Protein: P47017

UniprotKB AC UniprotKB ID Gene name Full name Species Curated set
P47017 (Uniprot) LSM1_YEAST LSM1 Sm-like protein LSm1 yeast No
Uniprot: Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation by activating the decapping step. The LSM1-LSM7 complex binds RNA with a preference for poly-U ends.
MoonDB Dissimilar Functions
GO ID 1 Function 1 Module ID 1 GO ID 2 Function 2 Module ID 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0044260 cellular macromolecule metabolic process 894, 1041, 1099, 1152 GO:0070727 cellular macromolecule localization 1184 2.61e-07 8.40e-04
GO:0008104 protein localization 1184 GO:0044260 cellular macromolecule metabolic process 1188, 1250 7.50e-19 5.37e-13
Biological Processes
Module ID (MoonGO) GO ID (BP) GO Name
894 GO:0016070 RNA metabolic process
894 GO:0010467 gene expression
934 GO:0016310 phosphorylation
964 GO:0006397 mRNA processing
964 GO:0000956 nuclear-transcribed mRNA catabolic process
964 GO:0022613 ribonucleoprotein complex biogenesis
1041 GO:0016070 RNA metabolic process
1041 GO:0010467 gene expression
1099 GO:0016070 RNA metabolic process
1099 GO:0010467 gene expression
1152 GO:0016070 RNA metabolic process
1152 GO:0010467 gene expression
1184 GO:0034613 cellular protein localization
1188 GO:0016070 RNA metabolic process
1188 GO:0010467 gene expression
1250 GO:0016070 RNA metabolic process
1250 GO:0010629 negative regulation of gene expression
Cellular Components
Module ID (MoonGO) GO ID (CC) GO Name
894 GO:0044428 nuclear part
903 GO:0005634 nucleus
925 GO:0016021 integral component of membrane
964 GO:0000932 P-body
964 GO:0005634 nucleus
1041 GO:0005634 nucleus
1099 GO:0030529 intracellular ribonucleoprotein complex
1152 GO:0043232 intracellular non-membrane-bounded organelle
1152 GO:0031981 nuclear lumen
1184 GO:0005634 nucleus
1188 GO:0005634 nucleus
1250 GO:0043232 intracellular non-membrane-bounded organelle
1250 GO:0005634 nucleus
GO ID (BP) GO Name Evidence Code (GO EC)
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA IPI
GO:0006397 mRNA processing IEA
GO ID (CC) GO Name Evidence Code (GO EC)
GO:0000932 P-body IDA
GO:0005634 nucleus IDA
GO:0005737 cytoplasm IDA
GO:0005845 mRNA cap binding complex IPI
GO:1990726 Lsm1-7-Pat1 complex IDA
GO ID 1 Component 1 GO ID 2 Component 2 Association Probability (PrOnto) Interaction Probability (PrOnto)
GO:0005634 nucleus GO:0005737 cytoplasm 5.14e-51 7.30e-86
PMID Article Title
8641269 Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.
8948101 Sequencing analysis of a 40.2 kb fragment of yeast chromosome X reveals 19 open reading frames including URA2 (5' end), TRK1, PBS2, SPT10, GCD14, RPE1, PHO86, NCA3, ASF1, CCT7, GZF3, two tRNA genes, three remnant delta elements and a Ty4 transposon.
9710590 Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant.
10747033 A Sm-like protein complex that participates in mRNA degradation.
10761922 Yeast Sm-like proteins function in mRNA decapping and decay.
10913177 The two proteins Pat1p (Mrt1p) and Spb8p interact in vivo, are required for mRNA decay, and are functionally linked to Pab1p.
14562095 Global analysis of protein localization in budding yeast.
14562106 Global analysis of protein expression in yeast.
17322287 Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae.
24139796 Architecture of the Lsm1-7-Pat1 complex: a conserved assembly in eukaryotic mRNA turnover.
24374639 The reference genome sequence of Saccharomyces cerevisiae: Then and now.
24513854 Crystal structure and biochemical analysis of the heptameric Lsm1-7 complex.
No results found.
Domain Name Domain ID Source
LSM_dom_euk/arc IPR001163 InterPro
LSM_dom_sf IPR010920 InterPro
Lsm1 IPR034104 InterPro
LSM PF01423 Pfam
S56905 S56905 PIR
Sm SM00651 SMART
SSF50182 SSF50182 SUPFAM
LSm1 cd01728 CDD