Protein: P00519

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P00519 (Uniprot) ABL1_HUMAN ABL1 Tyrosine-protein kinase ABL1 human No
Uniprot: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0034641 cellular nitrogen compound metabolic process 35, 327, 492 GO:0007165 signal transduction 355 4.22e-144 6.90e-18
GO:0034641 cellular nitrogen compound metabolic process 35, 327, 492 GO:0006928 movement of cell or subcellular component 496 7.55e-40 5.63e-168
GO:0007166 cell surface receptor signaling pathway 108 GO:0034641 cellular nitrogen compound metabolic process 35, 327, 492 5.53e-55 9.57e-64
GO:0007166 cell surface receptor signaling pathway 108 GO:0009059 macromolecule biosynthetic process 682 2.49e-18 9.18e-29
GO:0007166 cell surface receptor signaling pathway 108 GO:0006139 nucleobase-containing compound metabolic process 698 6.88e-41 1.21e-84
GO:0007165 signal transduction 141, 187, 282, 355 GO:0006139 nucleobase-containing compound metabolic process 698 1.10e-111 5.07e-25
GO:0010646 regulation of cell communication 284 GO:0034641 cellular nitrogen compound metabolic process 35, 327, 492 1.59e-39 2.52e-03
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 698 6.71e-28 7.52e-07
GO:0006928 movement of cell or subcellular component 496 GO:0006139 nucleobase-containing compound metabolic process 698 1.95e-31 6.36e-195
Module ID (MoonGO) GO ID (BP) GO Name
20 GO:0019538 protein metabolic process
20 GO:0007165 signal transduction
35 GO:0044271 cellular nitrogen compound biosynthetic process
35 GO:0044267 cellular protein metabolic process
35 GO:0090304 nucleic acid metabolic process
35 GO:0010468 regulation of gene expression
35 GO:0009966 regulation of signal transduction
108 GO:0007167 enzyme linked receptor protein signaling pathway
108 GO:0006139 nucleobase-containing compound metabolic process
108 GO:0031325 positive regulation of cellular metabolic process
108 GO:1902533 positive regulation of intracellular signal transduction
108 GO:0010604 positive regulation of macromolecule metabolic process
108 GO:0006468 protein phosphorylation
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
141 GO:0035556 intracellular signal transduction
141 GO:0006468 protein phosphorylation
141 GO:0060255 regulation of macromolecule metabolic process
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
177 GO:0044267 cellular protein metabolic process
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
202 GO:0044267 cellular protein metabolic process
202 GO:0070887 cellular response to chemical stimulus
202 GO:0060255 regulation of macromolecule metabolic process
202 GO:0007165 signal transduction
205 GO:0071310 cellular response to organic substance
205 GO:0007167 enzyme linked receptor protein signaling pathway
205 GO:0090304 nucleic acid metabolic process
205 GO:0034654 nucleobase-containing compound biosynthetic process
205 GO:0043085 positive regulation of catalytic activity
205 GO:0031325 positive regulation of cellular metabolic process
205 GO:0010604 positive regulation of macromolecule metabolic process
205 GO:0051173 positive regulation of nitrogen compound metabolic process
205 GO:0009967 positive regulation of signal transduction
205 GO:0006468 protein phosphorylation
205 GO:2000112 regulation of cellular macromolecule biosynthetic process
205 GO:0032268 regulation of cellular protein metabolic process
205 GO:0010468 regulation of gene expression
205 GO:1902531 regulation of intracellular signal transduction
205 GO:0019219 regulation of nucleobase-containing compound metabolic process
205 GO:0042325 regulation of phosphorylation
205 GO:0051049 regulation of transport
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
254 GO:0044267 cellular protein metabolic process
