Protein: P68400

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P68400 (Uniprot) CSK21_HUMAN CSNK2A1 Casein kinase II subunit alpha human No
Uniprot: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV. Phosphorylates PML at 'Ser-565' and primes it for ubiquitin-mediated degradation. Plays an important role in the circadian clock function by phosphorylating ARNTL/BMAL1 at 'Ser-90' which is pivotal for its interaction with CLOCK and which controls CLOCK nuclear entry (PubMed:11239457, PubMed:11704824, PubMed:16193064, PubMed:19188443, PubMed:20625391, PubMed:22406621). Phosphorylates CCAR2 at 'Thr-454' in gastric carcinoma tissue (PubMed:24962073). more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0019538 protein metabolic process 15, 706 GO:0016070 RNA metabolic process 75, 689 5.15e-08 2.82e-13
GO:0019538 protein metabolic process 15, 706 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 353, 467 1.88e-02 4.66e-37
GO:0036211 protein modification process 28, 674 GO:0016070 RNA metabolic process 75, 689 5.81e-04 8.44e-05
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
15 GO:0044267 cellular protein metabolic process
28 GO:0006464 cellular protein modification process
28 GO:0031324 negative regulation of cellular metabolic process
28 GO:0010605 negative regulation of macromolecule metabolic process
28 GO:0051172 negative regulation of nitrogen compound metabolic process
28 GO:0031325 positive regulation of cellular metabolic process
28 GO:0010604 positive regulation of macromolecule metabolic process
28 GO:0051173 positive regulation of nitrogen compound metabolic process
28 GO:0048584 positive regulation of response to stimulus
28 GO:0009966 regulation of signal transduction
28 GO:0006355 regulation of transcription, DNA-templated
47 GO:0044271 cellular nitrogen compound biosynthetic process
47 GO:0051252 regulation of RNA metabolic process
47 GO:0010468 regulation of gene expression
75 GO:0016071 mRNA metabolic process
75 GO:0051252 regulation of RNA metabolic process
75 GO:0010468 regulation of gene expression
75 GO:0006351 transcription, DNA-templated
81 GO:0006139 nucleobase-containing compound metabolic process
99 GO:0031325 positive regulation of cellular metabolic process
99 GO:0010628 positive regulation of gene expression
99 GO:0051173 positive regulation of nitrogen compound metabolic process
99 GO:0019538 protein metabolic process
99 GO:0006357 regulation of transcription from RNA polymerase II promoter
99 GO:0007165 signal transduction
107 GO:0016070 RNA metabolic process
107 GO:0044267 cellular protein metabolic process
107 GO:0034654 nucleobase-containing compound biosynthetic process
107 GO:2000112 regulation of cellular macromolecule biosynthetic process
107 GO:0010468 regulation of gene expression
107 GO:0019219 regulation of nucleobase-containing compound metabolic process
107 GO:0007165 signal transduction
167 GO:0016070 RNA metabolic process
167 GO:0010467 gene expression
167 GO:0060255 regulation of macromolecule metabolic process
209 GO:0031324 negative regulation of cellular metabolic process
209 GO:0010605 negative regulation of macromolecule metabolic process
209 GO:0051172 negative regulation of nitrogen compound metabolic process
209 GO:0009893 positive regulation of metabolic process
209 GO:0006357 regulation of transcription from RNA polymerase II promoter
209 GO:0007165 signal transduction
218 GO:0060255 regulation of macromolecule metabolic process
261 GO:0006355 regulation of transcription, DNA-templated
323 GO:0016070 RNA metabolic process
323 GO:0034654 nucleobase-containing compound biosynthetic process
