Protein: P42684

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P42684 (Uniprot) ABL2_HUMAN ABL2 Abelson tyrosine-protein kinase 2 human No
Uniprot: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 187 GO:0034641 cellular nitrogen compound metabolic process 327 4.22e-144 6.90e-18
Module ID (MoonGO) GO ID (BP) GO Name
186 GO:0048468 cell development
186 GO:0007166 cell surface receptor signaling pathway
186 GO:0044267 cellular protein metabolic process
186 GO:0035556 intracellular signal transduction
186 GO:0030182 neuron differentiation
186 GO:0006796 phosphate-containing compound metabolic process
186 GO:0120036 plasma membrane bounded cell projection organization
186 GO:0060255 regulation of macromolecule metabolic process
186 GO:0009966 regulation of signal transduction
187 GO:0007166 cell surface receptor signaling pathway
187 GO:0006464 cellular protein modification process
187 GO:0070887 cellular response to chemical stimulus
187 GO:0035556 intracellular signal transduction
187 GO:0006928 movement of cell or subcellular component
187 GO:0006796 phosphate-containing compound metabolic process
187 GO:0010647 positive regulation of cell communication
187 GO:0048584 positive regulation of response to stimulus
187 GO:0023056 positive regulation of signaling
187 GO:0060255 regulation of macromolecule metabolic process
187 GO:0009966 regulation of signal transduction
259 GO:0007165 signal transduction
327 GO:0044271 cellular nitrogen compound biosynthetic process
327 GO:0044267 cellular protein metabolic process
327 GO:0006139 nucleobase-containing compound metabolic process
327 GO:0031325 positive regulation of cellular metabolic process
327 GO:0031326 regulation of cellular biosynthetic process
327 GO:0010468 regulation of gene expression
327 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
186 GO:0005829 cytosol
186 GO:0005886 plasma membrane
186 GO:0031982 vesicle
187 GO:0005829 cytosol
187 GO:0005886 plasma membrane
259 GO:0005886 plasma membrane
327 GO:0005829 cytosol
327 GO:0043232 intracellular non-membrane-bounded organelle
327 GO:0005634 nucleus
327 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006464 cellular protein modification process TAS
GO:0007155 cell adhesion IEA
GO:0007165 signal transduction TAS
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA
GO:0007204 positive regulation of cytosolic calcium ion concentration IMP
GO:0010506 regulation of autophagy TAS
GO:0010863 positive regulation of phospholipase C activity IMP
GO:0010976 positive regulation of neuron projection development IMP
GO:0018108 peptidyl-tyrosine phosphorylation IDA
GO:0030100 regulation of endocytosis TAS
GO:0030155 regulation of cell adhesion TAS
GO:0038083 peptidyl-tyrosine autophosphorylation IBA
GO:0042127 regulation of cell proliferation IBA
GO:0045087 innate immune response IBA
GO:0051353 positive regulation of oxidoreductase activity IDA
GO:0071300 cellular response to retinoic acid IMP
GO:2000145 regulation of cell motility TAS
GO:2000249 regulation of actin cytoskeleton reorganization TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0015629 actin cytoskeleton TAS
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane IBA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
2198571 The complete coding sequence of arg defines the Abelson subfamily of cytoplasmic tyrosine kinases.
3787260 A novel human gene closely related to the abl proto-oncogene.
12748290 Two distinct phosphorylation pathways have additive effects on Abl family kinase activation.
12775773 Regulation of F-actin-dependent processes by the Abl family of tyrosine kinases.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14729179 How do Abl family kinases regulate cell shape and movement?
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15735735 Ubiquitination and degradation of the Arg tyrosine kinase is regulated by oxidative stress.
15886098 RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration.
16678104 Interaction between c-Abl and Arg tyrosine kinases and proteasome subunit PSMA7 regulates proteasome degradation.
16710414 The DNA sequence and biological annotation of human chromosome 1.
16964243 A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
17306540 A critical role for cortactin phosphorylation by Abl-family kinases in PDGF-induced dorsal-wave formation.
17344846 Patterns of somatic mutation in human cancer genomes.
17525332 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
17974005 The full-ORF clone resource of the German cDNA consortium.
18182299 Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.
18669648 A quantitative atlas of mitotic phosphorylation.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18810762 Eight full-length abelson related gene (Arg) isoforms are constitutively expressed in caki-1 cell line and cell distribution of two isoforms has been analyzed after transfection.
18945674 Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components.
19369195 Large-scale proteomics analysis of the human kinome.
19381274 Unc119 protects from Shigella infection by inhibiting the Abl family kinases.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20841568 ABL tyrosine kinases: evolution of function, regulation, and specificity.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
21417343 Crystal structures of ABL-related gene (ABL2) in complex with imatinib, tozasertib (VX-680), and a type I inhibitor of the triazole carbothioamide class.
22297987 Lysozyme contamination facilitates crystallization of a heterotrimeric cortactin-Arg-lysozyme complex.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
No results found.
Domain Name Domain ID Source
A35962 A35962 PIR
B35962 B35962 PIR
Prot_kinase_dom IPR000719 InterPro
SH2 IPR000980 InterPro
Ser-Thr/Tyr_kinase_cat_dom IPR001245 InterPro
SH3_domain IPR001452 InterPro
Tyr_kinase_AS IPR008266 InterPro
Kinase-like_dom_sf IPR011009 InterPro
F-actin_binding IPR015015 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Tyr_kinase_cat_dom IPR020635 InterPro
ABL_SH2 IPR035837 InterPro
SH3-like_dom_sf IPR036028 InterPro
SH2_dom_sf IPR036860 InterPro
SH2 PF00017 Pfam
SH3_1 PF00018 Pfam
Pkinase_Tyr PF07714 Pfam
F_actin_bind PF08919 Pfam
TyrKc SM00219 SMART
SSF50044 SSF50044 SUPFAM
SSF55550 SSF55550 SUPFAM
SSF56112 SSF56112 SUPFAM
SH2_ABL cd09935 CDD