254 GO:0048584 positive regulation of response to stimulus
254 GO:0010468 regulation of gene expression
254 GO:0007165 signal transduction
259 GO:0007165 signal transduction
274 GO:0007165 signal transduction
282 GO:0035556 intracellular signal transduction
282 GO:0043085 positive regulation of catalytic activity
282 GO:0031325 positive regulation of cellular metabolic process
282 GO:0051173 positive regulation of nitrogen compound metabolic process
282 GO:0060255 regulation of macromolecule metabolic process
282 GO:0019220 regulation of phosphate metabolic process
284 GO:0009966 regulation of signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
355 GO:0007166 cell surface receptor signaling pathway
355 GO:0006464 cellular protein modification process
355 GO:0035556 intracellular signal transduction
355 GO:0016310 phosphorylation
355 GO:0010647 positive regulation of cell communication
355 GO:0048584 positive regulation of response to stimulus
355 GO:0023056 positive regulation of signaling
355 GO:0060255 regulation of macromolecule metabolic process
355 GO:0009966 regulation of signal transduction
367 GO:0010467 gene expression
367 GO:0007399 nervous system development
367 GO:0006139 nucleobase-containing compound metabolic process
367 GO:0019538 protein metabolic process
367 GO:0051128 regulation of cellular component organization
367 GO:0060255 regulation of macromolecule metabolic process
367 GO:0007165 signal transduction
423 GO:0006464 cellular protein modification process
423 GO:0090304 nucleic acid metabolic process
423 GO:0060255 regulation of macromolecule metabolic process
440 GO:0006464 cellular protein modification process
440 GO:0007167 enzyme linked receptor protein signaling pathway
440 GO:0035556 intracellular signal transduction
440 GO:0006928 movement of cell or subcellular component
440 GO:0016310 phosphorylation
440 GO:0031325 positive regulation of cellular metabolic process
440 GO:0010604 positive regulation of macromolecule metabolic process
440 GO:0051173 positive regulation of nitrogen compound metabolic process
440 GO:0009967 positive regulation of signal transduction
440 GO:0051128 regulation of cellular component organization
440 GO:0010468 regulation of gene expression
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
483 GO:0006464 cellular protein modification process
483 GO:0010467 gene expression
483 GO:0009059 macromolecule biosynthetic process
483 GO:0090304 nucleic acid metabolic process
483 GO:0060255 regulation of macromolecule metabolic process
483 GO:0007165 signal transduction
492 GO:0044271 cellular nitrogen compound biosynthetic process
492 GO:0051252 regulation of RNA metabolic process
492 GO:2000112 regulation of cellular macromolecule biosynthetic process
492 GO:0010468 regulation of gene expression
496 GO:0048870 cell motility
496 GO:0071310 cellular response to organic substance
496 GO:0090304 nucleic acid metabolic process
496 GO:0034654 nucleobase-containing compound biosynthetic process
496 GO:0043085 positive regulation of catalytic activity
496 GO:0031325 positive regulation of cellular metabolic process
496 GO:1902533 positive regulation of intracellular signal transduction
496 GO:0010604 positive regulation of macromolecule metabolic process
496 GO:0051173 positive regulation of nitrogen compound metabolic process
496 GO:0051128 regulation of cellular component organization
496 GO:2000112 regulation of cellular macromolecule biosynthetic process
496 GO:0010468 regulation of gene expression
496 GO:0043549 regulation of kinase activity
496 GO:0019219 regulation of nucleobase-containing compound metabolic process
496 GO:0001932 regulation of protein phosphorylation
496 GO:0009719 response to endogenous stimulus
496 GO:1901700 response to oxygen-containing compound