323 GO:0009893 positive regulation of metabolic process
323 GO:0006468 protein phosphorylation
323 GO:2000112 regulation of cellular macromolecule biosynthetic process
323 GO:0010468 regulation of gene expression
323 GO:0019219 regulation of nucleobase-containing compound metabolic process
323 GO:0007165 signal transduction
353 GO:0000398 mRNA splicing, via spliceosome
463 GO:0090304 nucleic acid metabolic process
463 GO:0060255 regulation of macromolecule metabolic process
467 GO:0000398 mRNA splicing, via spliceosome
467 GO:0060255 regulation of macromolecule metabolic process
493 GO:0016070 RNA metabolic process
493 GO:0010467 gene expression
535 GO:0008219 cell death
535 GO:0044267 cellular protein metabolic process
535 GO:0071495 cellular response to endogenous stimulus
535 GO:0071310 cellular response to organic substance
535 GO:0010605 negative regulation of macromolecule metabolic process
535 GO:0045893 positive regulation of transcription, DNA-templated
535 GO:0006357 regulation of transcription from RNA polymerase II promoter
535 GO:0007165 signal transduction
546 GO:0051252 regulation of RNA metabolic process
546 GO:2000112 regulation of cellular macromolecule biosynthetic process
546 GO:0010468 regulation of gene expression
580 GO:0044271 cellular nitrogen compound biosynthetic process
580 GO:0090304 nucleic acid metabolic process
580 GO:0060255 regulation of macromolecule metabolic process
616 GO:0090304 nucleic acid metabolic process
656 GO:0016070 RNA metabolic process
656 GO:0034645 cellular macromolecule biosynthetic process
656 GO:0044271 cellular nitrogen compound biosynthetic process
656 GO:0010467 gene expression
656 GO:0060255 regulation of macromolecule metabolic process
661 GO:0016070 RNA metabolic process
661 GO:0010467 gene expression
662 GO:0034645 cellular macromolecule biosynthetic process
662 GO:0044271 cellular nitrogen compound biosynthetic process
662 GO:0090304 nucleic acid metabolic process
674 GO:0006464 cellular protein modification process
674 GO:0031324 negative regulation of cellular metabolic process
674 GO:0010605 negative regulation of macromolecule metabolic process
674 GO:0051172 negative regulation of nitrogen compound metabolic process
674 GO:0010604 positive regulation of macromolecule metabolic process
674 GO:2000112 regulation of cellular macromolecule biosynthetic process
674 GO:0010468 regulation of gene expression
674 GO:1903506 regulation of nucleic acid-templated transcription
674 GO:0007165 signal transduction
674 GO:0006351 transcription, DNA-templated
689 GO:0006396 RNA processing
689 GO:0051252 regulation of RNA metabolic process
689 GO:0010468 regulation of gene expression
706 GO:0044267 cellular protein metabolic process
706 GO:0090304 nucleic acid metabolic process
706 GO:0034654 nucleobase-containing compound biosynthetic process
706 GO:2000112 regulation of cellular macromolecule biosynthetic process
706 GO:0010468 regulation of gene expression
706 GO:0019219 regulation of nucleobase-containing compound metabolic process
706 GO:0007165 signal transduction
714 GO:0016070 RNA metabolic process
714 GO:0010468 regulation of gene expression
758 GO:0016070 RNA metabolic process
758 GO:0034645 cellular macromolecule biosynthetic process
758 GO:0044271 cellular nitrogen compound biosynthetic process
758 GO:0044267 cellular protein metabolic process
758 GO:0009893 positive regulation of metabolic process
758 GO:0010468 regulation of gene expression
758 GO:0019219 regulation of nucleobase-containing compound metabolic process
759 GO:0016070 RNA metabolic process
795 GO:0006464 cellular protein modification process
821 GO:0006259 DNA metabolic process
