Protein: P52735

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P52735 (Uniprot) VAV2_HUMAN VAV2 Guanine nucleotide exchange factor VAV2 human No
Uniprot: Guanine nucleotide exchange factor for the Rho family of Ras-related GTPases. Plays an important role in angiogenesis. Its recruitment by phosphorylated EPHA2 is critical for EFNA1-induced RAC1 GTPase activation and vascular endothelial cell migration and assembly (By similarity).
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 166, 181, 215, 376 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 467 1.88e-02 4.66e-37
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
37 GO:0007165 signal transduction
111 GO:0006955 immune response
111 GO:0035556 intracellular signal transduction
111 GO:0009967 positive regulation of signal transduction
111 GO:0006468 protein phosphorylation
111 GO:0060255 regulation of macromolecule metabolic process
111 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
166 GO:0044267 cellular protein metabolic process
166 GO:0006139 nucleobase-containing compound metabolic process
166 GO:0060255 regulation of macromolecule metabolic process
166 GO:0007165 signal transduction
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
203 GO:0016070 RNA metabolic process
203 GO:0010468 regulation of gene expression
215 GO:0044267 cellular protein metabolic process
215 GO:0007167 enzyme linked receptor protein signaling pathway
215 GO:0010467 gene expression
215 GO:0016310 phosphorylation
215 GO:1902531 regulation of intracellular signal transduction
215 GO:0060255 regulation of macromolecule metabolic process
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
376 GO:0044267 cellular protein metabolic process
376 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
451 GO:0007165 signal transduction
451 GO:0016192 vesicle-mediated transport
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
563 GO:0044267 cellular protein metabolic process
563 GO:0006139 nucleobase-containing compound metabolic process
563 GO:0010646 regulation of cell communication
563 GO:0060255 regulation of macromolecule metabolic process
563 GO:0023051 regulation of signaling
563 GO:0007165 signal transduction
683 GO:0006139 nucleobase-containing compound metabolic process
683 GO:0060255 regulation of macromolecule metabolic process
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
37 GO:0005829 cytosol
43 GO:0005634 nucleus
111 GO:0005829 cytosol
111 GO:0005886 plasma membrane
166 GO:0005829 cytosol
166 GO:0070013 intracellular organelle lumen
166 GO:0044428 nuclear part
166 GO:0005886 plasma membrane
167 GO:0005654 nucleoplasm
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
203 GO:0070013 intracellular organelle lumen
203 GO:0005634 nucleus
215 GO:0012505 endomembrane system
215 GO:0005886 plasma membrane
215 GO:0031982 vesicle
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
376 GO:0005829 cytosol
376 GO:0005634 nucleus
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
451 GO:0005829 cytosol
451 GO:0012505 endomembrane system
451 GO:0005634 nucleus
467 GO:0005654 nucleoplasm
563 GO:0005634 nucleus
683 GO:0005829 cytosol
683 GO:0070013 intracellular organelle lumen
683 GO:0005634 nucleus
703 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0001525 angiogenesis IEA
GO:0007165 signal transduction TAS
GO:0007186 G-protein coupled receptor signaling pathway TAS
GO:0007264 small GTPase mediated signal transduction IEA
GO:0008361 regulation of cell size IGI
GO:0010468 regulation of gene expression IMP
GO:0016477 cell migration IEA
GO:0030032 lamellipodium assembly IEA
GO:0030168 platelet activation TAS
GO:0030193 regulation of blood coagulation IMP
GO:0035023 regulation of Rho protein signal transduction IEA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
GO:0043065 positive regulation of apoptotic process TAS
GO:0043087 regulation of GTPase activity IGI
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity IEA
GO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
GO:0048013 ephrin receptor signaling pathway TAS
GO:0051056 regulation of small GTPase mediated signal transduction TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
7762982 Identification of VAV2 on 9q34 and its exclusion as the tuberous sclerosis gene TSC1.
12454019 Mechanism of epidermal growth factor regulation of Vav2, a guanine nucleotide exchange factor for Rac.
15164053 DNA sequence and analysis of human chromosome 9.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15561106 The proto-oncogene Fgr regulates cell migration and this requires its plasma membrane localization.
15618286 Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21269460 Initial characterization of the human central proteome.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
I51940 I51940 PIR
DH-domain IPR000219 InterPro
SH2 IPR000980 InterPro
GDS_CDC24_CS IPR001331 InterPro
SH3_domain IPR001452 InterPro
CH-domain IPR001715 InterPro
PH_domain IPR001849 InterPro
PE/DAG-bd IPR002219 InterPro
PH-like_dom_sf IPR011993 InterPro
CAMSAP_CH IPR022613 InterPro
VAV2_SH3_2 IPR035732 InterPro
VAV2_SH3_1 IPR035733 InterPro
VAV2_SH2 IPR035880 InterPro
DBL_dom_sf IPR035899 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
Calponin-like_dom_sf IPR036872 InterPro
SH2 PF00017 Pfam
C1_1 PF00130 Pfam
PH PF00169 Pfam
RhoGEF PF00621 Pfam
SH3_2 PF07653 Pfam
CAMSAP_CH PF11971 Pfam
SH2DOMAIN PR00401 PRINTS
SH3DOMAIN PR00452 PRINTS
ZF_DAG_PE_1 PS00479 PROSITE
DH_1 PS00741 PROSITE
SH2 PS50001 PROSITE
SH3 PS50002 PROSITE
PH_DOMAIN PS50003 PROSITE
DH_2 PS50010 PROSITE
CH PS50021 PROSITE
ZF_DAG_PE_2 PS50081 PROSITE
CH SM00033 SMART
C1 SM00109 SMART
PH SM00233 SMART
SH2 SM00252 SMART
RhoGEF SM00325 SMART
SH3 SM00326 SMART
SSF47576 SSF47576 SUPFAM
SSF48065 SSF48065 SUPFAM
SSF50044 SSF50044 SUPFAM
SSF50729 SSF50729 SUPFAM
SSF55550 SSF55550 SUPFAM
CH cd00014 CDD
C1 cd00029 CDD
RhoGEF cd00160 CDD
SH2_Vav2 cd10406 CDD
SH3_VAV2_2 cd11977 CDD
SH3_VAV2_1 cd11980 CDD