496 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
533 GO:0044267 cellular protein metabolic process
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
590 GO:0048468 cell development
590 GO:0007166 cell surface receptor signaling pathway
590 GO:0022607 cellular component assembly
590 GO:0032989 cellular component morphogenesis
590 GO:0006464 cellular protein modification process
590 GO:0006928 movement of cell or subcellular component
590 GO:0030182 neuron differentiation
590 GO:0120036 plasma membrane bounded cell projection organization
590 GO:0010628 positive regulation of gene expression
590 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
590 GO:0051128 regulation of cellular component organization
590 GO:0042325 regulation of phosphorylation
590 GO:0051246 regulation of protein metabolic process
590 GO:0006357 regulation of transcription from RNA polymerase II promoter
617 GO:0007165 signal transduction
682 GO:0034645 cellular macromolecule biosynthetic process
682 GO:0006464 cellular protein modification process
682 GO:0035556 intracellular signal transduction
682 GO:0090304 nucleic acid metabolic process
682 GO:0010468 regulation of gene expression
682 GO:0019219 regulation of nucleobase-containing compound metabolic process
698 GO:0090304 nucleic acid metabolic process
698 GO:0010646 regulation of cell communication
698 GO:0060255 regulation of macromolecule metabolic process
698 GO:0023051 regulation of signaling
698 GO:0007165 signal transduction
732 GO:0006355 regulation of transcription, DNA-templated
747 GO:0010467 gene expression
747 GO:0090304 nucleic acid metabolic process
750 GO:0048468 cell development
750 GO:0060255 regulation of macromolecule metabolic process
750 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
20 GO:0005886 plasma membrane
35 GO:0005829 cytosol
35 GO:0005634 nucleus
35 GO:0005886 plasma membrane
108 GO:0005829 cytosol
108 GO:0005634 nucleus
108 GO:0005886 plasma membrane
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
141 GO:0005634 nucleus
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
177 GO:0005634 nucleus
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
202 GO:0005829 cytosol
202 GO:0005886 plasma membrane
205 GO:0005829 cytosol
205 GO:0005634 nucleus
205 GO:0005886 plasma membrane
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
254 GO:0005829 cytosol
254 GO:0005634 nucleus
259 GO:0005886 plasma membrane
274 GO:0005829 cytosol
274 GO:0012505 endomembrane system
274 GO:0031982 vesicle
282 GO:0005829 cytosol
282 GO:0005886 plasma membrane
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
355 GO:0044459 plasma membrane part
367 GO:0005829 cytosol
367 GO:0070013 intracellular organelle lumen
367 GO:0005634 nucleus
423 GO:0005829 cytosol
423 GO:0005634 nucleus
440 GO:0005829 cytosol
440 GO:0005634 nucleus
440 GO:0005886 plasma membrane
440 GO:0031982 vesicle
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
483 GO:0005829 cytosol
483 GO:0031981 nuclear lumen
492 GO:0044428 nuclear part
496 GO:0005829 cytosol
496 GO:0005634 nucleus
496 GO:0005886 plasma membrane
533 GO:0005829 cytosol
563 GO:0005634 nucleus
590 GO:0005829 cytosol
590 GO:0005634 nucleus
590 GO:0005886 plasma membrane
641 GO:0005634 nucleus
682 GO:0005634 nucleus
698 GO:0043232 intracellular non-membrane-bounded organelle
698 GO:0031981 nuclear lumen
698 GO:0005886 plasma membrane
732 GO:0043232 intracellular non-membrane-bounded organelle
732 GO:0031981 nuclear lumen
747 GO:0070013 intracellular organelle lumen
747 GO:0005634 nucleus
750 GO:0005829 cytosol
750 GO:0043232 intracellular non-membrane-bounded organelle
750 GO:0005634 nucleus
750 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000278 mitotic cell cycle TAS