821 GO:0007166 cell surface receptor signaling pathway
821 GO:0034613 cellular protein localization
821 GO:0071495 cellular response to endogenous stimulus
821 GO:0071310 cellular response to organic substance
821 GO:0031324 negative regulation of cellular metabolic process
821 GO:0010605 negative regulation of macromolecule metabolic process
821 GO:0051172 negative regulation of nitrogen compound metabolic process
821 GO:0031328 positive regulation of cellular biosynthetic process
821 GO:0010557 positive regulation of macromolecule biosynthetic process
821 GO:0045935 positive regulation of nucleobase-containing compound metabolic process
821 GO:0048584 positive regulation of response to stimulus
821 GO:0006468 protein phosphorylation
821 GO:0031399 regulation of protein modification process
821 GO:0006355 regulation of transcription, DNA-templated
821 GO:1901700 response to oxygen-containing compound
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
28 GO:0005829 cytosol
28 GO:0043232 intracellular non-membrane-bounded organelle
28 GO:0005654 nucleoplasm
47 GO:0005654 nucleoplasm
75 GO:0005829 cytosol
75 GO:0005654 nucleoplasm
81 GO:0005829 cytosol
81 GO:0031981 nuclear lumen
99 GO:0005654 nucleoplasm
107 GO:0005829 cytosol
107 GO:0005654 nucleoplasm
167 GO:0005654 nucleoplasm
209 GO:0005654 nucleoplasm
218 GO:0005634 nucleus
261 GO:0031981 nuclear lumen
323 GO:0005829 cytosol
323 GO:0043232 intracellular non-membrane-bounded organelle
323 GO:0070013 intracellular organelle lumen
323 GO:0044428 nuclear part
328 GO:0005829 cytosol
328 GO:0043232 intracellular non-membrane-bounded organelle
328 GO:0005654 nucleoplasm
353 GO:0005654 nucleoplasm
463 GO:0005654 nucleoplasm
467 GO:0005654 nucleoplasm
493 GO:0031981 nuclear lumen
535 GO:0005829 cytosol
535 GO:0043232 intracellular non-membrane-bounded organelle
535 GO:0005654 nucleoplasm
546 GO:0070013 intracellular organelle lumen
546 GO:0044428 nuclear part
580 GO:0005829 cytosol
580 GO:0070013 intracellular organelle lumen
580 GO:0005634 nucleus
616 GO:0005654 nucleoplasm
656 GO:0043232 intracellular non-membrane-bounded organelle
656 GO:0005634 nucleus
661 GO:0005654 nucleoplasm
662 GO:0043232 intracellular non-membrane-bounded organelle
662 GO:0005634 nucleus
674 GO:0005829 cytosol
674 GO:0043232 intracellular non-membrane-bounded organelle
674 GO:0005654 nucleoplasm
689 GO:0005654 nucleoplasm
706 GO:0005829 cytosol
706 GO:0031981 nuclear lumen
714 GO:0031981 nuclear lumen
758 GO:0005654 nucleoplasm
759 GO:0031981 nuclear lumen
795 GO:0070013 intracellular organelle lumen
821 GO:0005829 cytosol
821 GO:0005654 nucleoplasm
821 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006351 transcription, DNA-templated IEA
GO:0006355 regulation of transcription, DNA-templated IEA
GO:0006457 protein folding TAS
GO:0006468 protein phosphorylation IDA
GO:0006656 phosphatidylcholine biosynthetic process TAS
GO:0006915 apoptotic process IEA
GO:0007049 cell cycle IEA
GO:0007165 signal transduction TAS
GO:0008284 positive regulation of cell proliferation IDA
GO:0016055 Wnt signaling pathway IEA
GO:0016236 macroautophagy TAS
GO:0018107 peptidyl-threonine phosphorylation IDA
GO:0021987 cerebral cortex development IEA
GO:0030177 positive regulation of Wnt signaling pathway IMP
GO:0030307 positive regulation of cell growth IDA
GO:0033574 response to testosterone IEA
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
GO:0045732 positive regulation of protein catabolic process IDA
GO:0046777 protein autophosphorylation IEA
GO:0048511 rhythmic process IEA
GO:0061077 chaperone-mediated protein folding TAS
GO:0097421 liver regeneration IEA
