Protein: P0DP23

Uniprot: Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). more..
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0007165 signal transduction 4 GO:0006725 cellular aromatic compound metabolic process 53 5.44e-126 5.27e-27
Module ID (MoonGO) GO ID (BP) GO Name
4 GO:0035556 intracellular signal transduction
4 GO:0031399 regulation of protein modification process
4 GO:0009966 regulation of signal transduction
53 GO:0006139 nucleobase-containing compound metabolic process
53 GO:0016567 protein ubiquitination
53 GO:0060255 regulation of macromolecule metabolic process
172 GO:0060255 regulation of macromolecule metabolic process
359 GO:0044248 cellular catabolic process
359 GO:0000209 protein polyubiquitination
359 GO:0007165 signal transduction
381 GO:0006464 cellular protein modification process
381 GO:0010467 gene expression
381 GO:0016310 phosphorylation
381 GO:0010604 positive regulation of macromolecule metabolic process
381 GO:0050790 regulation of catalytic activity
381 GO:0032268 regulation of cellular protein metabolic process
381 GO:0007165 signal transduction
419 GO:0022607 cellular component assembly
774 GO:0006464 cellular protein modification process
774 GO:0060255 regulation of macromolecule metabolic process
775 GO:0044267 cellular protein metabolic process
775 GO:0010467 gene expression
775 GO:0006139 nucleobase-containing compound metabolic process
775 GO:0060255 regulation of macromolecule metabolic process
803 GO:0007166 cell surface receptor signaling pathway
803 GO:0044267 cellular protein metabolic process
803 GO:0071310 cellular response to organic substance
803 GO:0035556 intracellular signal transduction
803 GO:0009966 regulation of signal transduction
Module ID (MoonGO) GO ID (CC) GO Name
4 GO:0005829 cytosol
4 GO:0005634 nucleus
53 GO:0005829 cytosol
53 GO:0005654 nucleoplasm
359 GO:0005634 nucleus
381 GO:0005829 cytosol
381 GO:0005634 nucleus
419 GO:0044430 cytoskeletal part
419 GO:0005829 cytosol
774 GO:0005634 nucleus
775 GO:0005829 cytosol
775 GO:0005634 nucleus
803 GO:0016021 integral component of membrane
803 GO:0005886 plasma membrane
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000165 MAPK cascade TAS
GO:0002027 regulation of heart rate IMP
GO:0002576 platelet degranulation TAS
GO:0005513 detection of calcium ion IMP
GO:0005980 glycogen catabolic process TAS
GO:0006479 protein methylation TAS
GO:0006936 muscle contraction TAS
GO:0007223 Wnt signaling pathway, calcium modulating pathway TAS
GO:0010800 positive regulation of peptidyl-threonine phosphorylation TAS
GO:0010801 negative regulation of peptidyl-threonine phosphorylation TAS
GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IC
GO:0022400 regulation of rhodopsin mediated signaling pathway TAS
GO:0030801 positive regulation of cyclic nucleotide metabolic process IDA
GO:0030819 positive regulation of cAMP biosynthetic process IDA
GO:0031954 positive regulation of protein autophosphorylation TAS
GO:0032516 positive regulation of phosphoprotein phosphatase activity IDA
GO:0034220 ion transmembrane transport IEA
GO:0035307 positive regulation of protein dephosphorylation IDA
GO:0038095 Fc-epsilon receptor signaling pathway TAS
GO:0043647 inositol phosphate metabolic process TAS
GO:0050999 regulation of nitric-oxide synthase activity TAS
GO:0051343 positive regulation of cyclic-nucleotide phosphodiesterase activity IDA
GO:0051592 response to calcium ion IDA
GO:0055117 regulation of cardiac muscle contraction IMP
GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity IDA
GO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IDA
GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity IDA
GO:0071902 positive regulation of protein serine/threonine kinase activity TAS
GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction IC
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000922 spindle pole IEA
GO:0005576 extracellular region TAS
GO:0005654 nucleoplasm TAS
GO:0005737 cytoplasm IDA
GO:0005829 cytosol TAS
GO:0005886 plasma membrane TAS
GO:0014069 postsynaptic density IEA
GO:0030017 sarcomere IDA
GO:0034704 calcium channel complex IDA
GO:0043234 protein complex IDA
GO:1902494 catalytic complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0000922 spindle pole GO:0005886 plasma membrane 4.24e-02 6.65e-62