GO:0001843 neural tube closure IEA
GO:0001922 B-1 B cell homeostasis IEA
GO:0001934 positive regulation of protein phosphorylation IMP
GO:0002322 B cell proliferation involved in immune response IEA
GO:0002333 transitional one stage B cell differentiation IEA
GO:0006298 mismatch repair TAS
GO:0006355 regulation of transcription, DNA-templated TAS
GO:0006464 cellular protein modification process NAS
GO:0006468 protein phosphorylation IMP
GO:0006914 autophagy IEA
GO:0006974 cellular response to DNA damage stimulus IDA
GO:0006975 DNA damage induced protein phosphorylation IDA
GO:0006979 response to oxidative stress IGI
GO:0007050 cell cycle arrest TAS
GO:0007173 epidermal growth factor receptor signaling pathway IEA
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP
GO:0007229 integrin-mediated signaling pathway IMP
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage TAS
GO:0009791 post-embryonic development IEA
GO:0010506 regulation of autophagy TAS
GO:0010595 positive regulation of endothelial cell migration IMP
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:0021587 cerebellum morphogenesis IEA
GO:0022408 negative regulation of cell-cell adhesion IEA
GO:0030035 microspike assembly IEA
GO:0030036 actin cytoskeleton organization ISS
GO:0030100 regulation of endocytosis TAS
GO:0030155 regulation of cell adhesion TAS
GO:0030514 negative regulation of BMP signaling pathway IEA
GO:0030516 regulation of axon extension IMP
GO:0031113 regulation of microtubule polymerization IMP
GO:0032489 regulation of Cdc42 protein signal transduction IMP
GO:0032956 regulation of actin cytoskeleton organization IMP
GO:0033690 positive regulation of osteoblast proliferation IEA
GO:0034446 substrate adhesion-dependent cell spreading IEA
GO:0034599 cellular response to oxidative stress TAS
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway IMP
GO:0038083 peptidyl-tyrosine autophosphorylation IMP
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0038189 neuropilin signaling pathway IMP
GO:0042127 regulation of cell proliferation IBA
GO:0042770 signal transduction in response to DNA damage IDA
GO:0043065 positive regulation of apoptotic process IDA
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
GO:0043542 endothelial cell migration IMP
GO:0045087 innate immune response IBA
GO:0045184 establishment of protein localization IMP
GO:0045580 regulation of T cell differentiation ISS
GO:0045930 negative regulation of mitotic cell cycle IEA
GO:0045931 positive regulation of mitotic cell cycle IEA
GO:0046632 alpha-beta T cell differentiation IEA
GO:0046777 protein autophosphorylation IDA
GO:0048536 spleen development IEA
GO:0048538 thymus development IEA
GO:0048668 collateral sprouting IEA
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IDA
GO:0050798 activated T cell proliferation IEA
GO:0050853 B cell receptor signaling pathway IEA
GO:0050885 neuromuscular process controlling balance IEA
GO:0051149 positive regulation of muscle cell differentiation TAS
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IEA
GO:0051353 positive regulation of oxidoreductase activity IDA
GO:0051444 negative regulation of ubiquitin-protein transferase activity TAS
GO:0051496 positive regulation of stress fiber assembly IMP
GO:0051882 mitochondrial depolarization TAS
GO:0051894 positive regulation of focal adhesion assembly IMP
GO:0060020 Bergmann glial cell differentiation IEA
GO:0060563 neuroepithelial cell differentiation IEA
GO:0070301 cellular response to hydrogen peroxide IDA
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
GO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
GO:0071222 cellular response to lipopolysaccharide IEA
GO:0071901 negative regulation of protein serine/threonine kinase activity IDA
