Protein: Q9HAU5 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
Q9HAU5 (Uniprot)	RENT2_HUMAN	UPF2	Regulator of nonsense transcripts 2	human	No

Protein Function

Uniprot: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (i more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0019538	protein metabolic process	175	GO:0016070	RNA metabolic process	75	5.15e-08	2.82e-13

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
75	GO:0016071	mRNA metabolic process
75	GO:0051252	regulation of RNA metabolic process
75	GO:0010468	regulation of gene expression
75	GO:0006351	transcription, DNA-templated
152	GO:0006139	nucleobase-containing compound metabolic process
175	GO:0044267	cellular protein metabolic process
175	GO:0006139	nucleobase-containing compound metabolic process
175	GO:0010468	regulation of gene expression
310	GO:0019538	protein metabolic process
554	GO:0016070	RNA metabolic process

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
75	GO:0005829	cytosol
75	GO:0005654	nucleoplasm
136	GO:0005829	cytosol
136	GO:0005634	nucleus
152	GO:0005829	cytosol
152	GO:0005634	nucleus
175	GO:0005829	cytosol
175	GO:0005634	nucleus
291	GO:0043232	intracellular non-membrane-bounded organelle
291	GO:0005634	nucleus

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	TAS
GO:0001889	liver development	IEA
GO:0006406	mRNA export from nucleus	TAS
GO:0031100	animal organ regeneration	IEA

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Cellular Components

Showing 1 to 7 of 7 entries

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005844	polysome	IBA
GO:0035145	exon-exon junction complex	IDA
GO:0036464	cytoplasmic ribonucleoprotein granule	IDA
GO:0048471	perinuclear region of cytoplasm	IEA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ABCF2_HUMAN	No
AKTIP_HUMAN	No
AT1B3_HUMAN	No
BLM_HUMAN	No
CALR_HUMAN	No
CENPU_HUMAN	No
CIZ1_HUMAN	No
CMTD1_HUMAN	No
CY24A_HUMAN	No
DCP1B_HUMAN	No

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Publications Associated

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PMID	Article Title
10718198	Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
11073994	Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.
11113196	Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
11163187	Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
11544179	Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
11546874	Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
12554878	Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
14574404	The DNA sequence and analysis of human chromosome 6.
14702039	Complete sequencing and characterization of 21,243 full-length human cDNAs.
15004547	The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
ARM-type_fold	IPR016024	InterPro
MIF4G	PF02854	Pfam
MIF4G	SM00543	SMART
MIF4G-like_typ-3	IPR003890	InterPro
SSF48371	SSF48371	SUPFAM
T12507	T12507	PIR
Up-fram_suppressor-2	IPR007193	InterPro
Upf2	PF04050	Pfam

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