Protein: O15151

Uniprot: Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0009056 catabolic process 125 GO:0009059 macromolecule biosynthetic process 391 6.37e-04 1.88e-40
Module ID (MoonGO) GO ID (BP) GO Name
125 GO:0044248 cellular catabolic process
125 GO:0016567 protein ubiquitination
125 GO:0060255 regulation of macromolecule metabolic process
159 GO:0006464 cellular protein modification process
159 GO:0006355 regulation of transcription, DNA-templated
159 GO:0007165 signal transduction
391 GO:0034645 cellular macromolecule biosynthetic process
391 GO:0090304 nucleic acid metabolic process
391 GO:0034654 nucleobase-containing compound biosynthetic process
391 GO:0060255 regulation of macromolecule metabolic process
391 GO:0019219 regulation of nucleobase-containing compound metabolic process
Module ID (MoonGO) GO ID (CC) GO Name
125 GO:0005829 cytosol
125 GO:0005634 nucleus
159 GO:0005829 cytosol
159 GO:0005654 nucleoplasm
391 GO:0070013 intracellular organelle lumen
391 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA
GO:0006461 protein complex assembly IDA
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS
GO:0008283 cell proliferation IEP
GO:0008285 negative regulation of cell proliferation TAS
GO:0016567 protein ubiquitination IEA
GO:0016579 protein deubiquitination TAS
GO:0030330 DNA damage response, signal transduction by p53 class mediator IEP
GO:0042177 negative regulation of protein catabolic process IMP
GO:0043066 negative regulation of apoptotic process IEA
GO:0045023 G0 to G1 transition IEP
GO:0050821 protein stabilization IEP
GO:0071157 negative regulation of cell cycle arrest IEA
GO:0071456 cellular response to hypoxia IEP
GO:1901796 regulation of signal transduction by p53 class mediator TAS
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005634 nucleus NAS
GO:0005654 nucleoplasm TAS
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9226370 Isolation and identification of the human homolog of a new p53-binding protein, Mdmx.
10608892 Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein.
11840567 Cluster analysis of an extensive human breast cancer cell line protein expression map database.
12761890 Identification of a domain within MDMX-S that is responsible for its high affinity interaction with p53 and high-level expression in mammalian cells.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16163388 ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
16266988 Identification of an aberrantly spliced form of HDMX in human tumors: a new mechanism for HDM2 stabilization.
16511572 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
16710414 The DNA sequence and biological annotation of human chromosome 1.
19838211 MdmX is a substrate for the deubiquitinating enzyme USP2a.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
No results found.
Domain Name Domain ID Source
Znf_RING IPR001841 InterPro
Znf_RanBP2 IPR001876 InterPro
SWIB_MDM2_domain IPR003121 InterPro
Znf_RING/FYVE/PHD IPR013083 InterPro
MDM4 IPR015458 InterPro
p53_neg-reg_MDM_2/4 IPR016495 InterPro
Znf_RanBP2_sf IPR036443 InterPro
SWIB_MDM2_dom_sf IPR036885 InterPro
zf-RanBP PF00641 Pfam
SWIB PF02201 Pfam
p53_MDM_2/4 PIRSF006748 PIRSF
SSF47592 SSF47592 SUPFAM
SSF90209 SSF90209 SUPFAM