GO:0072358 cardiovascular system development IEA
GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IEA
GO:0090135 actin filament branching IEA
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading IMP
GO:1900042 positive regulation of interleukin-2 secretion IEA
GO:1900272 negative regulation of long-term synaptic potentiation ISS
GO:1900275 negative regulation of phospholipase C activity IMP
GO:1901216 positive regulation of neuron death IEA
GO:1902036 regulation of hematopoietic stem cell differentiation TAS
GO:1902715 positive regulation of interferon-gamma secretion IEA
GO:1903053 regulation of extracellular matrix organization IEA
GO:1903351 cellular response to dopamine TAS
GO:1904528 positive regulation of microtubule binding IMP
GO:1904531 positive regulation of actin filament binding IMP
GO:1905244 regulation of modification of synaptic structure ISS
GO:1905555 positive regulation blood vessel branching IEA
GO:1990051 activation of protein kinase C activity IDA
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway IEA
GO:2000145 regulation of cell motility TAS
GO:2000249 regulation of actin cytoskeleton reorganization TAS
GO:2000251 positive regulation of actin cytoskeleton reorganization IMP
GO:2000352 negative regulation of endothelial cell apoptotic process IEA
GO:2000773 negative regulation of cellular senescence IEA
GO:2001020 regulation of response to DNA damage stimulus IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005730 nucleolus IDA
GO:0005737 cytoplasm TAS
GO:0005739 mitochondrion NAS
GO:0005829 cytosol TAS
GO:0015629 actin cytoskeleton TAS
GO:0016604 nuclear body IDA
GO:0030425 dendrite ISS
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
GO:0031252 cell leading edge IEA
GO:0031965 nuclear membrane IEA
GO:0043025 neuronal cell body ISS
GO:0043234 protein complex IPI
GO:0048471 perinuclear region of cytoplasm IDA
GO:0098794 postsynapse TAS
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005654 nucleoplasm GO:0098794 postsynapse 5.72e-03 1.41e-12
Interactor Also a MoonDB EMF protein
SHD_HUMAN No
HS90B_HUMAN Yes: P08238 (MoonDB)
K1H1_HUMAN No
MED25_HUMAN No
F110A_HUMAN No
HXC8_HUMAN No
TRI39_HUMAN No
GRB2_HUMAN Yes: P62993 (MoonDB)
EGFR_HUMAN Yes: P00533 (MoonDB)
LRRK2_HUMAN No
SUV92_HUMAN No
CRKL_HUMAN No
ORC1_HUMAN No
RIN1_HUMAN No
FYN_HUMAN Yes: P06241 (MoonDB)
ERBB2_HUMAN Yes: P04626 (MoonDB)
DYN3_HUMAN No
AIRE_HUMAN No
FLNA_HUMAN Yes: P21333 (MoonDB)
P2RX7_HUMAN No
CHRD_HUMAN No
DLGP2_HUMAN No
SRPK2_HUMAN Yes: P78362 (MoonDB)
SF3B4_HUMAN No
ATM_HUMAN No
RGS20_HUMAN No
BRCA1_HUMAN No
NEK8_HUMAN No
PRIC3_HUMAN No
RIN3_HUMAN Yes: Q8TB24 (MoonDB)
SPN90_HUMAN No
3BP1_HUMAN No
ABI1_HUMAN No
ABR_HUMAN No
ACAP1_HUMAN No
AKAP6_HUMAN No
ANDR_HUMAN Yes: P10275 (MoonDB)
APOL5_HUMAN No
ARHGB_HUMAN No
ASAP1_HUMAN No
ASB16_HUMAN No
BAZ2A_HUMAN No
BMP8B_HUMAN No
BRCA2_HUMAN No
BRPF3_HUMAN No
CBL_HUMAN No
CD2AP_HUMAN No
CDC27_HUMAN No
CDKL5_HUMAN No
CDON_HUMAN No
CELR3_HUMAN No
CENPA_HUMAN No
CKAP5_HUMAN No
CNTFR_HUMAN No
CNTP1_HUMAN No
CO6_HUMAN No
CP4F2_HUMAN No
CRK_HUMAN Yes: P46108 (MoonDB)
CSMD2_HUMAN No
CTGE5_HUMAN No
CTNB1_HUMAN No
CUL7_HUMAN No
CXX1_HUMAN No
DCE1_HUMAN No
DDX41_HUMAN No
DKKL1_HUMAN No
DLGP1_HUMAN No
DLGP3_HUMAN No
DLGP4_HUMAN No
DLX4_HUMAN No
DNLI3_HUMAN No
DNSL2_HUMAN No
DOCK3_HUMAN No
DPOD1_HUMAN No
DUS15_HUMAN No
DYN1_HUMAN No
DYN2_HUMAN Yes: P50570 (MoonDB)
E41L3_HUMAN No
EFNA5_HUMAN No
EFS_HUMAN No
EPHB2_HUMAN No
EPS15_HUMAN Yes: P42566 (MoonDB)
ERBB3_HUMAN Yes: P21860 (MoonDB)
ERBB4_HUMAN No
FETUA_HUMAN No
FLNC_HUMAN No
FOXF2_HUMAN No
FYB1_HUMAN No
G3BP2_HUMAN No
GABR1_HUMAN No
GASR_HUMAN No
GNS_HUMAN No
GPR45_HUMAN No
GPX1_HUMAN No
GRIP2_HUMAN No
GSX2_HUMAN No
GT2D1_HUMAN No
HCN2_HUMAN No
HCN4_HUMAN No
HEXA_HUMAN No