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO:1903076 regulation of protein localization to plasma membrane IEA
GO:1905818 regulation of chromosome separation IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus IDA
GO:0005654 nucleoplasm TAS
GO:0005829 cytosol TAS
GO:0005886 plasma membrane IEA
GO:0005956 protein kinase CK2 complex IDA
GO:0016580 Sin3 complex IDA
GO:0016581 NuRD complex IDA
GO:0031519 PcG protein complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005886 plasma membrane 5.35e-300 7.52e-165
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
Interactor Also a MoonDB EMF protein
PO6F2_HUMAN No
PSA3_HUMAN Yes: P25788 (MoonDB)
THAP1_HUMAN No
MEOX2_HUMAN Yes: P50222 (MoonDB)
BEND7_HUMAN No
PROP1_HUMAN No
REL_HUMAN No
KIF24_HUMAN No
STAC3_HUMAN No
A0A0C3SFZ9_HUMAN No
A0A0C4DFT8_HUMAN No
ACINU_HUMAN No
AIP_HUMAN No
AKAP8_HUMAN No
ALKB5_HUMAN No
AN32B_HUMAN No
APC_HUMAN No
AR6P4_HUMAN No
ARMX3_HUMAN No
AT2B1_HUMAN No
ATF1_HUMAN No
ATF2_HUMAN No
ATPA_HUMAN No
B4DY08_HUMAN No
BCLF1_HUMAN No
BHE40_HUMAN Yes: O14503 (MoonDB)
BHE41_HUMAN No
BIRC6_HUMAN No
BMS1_HUMAN No
CALU_HUMAN No
CALX_HUMAN No
CBP_HUMAN No
CCDC6_HUMAN No
CD11A_HUMAN No
CD2B2_HUMAN No
CHD4_HUMAN No
CIRBP_HUMAN No
CLAP2_HUMAN No
CND1_HUMAN No
CPSF6_HUMAN No
CPSF7_HUMAN No
CSK22_HUMAN No
CSK2B_HUMAN Yes: P67870 (MoonDB)
CSN3_HUMAN No
CSN7A_HUMAN No
CT451_HUMAN No
DDX17_HUMAN No
DDX21_HUMAN No
DDX24_HUMAN No
DDX3X_HUMAN No
DDX54_HUMAN No
DEC1_HUMAN No
DEK_HUMAN No
DHX16_HUMAN No
DKC1_HUMAN No
DVL1_HUMAN No
EF1B_HUMAN No
EF1D_HUMAN No
EIF3J_HUMAN No
EXOS9_HUMAN No
FHOD3_HUMAN No
FIP1_HUMAN No
FNBP4_HUMAN No
FOS_HUMAN No
FXR1_HUMAN No
GPN1_HUMAN No
GPT2L_HUMAN No
GRB14_HUMAN No
HAP28_HUMAN No
HDAC1_HUMAN No
HDAC2_HUMAN No
HDGR2_HUMAN No
HIF1A_HUMAN No
HIRP3_HUMAN No
HMGA1_HUMAN No
HNRDL_HUMAN No
HNRPC_HUMAN No
HNRPL_HUMAN No
HS90A_HUMAN Yes: P07900 (MoonDB)
HS90B_HUMAN Yes: P08238 (MoonDB)
HTSF1_HUMAN No
HXC4_HUMAN No
ICLN_HUMAN No
IF2A_HUMAN No
IF2B_HUMAN No
IF2P_HUMAN No
IF4B_HUMAN No
IMA3_HUMAN No
INF2_HUMAN No
IWS1_HUMAN No
JUN_HUMAN No
KANK2_HUMAN No
KAPCB_HUMAN No
KEAP1_HUMAN No
KIF5C_HUMAN No
KRI1_HUMAN No
LAP2B_HUMAN No
LARP1_HUMAN No
LARP7_HUMAN No
LA_HUMAN No
LEO1_HUMAN No
LHX3_HUMAN No
LHX8_HUMAN No
LHX9_HUMAN No
LRC59_HUMAN No
LS14A_HUMAN No
LTV1_HUMAN No
LYRIC_HUMAN No
MAGAB_HUMAN Yes: P43364 (MoonDB)
MAK16_HUMAN No
MCM2_HUMAN No
MCM3_HUMAN No
MDC1_HUMAN No
MEOX1_HUMAN No
MFAP1_HUMAN No
MPP10_HUMAN No
MSH6_HUMAN No
NADAP_HUMAN No
NAF1_HUMAN No
NFYA_HUMAN No
NMD3_HUMAN No
NMT1_HUMAN No
NOP56_HUMAN No
NOP58_HUMAN No
NPM_HUMAN No
NUCL_HUMAN No
NUP98_HUMAN No
NXF1_HUMAN No
OSBP1_HUMAN No
P53_HUMAN Yes: P04637 (MoonDB)
PAIRB_HUMAN No
PAX5_HUMAN No
PAX6_HUMAN No
PDCD4_HUMAN No
PDIA6_HUMAN No
PININ_HUMAN No
PKHO1_HUMAN No
PML_HUMAN No
PR38A_HUMAN No
PR40A_HUMAN Yes: O75400 (MoonDB)
PRCC_HUMAN No
PRP16_HUMAN No
PSIP1_HUMAN No
PTN1_HUMAN No
PURB_HUMAN No
Q86V38_HUMAN No
RBM10_HUMAN Yes: P98175 (MoonDB)
RBM33_HUMAN No
RBMX_HUMAN No
RIOK2_HUMAN No
RL13_HUMAN No
RL1D1_HUMAN No
RL5_HUMAN No
RL6_HUMAN No
RLA0_HUMAN No
RLA1_HUMAN No
RM04_HUMAN No
RM38_HUMAN No
RN111_HUMAN Yes: Q6ZNA4 (MoonDB)
ROA2_HUMAN No
RPRD2_HUMAN No
RRP12_HUMAN No
RRP1B_HUMAN No
RS18_HUMAN No
RS3_HUMAN No
RSF1_HUMAN No
RU17_HUMAN Yes: P08621 (MoonDB)
S30BP_HUMAN No
S39A7_HUMAN No
SAFB1_HUMAN No
SDS3_HUMAN No
SEPT2_HUMAN No
SET_HUMAN No
SF3A1_HUMAN No
SF3B1_HUMAN No
SF3B2_HUMAN No
SFPQ_HUMAN No
SLIRP_HUMAN No
SMRC2_HUMAN No
SND1_HUMAN No
SPB1_HUMAN No
SPF45_HUMAN No
SPS2L_HUMAN No
SPT5H_HUMAN No
SPT6H_HUMAN No
SPTB2_HUMAN No
SRRM1_HUMAN No
SRRM2_HUMAN No
SRRT_HUMAN No
SRS10_HUMAN No
SRS11_HUMAN No
SRSF2_HUMAN No
SSF1_HUMAN No
SSRP1_HUMAN No