GO:0005576 extracellular region GO:0005654 nucleoplasm 6.62e-72 7.68e-98
GO:0005654 nucleoplasm GO:0005886 plasma membrane 9.14e-199 6.17e-196
GO:0005886 plasma membrane GO:1902494 catalytic complex 3.04e-46 1.13e-37
PMID Article Title
1474585 Calmodulin structure refined at 1.7 A resolution.
6385987 Isolation and nucleotide sequence of a cDNA encoding human calmodulin.
7093203 Complete amino acid sequence of human brain calmodulin.
7803388 Drug binding by calmodulin: crystal structure of a calmodulin-trifluoperazine complex.
7925473 Structure of the human CALM1 calmodulin gene and identification of two CALM1-related pseudogenes CALM1P1 and CALM1P2.
9804419 Structural basis for activation of the titin kinase domain during myofibrillogenesis.
9927666 Alpha-helix nucleation by a calcium-binding peptide loop.
11685248 Solution structure of Ca(2+)-calmodulin reveals flexible hand-like properties of its domains.
11807546 Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin.
12485993 Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins.
12508121 The DNA sequence and analysis of human chromosome 14.
12577052 Crystal structure of a MARCKS peptide containing the calmodulin-binding domain in complex with Ca2+-calmodulin.
12871148 Recombinant expression, purification and characterisation of the HMG domain of human SRY.
15489334 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15592455 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15719022 Calcium-independent calmodulin binding and two-metal-ion catalytic mechanism of anthrax edema factor.
15746192 Defective calmodulin-mediated nuclear transport of the sex-determining region of the Y chromosome (SRY) in XY sex reversal.
16127172 Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6.
16299511 Insights into voltage-gated calcium channel regulation from the structure of the CaV1.2 IQ domain-Ca2+/calmodulin complex.
16760425 CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability.
17719545 Cep97 and CP110 suppress a cilia assembly program.
18650434 S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
18669648 A quantitative atlas of mitotic phosphorylation.
19413330 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
19608861 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
19690332 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
20466722 Conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex.
21167176 Solution NMR structure of Apo-calmodulin in complex with the IQ motif of human cardiac sodium channel NaV1.5.
21269460 Initial characterization of the human central proteome.
21406692 System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
22223895 Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.
22484487 Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning.
22814378 N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
23040497 Mutations in calmodulin cause ventricular tachycardia and sudden cardiac death.
23109337 Crystal structure of calmodulin binding domain of orai1 in complex with Ca2+ calmodulin displays a unique binding mode.
23186163 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
23388215 Calmodulin mutations associated with recurrent cardiac arrest in infants.
23893133 Allosteric mechanism of water-channel gating by Ca(2+)-calmodulin.
24076290 A mutation in CALM1 encoding calmodulin in familial idiopathic ventricular fibrillation in childhood and adolescence.
24129315 Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
24275569 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
25944712 N-terminome analysis of the human mitochondrial proteome.
26164367 Distinctive malfunctions of calmodulin mutations associated with heart RyR2-mediated arrhythmic disease.
26969752 Spectrum and Prevalence of CALM1-, CALM2-, and CALM3-Encoded Calmodulin Variants in Long QT Syndrome and Functional Characterization of a Novel Long QT Syndrome-Associated Calmodulin Missense Variant, E141G.
27165696 Arrhythmogenic calmodulin mutations impede activation of small-conductance calcium-activated potassium current.
27516456 Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks.
27564677 Structural insights into the M-channel proximal C-terminus/calmodulin complex.
27876793 PEP-19 modulates calcium binding to calmodulin by electrostatic steering.
28112733 Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
OMIM ID Disease Name
614916 Ventricular tachycardia, catecholaminergic polymorphic, 4
616247 Long QT syndrome 14
Domain Name Domain ID Source
EF_hand_dom IPR002048 InterPro
EF-hand-dom_pair IPR011992 InterPro
EF_Hand_1_Ca_BS IPR018247 InterPro
EF-hand_7 PF13499 Pfam
SSF47473 SSF47473 SUPFAM
EFh cd00051 CDD