HNRPR_HUMAN No
ICAL_HUMAN No
KI67_HUMAN No
KIFC2_HUMAN No
KIT_HUMAN No
KMT2B_HUMAN No
KPYM_HUMAN Yes: P14618 (MoonDB)
LAP2B_HUMAN No
LRBA_HUMAN No
LRP2_HUMAN No
LRRK1_HUMAN No
LTBP2_HUMAN No
M4K1_HUMAN No
MAAI_HUMAN No
MAVS_HUMAN No
MED14_HUMAN No
MEPE_HUMAN No
MIME_HUMAN No
MSH4_HUMAN No
MSH5_HUMAN No
MUC1_HUMAN No
NBEA_HUMAN No
NCK1_HUMAN Yes: P16333 (MoonDB)
NCKP5_HUMAN No
NCKX1_HUMAN No
NELFB_HUMAN No
NFASC_HUMAN No
NFS1_HUMAN No
NKX21_HUMAN No
NOTC3_HUMAN No
NPVF_HUMAN No
NTRK1_HUMAN No
NXPH3_HUMAN No
OSBL5_HUMAN No
P85A_HUMAN Yes: P27986 (MoonDB)
PAR3_HUMAN No
PAX3_HUMAN No
PCDA7_HUMAN No
PDE4D_HUMAN No
PDIA2_HUMAN No
PHAG1_HUMAN No
PKD1_HUMAN No
PLCG1_HUMAN Yes: P19174 (MoonDB)
PP2BA_HUMAN No
PPIP1_HUMAN No
PRAX_HUMAN No
PRDX1_HUMAN No
PTN1_HUMAN No
PTN4_HUMAN No
RIMS1_HUMAN No
RPGF1_HUMAN No
RPP38_HUMAN No
RTN4_HUMAN No
RYBP_HUMAN No
S22A3_HUMAN No
SELN_HUMAN No
SEM7A_HUMAN No
SF01_HUMAN Yes: Q15637 (MoonDB)
SHAN3_HUMAN No
SHE_HUMAN No
SNX12_HUMAN No
SNX17_HUMAN No
SNX3_HUMAN No
SNX8_HUMAN No
SOS2_HUMAN No
SP1_HUMAN No
SPR2A_HUMAN No
SPTN1_HUMAN No
SRC_HUMAN Yes: P12931 (MoonDB)
SREC2_HUMAN No
SYNJ2_HUMAN No
SYUA_HUMAN No
T2FA_HUMAN No
TF3A_HUMAN No
TGON2_HUMAN No
TM74B_HUMAN No
TSKS_HUMAN No
TULP4_HUMAN No
UBC_HUMAN Yes: P0CG48 (MoonDB)
UHMK1_HUMAN No
VAV_HUMAN No
VP13A_HUMAN No
VPREB_HUMAN No
WNK2_HUMAN No
ZDH16_HUMAN No
PMID Article Title
1281542 Secondary structure of Src homology 2 domain of c-Abl by heteronuclear NMR spectroscopy in solution.
1505033 Three-dimensional solution structure of the src homology 2 domain of c-abl.
2183353 Differential phosphorylation of c-Abl in cell cycle determined by cdc2 kinase and phosphatase activity.
2542016 N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-abl.
2687768 Nucleotide sequence analysis of human abl and bcr-abl cDNAs.
2825022 A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia.
3021337 Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
6191223 Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products.
7545908 Sequence analysis of the mutation at codon 834 and the sequence variation of codon 837 of c-abl gene.
7665185 Sequence and analysis of the human ABL gene, the BCR gene, and regions involved in the Philadelphia chromosomal translocation.
7892170 Homology modeling of the Abl-SH3 domain.
8590002 The solution structure of Abl SH3, and its relationship to SH2 in the SH(32) construct.
9037071 Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
9144171 Protein binding and signaling properties of RIN1 suggest a unique effector function.
9461559 Regulation of Rad51 function by c-Abl in response to DNA damage.
9698566 Crystal structure of the abl-SH3 domain complexed with a designed high-affinity peptide ligand: implications for SH3-ligand interactions.
10194451 A novel SH2-containing phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase (SHIP2) is constitutively tyrosine phosphorylated and associated with src homologous and collagen gene (SHC) in chronic myelogenous leukemia progenitor cells.
10325413 The DNA-binding domain of human c-Abl tyrosine kinase promotes the interaction of a HMG chromosomal protein with DNA.
10391250 Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.
11114745 Regulation of cell death by the Abl tyrosine kinase.
11374898 Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B.
11971963 c-Abl tyrosine kinase regulates the human Rad9 checkpoint protein in response to DNA damage.
12379650 Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation.
12384576 Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.
12475393 Cbl-ArgBP2 complex mediates ubiquitination and degradation of c-Abl.
12531427 c-Abl is required for oxidative stress-induced phosphorylation of caveolin-1 on tyrosine 14.