SURF6_HUMAN No
SYUA_HUMAN No
TB182_HUMAN No
TCP4_HUMAN No
TF65_HUMAN No
THOC5_HUMAN No
TMOD3_HUMAN No
TOP2A_HUMAN No
TR150_HUMAN No
TRI41_HUMAN Yes: Q8WV44 (MoonDB)
U3IP2_HUMAN No
UBP24_HUMAN No
UT14A_HUMAN No
UTP18_HUMAN No
VIGLN_HUMAN No
WASP_HUMAN No
WDR44_HUMAN No
WDR55_HUMAN No
XRN2_HUMAN No
YBOX1_HUMAN No
ZC3H1_HUMAN No
ZC3H8_HUMAN No
ZC3HD_HUMAN No
ZC3HF_HUMAN No
ZHX1_HUMAN No
ZN440_HUMAN No
ZN670_HUMAN No
ZRAB2_HUMAN No
PMID Article Title
2174700 Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II.
2752008 Molecular cloning of the human casein kinase II alpha subunit.
7592773 Phosphorylation of casein kinase II by p34cdc2. Identification of phosphorylation sites using phosphorylation site mutants in vitro.
8420794 Structure and sequence of an intronless gene for human casein kinase II-alpha subunit.
11092945 Crystallization and preliminary characterization of crystals of human protein kinase CK2.
11239457 A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1.
11574463 Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
11704824 Protein kinase CK2 is involved in G2 arrest and apoptosis following spindle damage in epithelial cells.
11780052 The DNA sequence and comparative analysis of human chromosome 20.
12393879 p53 serine 392 phosphorylation increases after UV through induction of the assembly of the CK2.hSPT16.SSRP1 complex.
12631575 One-thousand-and-one substrates of protein kinase CK2?
12860116 Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit.
14646071 Three-dimensional atomic structure of a catalytic subunit mutant of human protein kinase CK2.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15684395 Activation of pre-mRNA splicing by human RNPS1 is regulated by CK2 phosphorylation.
16193064 Caspase-2 primes cancer cells for TRAIL-mediated apoptosis by processing procaspase-8.
18691976 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
19054851 Human protein factory for converting the transcriptome into an in vitro-expressed proteome.
19188443 Evidence for regulation of mitotic progression through temporal phosphorylation and dephosphorylation of CK2alpha.
19387549 Protein kinase CK2 in health and disease: CK2 and its role in Wnt and NF-kappaB signaling: linking development and cancer.
19387550 Protein kinase CK2 in health and disease: CK2: the kinase controlling the Hsp90 chaperone machinery.
19387551 Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.
19387552 Protein kinase CK2 in health and disease: From birth to death: the role of protein kinase CK2 in the regulation of cell proliferation and survival.
19387553 Protein kinase CK2 in health and disease: Protein kinase CK2: from structures to insights.
19923321 Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
20625391 Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer.
21269460 Initial characterization of the human central proteome.
22406621 The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
24962073 CK2alpha phosphorylates DBC1 and is involved in the progression of gastric carcinoma and predicts poor survival of gastric carcinoma patients.
27048600 De novo mutations in CSNK2A1 are associated with neurodevelopmental abnormalities and dysmorphic features.
OMIM ID Disease Name
617062 Okur-Chung neurodevelopmental syndrome
Domain Name Domain ID Source
A30319 A30319 PIR
Prot_kinase_dom IPR000719 InterPro
Ser/Thr_kinase_AS IPR008271 InterPro
Kinase-like_dom_sf IPR011009 InterPro
Protein_kinase_ATP_BS IPR017441 InterPro
Pkinase PF00069 Pfam
PROTEIN_KINASE_ATP PS00107 PROSITE
PROTEIN_KINASE_ST PS00108 PROSITE
PROTEIN_KINASE_DOM PS50011 PROSITE
S_TKc SM00220 SMART
SSF56112 SSF56112 SUPFAM