Protein: Q06406

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
Q06406 (Uniprot) LSM6_YEAST LSM6 U6 snRNA-associated Sm-like protein LSm6 yeast No
Uniprot: Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. In association with PAT1, LSM1-LSM7 binds directly to RNAs near the 3'-end and prefers oligoadenylated RNAs over polyadenylated RNAs. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA. Component of a nucleolar LSM2-LSM7 complex, which associates with the precursor of the RNA component of RNase P (pre-P RNA) and with the small nucleolar RNA (snoRNA) snR5. It may play a role in the maturation of a subset of nucleolus-associated small RNAs. more..
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:1901564 organonitrogen compound metabolic process 1307 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 1363 5.47e-08 1.83e-20
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
1099 GO:0016070 RNA metabolic process
1099 GO:0010467 gene expression
1180 GO:0016070 RNA metabolic process
1180 GO:0010467 gene expression
1180 GO:0060255 regulation of macromolecule metabolic process
1307 GO:1901566 organonitrogen compound biosynthetic process
1363 GO:0000398 mRNA splicing, via spliceosome
1363 GO:0006364 rRNA processing
1363 GO:0008033 tRNA processing
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
1099 GO:0030529 intracellular ribonucleoprotein complex
1180 GO:0005634 nucleus
1307 GO:0012505 endomembrane system
1307 GO:0016021 integral component of membrane
1307 GO:0031984 organelle subcompartment
1363 GO:1990726 Lsm1-7-Pat1 complex
1363 GO:0046540 U4/U6 x U5 tri-snRNP complex
1363 GO:0005688 U6 snRNP
1363 GO:0005730 nucleolus
1363 GO:0005732 small nucleolar ribonucleoprotein complex
1363 GO:0005681 spliceosomal complex
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000398 mRNA splicing, via spliceosome IPI
GO:0008033 tRNA processing IEA
GO:0030490 maturation of SSU-rRNA IMP
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IDA
GO:0005681 spliceosomal complex IEA
GO:0005688 U6 snRNP IDA
GO:0005730 nucleolus IDA
GO:0005732 small nucleolar ribonucleoprotein complex IPI
GO:0046540 U4/U6 x U5 tri-snRNP complex IDA
GO:1990726 Lsm1-7-Pat1 complex IDA
No pairs of PrOnto dissimilar CC GO terms found.
PMID Article Title
9169867 The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
10369684 Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.
10428970 Characterization of Sm-like proteins in yeast and their association with U6 snRNA.
10449419 Identification by mass spectrometry and functional analysis of novel proteins of the yeast [U4/U6.U5] tri-snRNP.
10747033 A Sm-like protein complex that participates in mRNA degradation.
10761922 Yeast Sm-like proteins function in mRNA decapping and decay.
15075370 An Lsm2-Lsm7 complex in Saccharomyces cerevisiae associates with the small nucleolar RNA snR5.
15485930 Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex.
15905473 Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.
17513695 The decapping activator Lsm1p-7p-Pat1p complex has the intrinsic ability to distinguish between oligoadenylated and polyadenylated RNAs.
18029398 Requirements for nuclear localization of the Lsm2-8p complex and competition between nuclear and cytoplasmic Lsm complexes.
24139796 Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.
24240276 Crystal structures of the Lsm complex bound to the 3' end sequence of U6 small nuclear RNA.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
24513854 Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex.
No results found.
Domain Name Domain ID Source
LSM_dom_euk/arc IPR001163 InterPro
LSM_dom_sf IPR010920 InterPro
Lsm6/sSmF IPR016487 InterPro
LSM PF01423 Pfam
PTHR11021 PTHR11021 PANTHER
S61173 S61173 PIR
Sm SM00651 SMART
SSF50182 SSF50182 SUPFAM