12654251 Structural basis for the autoinhibition of c-Abl tyrosine kinase.
12672821 Abl interactor 1 promotes tyrosine 296 phosphorylation of mammalian enabled (Mena) by c-Abl kinase.
12775773 Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
15031292 The c-Abl tyrosine kinase phosphorylates the Fe65 adaptor protein to stimulate Fe65/amyloid precursor protein nuclear signaling.
15164053 DNA sequence and analysis of human chromosome 9.
15302586 The c-Fes tyrosine kinase cooperates with the breakpoint cluster region protein (Bcr) to induce neurite extension in a Rac- and Cdc42-dependent manner.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15556646 Catalytic domains of tyrosine kinases determine the phosphorylation sites within c-Cbl.
15657060 c-Abl tyrosine kinase regulates caspase-9 autocleavage in the apoptotic response to DNA damage.
15686624 Role of c-Abl in the DNA damage stress response.
15696159 JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage.
15886098 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
16424036 Structure of the kinase domain of an imatinib-resistant Abl mutant in complex with the Aurora kinase inhibitor VX-680.
16543148 Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
16640460 A Src-like inactive conformation in the abl tyrosine kinase domain.
16648821 c-Abl acetylation by histone acetyltransferases regulates its nuclear-cytoplasmic localization.
16678104 Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
16912036 Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity.
16943190 Abl tyrosine kinase regulates endocytosis of the epidermal growth factor receptor.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17164530 Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.
17306540 A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
17344846 Patterns of somatic mutation in human cancer genomes.
17452790 Crystallization by capillary counter-diffusion and structure determination of the N114A mutant of the SH3 domain of Abl tyrosine kinase complexed with a high-affinity peptide ligand.
17623672 c-Abl-mediated phosphorylation of WAVE3 is required for lamellipodia formation and cell migration.
18161990 Phosphorylation of c-Abl by protein kinase Pak2 regulates differential binding of ABI2 and CRK.
18182299 Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
18328268 Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18775435 Tyrosine phosphorylation in the SH3 domain disrupts negative regulatory interactions within the c-Abl kinase core.
18945674 Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
19369195 Large-scale proteomics analysis of the human kinome.
19381274 Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19891780 Cbl-associated protein is tyrosine phosphorylated by c-Abl and c-Src kinases.
19906645 Role of interfacial water molecules in proline-rich ligand recognition by the Src homology 3 domain of Abl.
20357770 A potent and highly specific FN3 monobody inhibitor of the Abl SH2 domain.
20417104 c-Abl, Lamellipodin, and Ena/VASP proteins cooperate in dorsal ruffling of fibroblasts and axonal morphogenesis.
20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity.
20861316 Abl tyrosine kinase phosphorylates nonmuscle Myosin light chain kinase to regulate endothelial barrier function.
21269460 Initial characterization of the human central proteome.
23006999 Tyrosine phosphorylation of a SNARE protein, Syntaxin 17: Implications for membrane trafficking in the early secretory pathway.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
28288113 Germline mutations in ABL1 cause an autosomal dominant syndrome characterized by congenital heart defects and skeletal malformations.
28428613 Differential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.
OMIM ID Disease Name
608232 Leukemia, chronic myeloid
617602 Congenital heart defects and skeletal malformations syndrome
Domain Name Domain ID Source
Prot_kinase_dom IPR000719 InterPro
SH2 IPR000980 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
SH3_domain IPR001452 InterPro
Tyr_kinase_AS IPR008266 InterPro
Kinase-like_dom_sf IPR011009 InterPro
F-actin_binding IPR015015 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
ABL1 IPR033221 InterPro
ABL_SH2 IPR035837 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
Pkinase_Tyr PF07714 Pfam
F_actin_bind PF08919 Pfam
TYRKINASE PR00109 PRINTS
SH2DOMAIN PR00401 PRINTS
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_TYR PS00109 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
PTHR24418:SF88 PTHR24418:SF88 PANTHER
TVHUA S08519 PIR
TyrKc SM00219 SMART
SH2 SM00252 SMART
SH3 SM00326 SMART
FABD SM00808 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SSF56112 SSF56112 SUPFAM
SH2_ABL cd09935 CDD