Protein: P29350 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P29350 (Uniprot)	PTN6_HUMAN	PTPN6	Tyrosine-protein phosphatase non-receptor type 6	human	No

Protein Function

Uniprot: Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimu more..

MoonDB Dissimilar Functions

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GO ID 1	Function 1	Module ID 1	GO ID 2	Function 2	Module ID 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0007165	signal transduction	355	GO:0034641	cellular nitrogen compound metabolic process	786	4.22e-144	6.90e-18

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MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
111	GO:0006955	immune response
111	GO:0035556	intracellular signal transduction
111	GO:0009967	positive regulation of signal transduction
111	GO:0006468	protein phosphorylation
111	GO:0060255	regulation of macromolecule metabolic process
111	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway
355	GO:0007166	cell surface receptor signaling pathway
355	GO:0006464	cellular protein modification process
355	GO:0035556	intracellular signal transduction
355	GO:0016310	phosphorylation

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
111	GO:0005829	cytosol
111	GO:0005886	plasma membrane
117	GO:0005634	nucleus
355	GO:0044459	plasma membrane part
573	GO:0005829	cytosol
573	GO:0012505	endomembrane system
573	GO:0070013	intracellular organelle lumen
573	GO:0044428	nuclear part
573	GO:0031982	vesicle
786	GO:0005829	cytosol

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0002244	hematopoietic progenitor cell differentiation	IEA
GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin	IEA
GO:0006470	protein dephosphorylation	IDA
GO:0006915	apoptotic process	TAS
GO:0007186	G-protein coupled receptor signaling pathway	TAS
GO:0008283	cell proliferation	IDA
GO:0008284	positive regulation of cell proliferation	IMP
GO:0008285	negative regulation of cell proliferation	NAS
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	IMP
GO:0018108	peptidyl-tyrosine phosphorylation	IDA

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IDA
GO:0005730	nucleolus	IDA
GO:0005737	cytoplasm	IDA
GO:0005829	cytosol	TAS
GO:0005911	cell-cell junction	IEA
GO:0016020	membrane	TAS
GO:0035580	specific granule lumen	TAS
GO:0042105	alpha-beta T cell receptor complex	IEA
GO:0043234	protein complex	IMP

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Dissimilar Cellular Components (PrOnto)

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GO ID 1	Component 1	GO ID 2	Component 2	Association Probability (PrOnto)	Interaction Probability (PrOnto)
GO:0005576	extracellular region	GO:0005634	nucleus	4.48e-91	1.28e-107
GO:0005576	extracellular region	GO:0005730	nucleolus	6.04e-15	4.85e-05
GO:0005634	nucleus	GO:0016020	membrane	0.00e+00	4.39e-236
GO:0005634	nucleus	GO:0070062	extracellular exosome	6.30e-13	4.54e-26
GO:0005730	nucleolus	GO:0016020	membrane	8.89e-46	1.83e-10

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All Protein Interactions

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Interactor	Also a MoonDB EMF protein
3BP2_HUMAN	No
CADH2_HUMAN	No
ESR1_HUMAN	Yes: P03372 (MoonDB)
FAK1_HUMAN	No
FCG2B_HUMAN	No
FHL3_HUMAN	No
GRB2_HUMAN	Yes: P62993 (MoonDB)
KI2L3_HUMAN	No
LAIR1_HUMAN	No
LAT_HUMAN	No

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Publications Associated

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PMID	Article Title
1652101	A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases.
1732748	Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.
1736296	Isolation of a src homology 2-containing tyrosine phosphatase.
7665165	Human protein tyrosine phosphatase 1C (PTPN6) gene structure: alternate promoter usage and exon skipping generate multiple transcripts.
7781604	Tyrosine phosphorylation of an SH2-containing protein tyrosine phosphatase is coupled to platelet thrombin receptor via a pertussis toxin-sensitive heterotrimeric G-protein.
9074930	Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination.
9285411	A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules.
9712903	High expression of inhibitory receptor SHPS-1 and its association with protein tyrosine phosphatase SHP-1 in macrophages.
9774441	Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1.
9842885	The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
Prot-tyrosine_phosphatase-like	IPR029021	InterPro
PRTYPHPHTASE	PR00700	PRINTS
PTPase_domain	IPR000242	InterPro
PTPc	SM00194	SMART
PTPc_motif	SM00404	SMART
S20825	B42031	PIR
SH2	IPR000980	InterPro
SH2	PF00017	Pfam
SH2	PS50001	PROSITE
SH2	SM00252	SMART

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