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A Database of Extreme Multifunctional and Moonlighting Proteins
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Protein: P36006
UniprotKB AC
UniprotKB ID
Gene name
Full name
Species
Curated set
P36006 (Uniprot)
MYO3_YEAST
MYO3
Myosin-3
yeast
No
Protein Function
Uniprot:
One of two redundant type-I myosins implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization and for the internalization step in endocytosis. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and
promotes actin assembly. Functions redundantly with LAS17 as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Motor domain phosphorylation by PAK kinases CLA4 and STE20 promotes CDC42-regulated actin assembly. Functions together with the NPF PAN1 in late stages of endocytosis. Motor domain phosphorylation by PDK1 kinases PKH1 and PKH2, and by SGK kinases YPK1 and YPK2, promotes ligand-induced, but not constitutive endocytosis of the G protein-coupled receptor STE2.
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MoonDB Dissimilar Functions
Showing 1 to 4 of 4 entries
Search:
GO ID 1
Function 1
Module ID 1
GO ID 2
Function 2
Module ID 2
Association Probability
(PrOnto)
Interaction Probability
(PrOnto)
GO:0043170
macromolecule metabolic process
992
GO:0097435
supramolecular fiber organization
1242
4.36e-08
1.57e-47
GO:0044260
cellular macromolecule metabolic process
1018
GO:0097435
supramolecular fiber organization
1242
6.22e-07
4.50e-41
GO:0097435
supramolecular fiber organization
1242
GO:0006725
cellular aromatic compound metabolic process
933
4.17e-09
4.54e-39
GO:0097435
supramolecular fiber organization
1242
GO:0034641
cellular nitrogen compound metabolic process
1332
5.28e-12
1.08e-45
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MoonDB Network Modules
Biological Processes
Showing 1 to 10 of 17 entries
Search:
Module ID
(MoonGO)
GO ID (BP)
GO Name
933
GO:0010467
gene expression
933
GO:0006139
nucleobase-containing compound metabolic process
934
GO:0016310
phosphorylation
992
GO:0010467
gene expression
1017
GO:0034314
Arp2/3 complex-mediated actin nucleation
1018
GO:0016070
RNA metabolic process
1018
GO:0010468
regulation of gene expression
1019
GO:0034314
Arp2/3 complex-mediated actin nucleation
1224
GO:0022607
cellular component assembly
1224
GO:0007010
cytoskeleton organization
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Cellular Components
Showing 1 to 10 of 11 entries
Search:
Module ID
(MoonGO)
GO ID (CC)
GO Name
884
GO:0043232
intracellular non-membrane-bounded organelle
933
GO:0005634
nucleus
948
GO:0043232
intracellular non-membrane-bounded organelle
954
GO:0043232
intracellular non-membrane-bounded organelle
992
GO:0005634
nucleus
1017
GO:0030479
actin cortical patch
1018
GO:0043232
intracellular non-membrane-bounded organelle
1018
GO:0005634
nucleus
1019
GO:0030479
actin cortical patch
1224
GO:0043232
intracellular non-membrane-bounded organelle
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Protein GO Annotations
Biological Processes
Showing 1 to 7 of 7 entries
Search:
GO ID (BP)
GO Name
Evidence Code
(GO EC)
GO:0006887
exocytosis
TAS
GO:0006897
endocytosis
TAS
GO:0006970
response to osmotic stress
TAS
GO:0007121
bipolar cellular bud site selection
TAS
GO:0031505
fungal-type cell wall organization
TAS
GO:0051666
actin cortical patch localization
IGI
GO:2000601
positive regulation of Arp2/3 complex-mediated actin nucleation
IDA
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Cellular Components
Showing 1 to 2 of 2 entries
Search:
GO ID (CC)
GO Name
Evidence Code
(GO EC)
GO:0016459
myosin complex
IEA
GO:0030479
actin cortical patch
TAS
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Dissimilar Cellular Components (PrOnto)
No pairs of PrOnto dissimilar CC GO terms found.
All Protein Interactions
Showing 1 to 10 of 44 entries
Search:
Interactor
Also a MoonDB EMF protein
2ABA_YEAST
No
AIM21_YEAST
No
APP1_YEAST
No
ARPC1_YEAST
No
ARPC4_YEAST
No
BBC1_YEAST
Yes:
P47068 (MoonDB)
BCK1_YEAST
No
BNI1_YEAST
No
BNR1_YEAST
No
BZZ1_YEAST
Yes:
P38822 (MoonDB)
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Publications Associated
Showing 1 to 10 of 17 entries
Search:
PMID
Article Title
7728870
Identification and molecular characterization of a yeast myosin I.
8196765
Complete DNA sequence of yeast chromosome XI.
8614799
Role of type I myosins in receptor-mediated endocytosis in yeast.
8682864
Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton.
9388196
The phosphorylation site for Ste20p-like protein kinases is essential for the function of myosin-I in yeast.
10648568
A role for myosin-I in actin assembly through interactions with Vrp1p, Bee1p, and the Arp2/3 complex.
10648569
Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
11901111
The novel adaptor protein, Mti1p, and Vrp1p, a homolog of Wiskott-Aldrich syndrome protein-interacting protein (WIP), may antagonistically regulate type I myosins in Saccharomyces cerevisiae.
12725728
The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function.
12808026
She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae.
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OMIM Diseases Associated
No results found.
Protein Domains Associated
Showing 1 to 10 of 21 entries
Search:
Domain Name
Domain ID
Source
Fungal_myosin-I_SH3
IPR035535
InterPro
Myosin_head
PF00063
Pfam
Myosin_head_motor_dom
IPR001609
InterPro
MYOSIN_MOTOR
PS51456
PROSITE
Myosin_TH1
IPR010926
InterPro
Myosin_TH1
PF06017
Pfam
MYOSINHEAVY
PR00193
PRINTS
MYSc
SM00242
SMART
MYSc_Myo1
IPR036072
InterPro
MYSc_Myo1
cd01378
CDD
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