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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: Q12349
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
Q12349 (Uniprot)
ATP14_YEAST
ATP14
ATP synthase subunit H, mitochondrial
yeast
No
Protein Function
Uniprot:
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembrane
ous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.
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MoonDB Dissimilar Functions
Showing 1 to 10 of 10 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0006139
nucleobase-containing compound metabolic process
1059
GO:0006811
ion transport
1226
1.46e-19
8.47e-83
GO:0006725
cellular aromatic compound metabolic process
1176
GO:0006811
ion transport
1226
1.93e-19
6.20e-85
GO:0006811
ion transport
1226
GO:0034641
cellular nitrogen compound metabolic process
965
4.44e-27
1.76e-86
GO:0006811
ion transport
1226
GO:0009059
macromolecule biosynthetic process
1258
2.67e-40
7.66e-50
GO:0006811
ion transport
1226
GO:0044249
cellular biosynthetic process
1332
1.64e-27
1.21e-05
GO:0009059
macromolecule biosynthetic process
1258
GO:0015833
peptide transport
941
5.69e-13
2.89e-52
GO:0043170
macromolecule metabolic process
1073
,
1086
,
1132
,
1195
GO:0015833
peptide transport
941
3.85e-11
1.47e-03
GO:0043170
macromolecule metabolic process
1073
,
1086
,
1132
,
1195
GO:0006811
ion transport
1226
7.11e-80
2.62e-84
GO:0044260
cellular macromolecule metabolic process
989
GO:0015833
peptide transport
941
2.96e-17
2.61e-40
GO:0044260
cellular macromolecule metabolic process
989
GO:0006811
ion transport
1226
4.79e-76
5.35e-109
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 23 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
941
GO:0015031
protein transport
965
GO:0006139
nucleobase-containing compound metabolic process
989
GO:0016070
RNA metabolic process
989
GO:0010467
gene expression
1014
GO:0034622
cellular macromolecular complex assembly
1014
GO:0006139
nucleobase-containing compound metabolic process
1059
GO:0090304
nucleic acid metabolic process
1073
GO:0010467
gene expression
1086
GO:0010467
gene expression
1132
GO:0010467
gene expression
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Cellular Components
Showing 1 to 10 of 12 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
941
GO:0012505
endomembrane system
989
GO:0005634
nucleus
1014
GO:0005634
nucleus
1059
GO:0005634
nucleus
1086
GO:0005634
nucleus
1176
GO:0005634
nucleus
1195
GO:0044428
nuclear part
1307
GO:0012505
endomembrane system
1307
GO:0016021
integral component of membrane
1307
GO:0031984
organelle subcompartment
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Protein GO Annotations
Biological Processes
Showing 1 to 4 of 4 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0015986
ATP synthesis coupled proton transport
IPI
GO:0033615
mitochondrial proton-transporting ATP synthase complex assembly
IMP
GO:0042407
cristae formation
IMP
GO:0099132
ATP hydrolysis coupled cation transmembrane transport
IEA
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Cellular Components
Showing 1 to 1 of 1 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0000276
mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
IPI
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 123 entries
Search:
Interactor
Also a MoonDB EMF protein
ACF4_YEAST
No
AIM25_YEAST
No
AIM34_YEAST
No
ALF_YEAST
Yes:
P14540 (MoonDB)
ALG13_YEAST
No
AMPL_YEAST
No
AP1_YEAST
No
APA2_YEAST
No
ASP21_YEAST
No
ATP12_YEAST
No
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Publications Associated
Showing 1 to 5 of 5 entries
Search:
PMID
Article Title
8702761
ATP synthase of yeast mitochondria. Isolation of the subunit h and disruption of the ATP14 gene.
9169871
The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
14562106
Global analysis of protein expression in yeast.
17322287
Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24374639
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 4 of 4 entries
Search:
Domain Name
Domain ID
Source
ATP_sub_h
PF10775
Pfam
ATP_synth_F0_suH
IPR019711
InterPro
PTHR28207
PTHR28207
PANTHER
S50379
S50379
PIR
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