Protein: O00499

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
O00499 (Uniprot) BIN1_HUMAN BIN1 Myc box-dependent-interacting protein 1 human No
Uniprot: May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0010646 regulation of cell communication 284 GO:0006139 nucleobase-containing compound metabolic process 497 6.71e-28 7.52e-07
Module ID (MoonGO) GO ID (BP) GO Name
284 GO:0009966 regulation of signal transduction
497 GO:0090304 nucleic acid metabolic process
497 GO:0060255 regulation of macromolecule metabolic process
750 GO:0048468 cell development
750 GO:0060255 regulation of macromolecule metabolic process
750 GO:0007165 signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
284 GO:0005829 cytosol
284 GO:0005886 plasma membrane
497 GO:0005634 nucleus
750 GO:0005829 cytosol
750 GO:0043232 intracellular non-membrane-bounded organelle
750 GO:0005634 nucleus
750 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0006897 endocytosis IEA
GO:0006997 nucleus organization IMP
GO:0008283 cell proliferation TAS
GO:0016032 viral process IEA
GO:0030100 regulation of endocytosis IEA
GO:0042692 muscle cell differentiation IEA
GO:0043065 positive regulation of apoptotic process IDA
GO:0045664 regulation of neuron differentiation IMP
GO:0048711 positive regulation of astrocyte differentiation IMP
GO:0051647 nucleus localization IEA
GO:0060988 lipid tube assembly IMP
GO:0061024 membrane organization TAS
GO:0071156 regulation of cell cycle arrest IDA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0005635 nuclear envelope IEA
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0015629 actin cytoskeleton TAS
GO:0016020 membrane IDA
GO:0030018 Z disc ISS
GO:0030315 T-tubule ISS
GO:0030424 axon IDA
GO:0031674 I band ISS
GO:0033268 node of Ranvier ISS
GO:0043194 axon initial segment ISS
GO:0060987 lipid tube IMP
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
8782822 BIN1 is a novel Myc-interacting protein with features of a tumour suppressor.
9182667 Amphiphysin II (SH3P9; BIN1), a member of the amphiphysin/Rvs family, is concentrated in the cortical cytomatrix of axon initial segments and nodes of Ranvier in brain and around T tubules in skeletal muscle.
9195986 Identification and characterization of a nerve terminal-enriched amphiphysin isoform.
9223448 cDNA cloning of a novel amphiphysin isoform and tissue-specific expression of its multiple splice variants.
9395479 Structural analysis of the human BIN1 gene. Evidence for tissue-specific transcriptional regulation and alternate RNA splicing.
9418903 A role for the putative tumor suppressor Bin1 in muscle cell differentiation.
9603201 Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites.
10903846 Bin2, a functionally nonredundant member of the BAR adaptor gene family.
15815621 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
16530520 The SH3 binding motif of HCV NS5A protein interacts with Bin1 and is important for apoptosis and infectivity.
17081983 Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
17676042 Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy.
17974005 The full-ORF clone resource of the German cDNA consortium.
18669648 A quantitative atlas of mitotic phosphorylation.
19367720 Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20068231 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
OMIM ID Disease Name
255200 Myopathy, centronuclear, 2
Domain Name Domain ID Source
SH3_domain IPR001452 InterPro
Amphiphysin IPR003005 InterPro
Amphiphysin_2 IPR003023 InterPro
BAR_dom IPR004148 InterPro
AH/BAR_dom_sf IPR027267 InterPro
Amphiphysin-2_SH3 IPR035471 InterPro
SH3-like_dom_sf IPR036028 InterPro
JC5593 JC5593 PIR
BAR PF03114 Pfam
SH3_9 PF14604 Pfam
SSF103657 SSF103657 SUPFAM
SSF50044 SSF50044 SUPFAM
SH3_Bin1 cd12139 CDD