Protein: Q9HAU5

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q9HAU5 (Uniprot) RENT2_HUMAN UPF2 Regulator of nonsense transcripts 2 human No
Uniprot: Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 175 GO:0016070 RNA metabolic process 75 5.15e-08 2.82e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
75 GO:0016071 mRNA metabolic process
75 GO:0051252 regulation of RNA metabolic process
75 GO:0010468 regulation of gene expression
75 GO:0006351 transcription, DNA-templated
152 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0044267 cellular protein metabolic process
175 GO:0006139 nucleobase-containing compound metabolic process
175 GO:0010468 regulation of gene expression
310 GO:0019538 protein metabolic process
554 GO:0016070 RNA metabolic process
554 GO:0010468 regulation of gene expression
658 GO:0019538 protein metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
75 GO:0005829 cytosol
75 GO:0005654 nucleoplasm
136 GO:0005829 cytosol
136 GO:0005634 nucleus
152 GO:0005829 cytosol
152 GO:0005634 nucleus
175 GO:0005829 cytosol
175 GO:0005634 nucleus
291 GO:0043232 intracellular non-membrane-bounded organelle
291 GO:0005634 nucleus
310 GO:0005829 cytosol
310 GO:0005634 nucleus
332 GO:0005634 nucleus
417 GO:0005829 cytosol
417 GO:0043232 intracellular non-membrane-bounded organelle
554 GO:0005634 nucleus
658 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
GO:0001889 liver development IEA
GO:0006406 mRNA export from nucleus TAS
GO:0031100 animal organ regeneration IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005844 polysome IBA
GO:0035145 exon-exon junction complex IDA
GO:0036464 cytoplasmic ribonucleoprotein granule IDA
GO:0048471 perinuclear region of cytoplasm IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10718198 Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
11073994 Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes.
11113196 Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).
11163187 Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon.
11544179 Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay.
11546874 Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1.
12554878 Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1.
14574404 The DNA sequence and analysis of human chromosome 6.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15004547 The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16209946 Exon-junction complex components specify distinct routes of nonsense-mediated mRNA decay with differential cofactor requirements.
16452507 Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.
17974005 The full-ORF clone resource of the German cDNA consortium.
18066079 NMD factors UPF2 and UPF3 bridge UPF1 to the exon junction complex and stimulate its RNA helicase activity.
19556969 Unusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
MIF4G-like_typ-3 IPR003890 InterPro
Up-fram_suppressor-2 IPR007193 InterPro
ARM-type_fold IPR016024 InterPro
MIF4G PF02854 Pfam
Upf2 PF04050 Pfam
MIF4G SM00543 SMART
SSF48371 SSF48371 SUPFAM
T12507 T12507 PIR