Protein: Q86VP1

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q86VP1 (Uniprot) TAXB1_HUMAN TAX1BP1 Tax1-binding protein 1 human No
Uniprot: Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0006139 nucleobase-containing compound metabolic process 132, 444 GO:0033036 macromolecule localization 517 4.58e-19 9.70e-72
Module ID (MoonGO) GO ID (BP) GO Name
67 GO:0060255 regulation of macromolecule metabolic process
132 GO:0090304 nucleic acid metabolic process
132 GO:0060255 regulation of macromolecule metabolic process
134 GO:0044267 cellular protein metabolic process
134 GO:0060255 regulation of macromolecule metabolic process
134 GO:0007165 signal transduction
181 GO:0044267 cellular protein metabolic process
181 GO:0010467 gene expression
181 GO:0009059 macromolecule biosynthetic process
181 GO:0090304 nucleic acid metabolic process
181 GO:0060255 regulation of macromolecule metabolic process
181 GO:0007165 signal transduction
444 GO:0090304 nucleic acid metabolic process
444 GO:0060255 regulation of macromolecule metabolic process
444 GO:0019219 regulation of nucleobase-containing compound metabolic process
444 GO:0007165 signal transduction
517 GO:0008104 protein localization
517 GO:0019538 protein metabolic process
549 GO:0008219 cell death
549 GO:0070887 cellular response to chemical stimulus
549 GO:0033554 cellular response to stress
549 GO:0035556 intracellular signal transduction
549 GO:0031325 positive regulation of cellular metabolic process
549 GO:0010604 positive regulation of macromolecule metabolic process
549 GO:0051173 positive regulation of nitrogen compound metabolic process
549 GO:0048584 positive regulation of response to stimulus
549 GO:0006468 protein phosphorylation
549 GO:0051252 regulation of RNA metabolic process
549 GO:2000112 regulation of cellular macromolecule biosynthetic process
549 GO:0032268 regulation of cellular protein metabolic process
549 GO:0010468 regulation of gene expression
549 GO:0009966 regulation of signal transduction
549 GO:0006351 transcription, DNA-templated
713 GO:0090304 nucleic acid metabolic process
713 GO:0070647 protein modification by small protein conjugation or removal
713 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
67 GO:0005634 nucleus
132 GO:0005634 nucleus
134 GO:0005829 cytosol
134 GO:0005634 nucleus
181 GO:0005829 cytosol
181 GO:0005654 nucleoplasm
264 GO:0012505 endomembrane system
444 GO:0005634 nucleus
517 GO:0005829 cytosol
517 GO:0012505 endomembrane system
517 GO:0031982 vesicle
549 GO:0005829 cytosol
549 GO:0005634 nucleus
713 GO:0005829 cytosol
713 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006915 apoptotic process IEA
GO:0010803 regulation of tumor necrosis factor-mediated signaling pathway TAS
GO:0032088 negative regulation of NF-kappaB transcription factor activity ISS
GO:0032480 negative regulation of type I interferon production TAS
GO:0043066 negative regulation of apoptotic process IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005829 cytosol TAS
GO:0070062 extracellular exosome IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
10435631 The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases.
10920205 T6BP, a TRAF6-interacting protein involved in IL-1 signaling.
11230166 Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
12690205 Human chromosome 7: DNA sequence and biology.
12853948 The DNA sequence of human chromosome 7.
14530271 Protein profile of tax-associated complexes.
14697242 Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins.
14702039 Complete sequencing and characterization of 21,243 full-length human cDNAs.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
16959974 The consensus coding sequences of human breast and colorectal cancers.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
21765415 The kinase IKKalpha inhibits activation of the transcription factor NF-kappaB by phosphorylating the regulatory molecule TAX1BP1.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24239949 The structure of TAX1BP1 UBZ1+2 provides insight into target specificity and adaptability.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
27062441 A novel mode of ubiquitin recognition by the ubiquitin-binding zinc finger domain of WRNIP1.
No results found.
Domain Name Domain ID Source
G02043 G02043 PIR
CALCOCO1-like IPR012852 InterPro
CALCOCO1 PF07888 Pfam