Protein: P14540 | MoonDB v2.0

UniprotKB AC	UniprotKB ID	Gene name	Full name	Species	Curated set
P14540 (Uniprot)	ALF_YEAST	FBA1	Fructose-bisphosphate aldolase	yeast	Yes

Protein Function

Uniprot: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.

Dissimilar Functions Manual Curation

Function 1: Aldolase of the glycolysis pathway.

Function 2: Bind to vacuolar H+ATPase (V-ATPase).

Publications (PMID): 15877277

MoonDB Network Modules

Biological Processes

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Module ID (MoonGO)	GO ID (BP)	GO Name
941	GO:0015031	protein transport

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Cellular Components

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Module ID (MoonGO)	GO ID (CC)	GO Name
941	GO:0012505	endomembrane system

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Protein GO Annotations

Biological Processes

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GO ID (BP)	GO Name	Evidence Code (GO EC)
GO:0006094	gluconeogenesis	IMP
GO:0006096	glycolytic process	IMP

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Cellular Components

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GO ID (CC)	GO Name	Evidence Code (GO EC)
GO:0005739	mitochondrion	IDA
GO:0005829	cytosol	IDA
GO:0005886	plasma membrane	IBA
GO:0009277	fungal-type cell wall	IBA

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Dissimilar Cellular Components (PrOnto)

No pairs of PrOnto dissimilar CC GO terms found.

All Protein Interactions

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Interactor	Also a MoonDB EMF protein
ATP14_YEAST	Yes: Q12349 (MoonDB)

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Publications Associated

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PMID	Article Title
1698168	Cloning of Saccharomyces cerevisiae promoters using a probe vector based on phleomycin resistance.
2647491	Molecular cloning, primary structure and disruption of the structural gene of aldolase from Saccharomyces cerevisiae.
7895733	Protein identifications for a Saccharomyces cerevisiae protein database.
8091862	Sequence of a 28.6 kb region of yeast chromosome XI includes the FBA1 and TOA2 genes, an open reading frame (ORF) similar to a translationally controlled tumour protein, one ORF containing motifs also found in plant storage proteins and 13 ORFs with weak or no homology to known proteins.
8196765	Complete DNA sequence of yeast chromosome XI.
8935650	Protein expression during exponential growth in 0.7 M NaCl medium of Saccharomyces cerevisiae.
14562106	Global analysis of protein expression in yeast.
17287358	Analysis of phosphorylation sites on proteins from Saccharomyces cerevisiae by electron transfer dissociation (ETD) mass spectrometry.
17330950	Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
18407956	A multidimensional chromatography technology for in-depth phosphoproteome analysis.

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OMIM Diseases Associated

No results found.

Protein Domains Associated

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Domain Name	Domain ID	Source
ADBY2	S07855	PIR
ALDOLASE_CLASS_II_1	PS00602	PROSITE
ALDOLASE_CLASS_II_2	PS00806	PROSITE
Aldolase_TIM	IPR013785	InterPro
cbbA	TIGR00167	TIGRFAMs
F_bP_aldolase	PF01116	Pfam
F_bP_aldolase_II	PIRSF001359	PIRSF
FBA_II	IPR000771	InterPro
FBP_aldolase_IIA	cd00946	CDD
FruBisAldo_II_A	TIGR01520	TIGRFAMs

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