12956 (Uniprot)	XRCC6_HUMAN	XRCC6	X-ray repair cross-complementing protein 6	human	Yes

Protein Function

Uniprot: Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-ho more..

Dissimilar Functions Manual Curation

Function 1: DNA repair (NHEJ).

Function 2: Telomere maintainance in association with NARG1, the Ku p70/p86 dimer binds to the osteocalcin promoter and activates osteocalcin expression.

Publications (PMID): 12145306

MoonDB Network Modules

Biological Processes

Showing 1 to 10 of 79 entries

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Module ID (MoonGO)	GO ID (BP)	GO Name
51	GO:0060255	regulation of macromolecule metabolic process
107	GO:0016070	RNA metabolic process
107	GO:0044267	cellular protein metabolic process
107	GO:0034654	nucleobase-containing compound biosynthetic process
107	GO:2000112	regulation of cellular macromolecule biosynthetic process
107	GO:0010468	regulation of gene expression
107	GO:0019219	regulation of nucleobase-containing compound metabolic process
107	GO:0007165	signal transduction
123	GO:0006464	cellular protein modification process
123	GO:0006355	regulation of transcription, DNA-templated

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
39	GO:0043232	intracellular non-membrane-bounded organelle
51	GO:0005634	nucleus
101	GO:0005829	cytosol
101	GO:0043232	intracellular non-membrane-bounded organelle
107	GO:0005829	cytosol
107	GO:0005654	nucleoplasm
123	GO:0043232	intracellular non-membrane-bounded organelle
123	GO:0005654	nucleoplasm
173	GO:0005654	nucleoplasm
181	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000723	telomere maintenance	TAS
GO:0002218	activation of innate immune response	IDA
GO:0006266	DNA ligation	TAS
GO:0006303	double-strand break repair via nonhomologous end joining	TAS
GO:0006310	DNA recombination	IEA
GO:0006351	transcription, DNA-templated	IEA
GO:0007420	brain development	IEA
GO:0032481	positive regulation of type I interferon production	TAS
GO:0032508	DNA duplex unwinding	IEA
GO:0043312	neutrophil degranulation	TAS

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0000783	nuclear telomere cap complex	TAS
GO:0000784	nuclear chromosome, telomeric region	IDA
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	TAS
GO:0005654	nucleoplasm	TAS
GO:0005667	transcription factor complex	IDA
GO:0005730	nucleolus	IDA
GO:0005829	cytosol	TAS
GO:0016020	membrane	IDA
GO:0032993	protein-DNA complex	IDA

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Dissimilar Cellular Components (PrOnto)

Showing 1 to 9 of 9 entries

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005654	nucleoplasm	6.62e-72	7.68e-98
GO:0005576	extracellular region	GO:0005667	transcription factor complex	2.39e-24	8.05e-200
GO:0005576	extracellular region	GO:0005730	nucleolus	6.04e-15	4.85e-05
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005654	nucleoplasm	GO:0016020	membrane	5.76e-255	1.32e-206
GO:0005667	transcription factor complex	GO:0016020	membrane	1.61e-58	1.75e-266
GO:0005730	nucleolus	GO:0016020	membrane	8.89e-46	1.83e-10
GO:0016020	membrane	GO:0032993	protein-DNA complex	3.22e-21	3.33e-35

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
1433Z_HUMAN	Yes: P63104 (MoonDB)
A0A0G2JPK4_HUMAN	No
ABCD4_HUMAN	No
ACD_HUMAN	Yes: Q96AP0 (MoonDB)
ADCY7_HUMAN	No
ANXA1_HUMAN	No
AP2C_HUMAN	No
APLF_HUMAN	No
ARAP1_HUMAN	No
ATP23_HUMAN	No

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Publications Associated

Showing 1 to 10 of 46 entries

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PMID	Article Title
1537839	Identification of proteins binding to interferon-inducible transcriptional enhancers in hematopoietic cells.
1608402	Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides.
2466842	Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen.
2917966	Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen.
7882982	Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.
7957065	Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.
8605992	Non-histone protein 1 (NHP1) is a member of the Ku protein family which is upregulated in differentiating mouse myoblasts and human promyelocytes.
8621488	The interaction between Ku antigen and REF1 protein mediates negative gene regulation by extracellular calcium.
9362500	Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.
9742108	Productive and nonproductive complexes of Ku and DNA-dependent protein kinase at DNA termini.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

Showing 1 to 10 of 23 entries

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Domain Name	Domain ID	Source
A30894	A30299	PIR
Ku	PF02735	Pfam
Ku70	IPR006165	InterPro
Ku70	PIRSF003033	PIRSF
ku70	TIGR00578	TIGRFAMs
Ku70/Ku80_beta-barrel_dom	IPR006164	InterPro
Ku70_bridge/pillars_dom_sf	IPR027388	InterPro
Ku78	SM00559	SMART
Ku_C	IPR005160	InterPro
Ku_C	PF03730	Pfam

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